Magnetic Nanoparticle Coating Decreases the Senescence and Increases the Targeting Potential of Fibroblasts and Adipose-Derived Mesenchymal Stem Cells.

Magnetic nanoparticles (MNPs) are intensely scrutinized for applications in emerging biomedical fields. Their potential use for drug delivery, tracking, and targeting agents or for cell handling is tested for regenerative medicine and tissue engineering applications. The large majority of MNPs tested for biomedical use are coated with different lipids and natural or synthetic polymers in order to decrease their degradation process and to increase the ability to transport drugs or bioactive molecules.

Cellulose acetate/silica composites: Physicochemical and biological characterization.

Cellulose acetate is of remarkable scientific interest, becoming more useful when is used in obtaining of the composite materials containing nanoparticles, as result of its improved properties. Thus, cellulose acetate/silica composite films obtained by casting the solutions of cellulose acetate (CA)/tetraethyl orthosilicate (TEOS) in different mixing ratios were analyzed in this paper. The impact of TEOS addition, and implicitly of the silica nanoparticles on the mechanical strength, water vapor sorption properties and antimicrobial activity of the cellulose acetate/silica films were mainly monitored.

Emotional relevance and prejudice: testing the differentiated effect of incidental disgust on prejudice towards ethnic minorities.

Negative emotions such as disgust or anger influence the evaluation of minorities and amplify prejudice, stereotypes, and discrimination behaviors towards them. However, new discoveries suggest that these spillover effects might be more specific in the sense that the bias might occur only if the emotions are specific to the affect that is generally evoked by that particular minority, i.e.

Phenothiazine- and Carbazole-Cyanochalcones as Dual Inhibitors of Tubulin Polymerization and Human Farnesyltransferase.

In the search for innovative approaches to cancer chemotherapy, a chemical library of 49 cyanochalcones, , , and , was designed as dual inhibitors of human farnesyltransferase (FTIs) and tubulin polymerization (MTIs) (FTIs/MTIs), two important biological targets in oncology. This approach is innovative since the same molecule would be able to interfere with two different mitotic events of the cancer cells and prevent these cells from developing an emergency route and becoming resistant to anticancer agents. Compounds were synthesized by the Claisen-Schmidt condensation of aldehydes with -3-oxo-propanenitriles under classical magnetic stirring and under sonication.

Hyperhalophilic Diatom Extract Protects against Lead-Induced Oxidative Stress in Rats and Human HepG2 and HEK293 Cells.

This work investigated the protective effects of microalga sp. extract (HExt), a nutraceutical and pharmacological natural product, on human lead-intoxicated liver and kidney cells in vitro and in vivo in Wistar rats. The human hepatocellular carcinoma cell line HepG2 and the human embryonic kidney cell line HEK293 were used for the in vitro study.

Exploring Pyrrolo-Fused Heterocycles as Promising Anticancer Agents: An Integrated Synthetic, Biological, and Computational Approach.

Five new series of pyrrolo-fused heterocycles were designed through a scaffold hybridization strategy as analogs of the well-known microtubule inhibitor phenstatin. Compounds were synthesized using the 1,3-dipolar cycloaddition of cycloimmonium N-ylides to ethyl propiolate as a key step. Selected compounds were then evaluated for anticancer activity and ability to inhibit tubulin polymerization in vitro.

Omics-Based Investigations of Breast Cancer.

Breast cancer (BC) is characterized by an extensive genotypic and phenotypic heterogeneity. In-depth investigations into the molecular bases of BC phenotypes, carcinogenesis, progression, and metastasis are necessary for accurate diagnoses, prognoses, and therapy assessments in predictive, precision, and personalized oncology. This review discusses both classic as well as several novel omics fields that are involved or should be used in modern BC investigations, which may be integrated as a holistic term, onco-breastomics.

Foreign Body Aspiration in Children-Retrospective Study and Management Novelties.

Foreign body aspiration (FBA) is a frequent diagnosis in children. In the absence of other lung conditions, such as asthma or chronic pulmonary infections, this manifests as a sudden onset of cough, dyspnea, and wheezing. The differential diagnosis is based on a scoring system which takes into account the clinical picture as well as the radiologic aspects.

Comparative Study of Flesh Quality, Blood Profile, Antioxidant Status, and Intestinal Microbiota of European Catfish () Cultivated in a Recirculating Aquaculture System (RAS) and Earthen Pond System.

With the increasing demand for European catfish, traditional extensive growth methods in polyculture are no longer sufficient to meet market needs. Therefore, this study aimed to identify indicators for improving recirculating aquaculture system (RAS) technology by determining and comparing growth performance, flesh quality, blood profile, oxidative status, and intestinal microbiota parameters between fish cultivated in a RAS and an earthen pond. Results revealed that RAS-grown fish had a higher fat content compared to pond-grown fish, while no significant differences were found for growth parameters.

Introducing Computerized Technology to Nurses: A Model Based on Cognitive Instrumental and Social Influence Processes.

The use of computerized technologies as an integral part of nursing has become a reality in the health care system. Studies present different approaches that range from accepting technology as a health promoter to an approach that opposes computerization. This study, which examined social and instrumental processes that influence nurses' attitudes toward computer technology, will present a model for the optimal assimilation of computer technology in the nurses' work environment.

A Review of the Most Recent Clinical and Neuropathological Criteria for Chronic Traumatic Encephalopathy.

(1) Background: Chronic traumatic encephalopathy (CTE) is a complex pathological condition characterized by neurodegeneration, as a result of repeated head traumas. Currently, the diagnosis of CTE can only be assumed postmortem. Thus, the clinical manifestations associated with CTE are referred to as traumatic encephalopathy syndrome (TES), for which diagnostic multiple sets of criteria can be used.

Sense of Relational Entitlement and Couple Outcomes: The Mediating Role of Couple Negotiation Tactics.

Previous research shows a link between the sense of relational entitlement and various couple outcomes. However, the mechanisms linking these variables are less discussed. With this study, the aim was to test the associations between individuals' excessive and restricted sense of relational entitlement and their levels of couple satisfaction and conflict.

Exploring the Impact of Time Spent Reading Product Information on E-Commerce Websites: A Machine Learning Approach to Analyze Consumer Behavior.

In this study, we aim to investigate the influence of the time spent reading product information on consumer behavior in e-commerce. Given the rapid growth of e-commerce and the increasing importance of understanding online consumer behavior, our research focuses on gaining a deeper understanding of customer navigation on e-commerce websites and its effects on purchasing decisions. Recognizing the multidimensional and dynamic nature of consumer behavior, we utilize machine learning techniques, which offer the capacity to handle complex data structures and reveal hidden patterns within the data, thereby augmenting our comprehension of underlying consumer behavior mechanisms.

How good do you think you are with computers? The link between teachers' perceived digital literacy, occupational efficacy, and psychological distress.

The present study focused on teachers' perceived digital literacy, occupational self-efficacy, and psychological distress. Our sample included 279 Romanian teachers aged 20 to 66 ( = 31.92,  = 11.

Eco-friendly cellulose-based hydrogel functionalized by NIR-responsive multimodal antibacterial polymeric ionic liquid as platform for promoting wound healing.

With the trend of sustainable development and the complex medical environment, there is a strong demand for multimodal antibacterial cellulose wound dressing (MACD) with photothermal therapy (PTT). Herein, a novel MACD fabrication strategy with PTT was proposed and implemented through graft polymerization of an imidazolium ionic liquid monomer containing iron complex anion structure. The fabricated hydrogels exhibited excellent antibacterial properties because of the efficient photothermal conversion ability (68.

Synthesis, Development and Characterization of Nanotubes.

In recent decades, the great demand for device miniaturization has attracted the attention of researchers focused on the growth, modification, properties, and applications of one-dimensional nanostructures, such as nanotubes [...

Adhesion Properties and Stability of Non-Polar Polymers Treated by Air Atmospheric-Pressure Plasma.

Atmospheric-pressure plasma (APP) has advantages for enhancing the adhesion of polymers and has to provide uniform, efficient treatment, which also limits the recovery effect of treated surfaces. This study investigates the effects of APP treatment on polymers that have no oxygen bonded in their structure and varying crystallinity, aiming to assess the maximum level of modification and the post-treatment stability of non-polar polymers based on their initial structure parameters, including the crystalline-amorphous structure. An APP reactor simulating continuous processing operating in air is employed, and the polymers are analyzed using contact angle measurement, XPS, AFM, and XRD.

The Implications of SARS-CoV-2 Infection in a Series of Neuro-Ophthalmological Manifestations-Case Series and Literature Review.

The global pandemic impact of the COVID-19 infection included clinical manifestations that affected several organs and systems, with various neuro-ophthalmological manifestations associated with the infection. These are rare and occur either secondary to the presence of the virus or by an autoimmune mechanism secondary to viral antigens. The manifestations are atypical, being present even in the absence of the systemic symptoms typical of a SARS-CoV-2 infection.

[2.2]Paracyclophane Derivatives as Building Blocks for Coordination Polymers.

Several new di- and tetracarboxylic [2.2]paracyclophane derivatives were obtained via Suzuki coupling between the appropriately brominated [2.2]paracyclophanes and 4-(methoxycarbonyl)phenylboronic acid.

COVID-19 vaccination and governance in the case of low, middle and high-income countries.

Background: Global crises, regardless of the place where they started to spread or of the factors that triggered them, require a comprehensive approach, primarily based on good communication, cooperation and mutual support. No individual and no institution should remain indifferent to crises but, on the contrary, be fully aware that any involvement in curbing them matters. Although humanity can be affected by various types of crises, in this paper we refer to the one related to COVID-19 pandemic.

Health anxiety, death anxiety and coronaphobia: Predictors of postpartum depression symptomatology during the COVID-19 pandemic.

Objective: To determine levels of postpartum depression symptoms and possible relevant predictors, such as death anxiety, health anxiety, and coronavirus-related anxiety.

Design: Cross-sectional web-based survey using quantitative methods.

Setting: Exclusively online recruiting via social media and unpaid cross-posting conducted during the third wave of the COVID-19 pandemic in Romania.

Frequent attenders in primary health care: a mixed-methods study of patient and staff perspectives.

Aims And Objective: To understand the frequent attendance phenomenon from the perspective of patients and healthcare professionals and how it can be reduced.

Background: Frequent attenders (FAs) are characterised by the consumption of a disproportionate number of medical consultations and a high number of visits per year to primary care physicians (PCP). Although FAs constitute about 10% of all primary clinic attendees, they are responsible for ~40-50% of clinic visits, affecting the efficiency, accessibility and quality of health services provided to other patients.

Exploring the links between flood events and the COVID-19 infection cases in Romania in the new multi-hazard-prone era.

The occurrence of flood events amid the COVID-19 pandemic represents a prominent part of the emerging multi-hazard landscape, as floods are one of the most frequent and destructive natural hazards. This spatial and temporal overlap of hydrological and epidemiological hazards translates into compounded negative effects, causing a shift in the hazard management paradigm, in which hazard interaction takes centre stage. This paper calls into question whether the river flood events that occurred during the COVID-19 pandemic in Romania and the way that they were managed had an impact on the infection with the SARS-CoV-2 virus at county scale.

Children's peer relationships, well-being, and academic achievement: the mediating role of academic competence.

The present study aimed to explore the interplay among two indicators of children's school peer relationships (i.e., peer acceptance and perceived number of friends) and two significant life domains (i.