181 results match your criteria: "'A. Sygros' Hospital for Cutaneous & Venereal Diseases[Affiliation]"

Dermoscopy of Primary Cutaneous B-Cell Lymphoma: A Systematic Review.

Australas J Dermatol

January 2025

1st Department of Dermatology, "Andreas Sygros" Hospital for Skin Diseases, National and Kapodistrian University of Athens, Medical School, Athens, Greece.

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A unique collaboration of multi-disciplinary experts from the European Association of Dermato-Oncology (EADO), the European Dermatology Forum (EDF), and the European Organization of Research and Treatment of Cancer (EORTC) was formed to make recommendations on cutaneous melanoma diagnosis and treatment, based on systematic literature reviews and the experts' experience. Cutaneous melanomas are excised with one to two-centimeter safety margins. For a correct stage classification and treatment decision, a sentinel lymph node biopsy shall be offered in patients with tumor thickness ≥ 1.

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This guideline was developed in close collaboration with multidisciplinary experts from the European Association of Dermato-Oncology (EADO), the European Dermatology Forum (EDF) and the European Organization for Research and Treatment of Cancer (EORTC). Recommendations for the diagnosis and treatment of melanoma were developed on the basis of systematic literature research and consensus conferences. Cutaneous melanoma (CM) is the most dangerous form of skin tumor and accounts for 90 % of skin cancer mortality.

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European S2k guidelines for hidradenitis suppurativa/acne inversa part 2: Treatment.

J Eur Acad Dermatol Venereol

December 2024

European Hidradenitis Suppurativa Foundation e.V., Dessau, Germany.

Introduction: This second part of the S2k guidelines is an update of the 2015 S1 European guidelines.

Objective: These guidelines aim to provide an accepted decision aid for the selection, implementation and assessment of appropriate and sufficient therapy for patients with hidradenitis suppurativa/acne inversa (HS).

Methods: The chapters have been selected after a Delphi procedure among the experts/authors.

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Clinical features, treatment options and outcomes in primary cutaneous B-cell lymphomas: a real-world, multicenter, retrospective study.

Int J Dermatol

November 2024

Department of Hematology and Bone Marrow Transplantation, Laikon General Hospital, National & Kapodistrian University of Athens, Medical School, Athens, Greece.

Background: Primary cutaneous B-cell lymphomas (PCBCLs) are rare cutaneous neoplasms with limited literature regarding treatment options and associated treatment outcomes. This study aimed to investigate and present real-world treatment outcomes in patients with PCBCLs.

Methods: All patients with PCBCL who were treated in five major referral centers for cutaneous lymphoma in Greece over 10 years were retrospectively included with their baseline characteristics and treatment-associated outcomes collected and analyzed.

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Article Synopsis
  • - The phase 2 EMPOWER-CSCC-1 study showed that cemiplimab is effective against advanced cutaneous squamous cell carcinoma (CSCC), specifically in metastatic and locally advanced cases.
  • - The study involved different treatment groups receiving either weight-based or fixed-dose cemiplimab, with a significant overall response rate (ORR) of 47.2% after 42.5 months and noted long-duration responses.
  • - While the findings are promising, the study's limitations include its nonrandomized design and the fact that the primary endpoint was not based on survival rates.
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Article Synopsis
  • The study focuses on a coagulase-negative staphylococcus (CoNS) known for its ability to cause severe skin infections, as assessed in patients at a hospital in Greece over a decade.
  • A total of 123 skin specimens reflecting the diversity of infections were analyzed, with hidradenitis suppurativa being the most frequent condition, and many cases also presenting co-infections.
  • The majority of patients received effective systemic antibiotic treatments, leading to a 100% cure rate, though some notable antibiotic resistance was found against penicillin and clindamycin.
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Article Synopsis
  • A phase 2 study of cemiplimab showed a 24.1% objective response rate in patients with metastatic basal cell carcinoma who couldn't continue hedgehog inhibitor therapy due to side effects, disease progression, or stable disease after nine months.
  • Patients were given intravenous cemiplimab and their health-related quality of life was assessed using questionnaires at various treatment cycles.
  • Results indicated most patients experienced low symptom burden and moderate-to-high functioning, with significant improvements or maintenance in quality of life and functioning scales reported throughout treatment cycles.
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Background: There is currently no staging system for cutaneous squamous cell carcinoma (cSCC) that is adapted to decision-making and universally used. Experts have unconscious ability to simplify the heterogeneity of clinical situations into a few relevant groups to drive their therapeutic decisions. Therefore, we have used unsupervised clustering of real cases by experts to generate an operational classification of cSCCs, an approach that was successful for basal cell carcinomas.

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Background: Merkel cell carcinoma (MCC) is a rare, aggressive, cutaneous tumour with high mortality and frequently delayed diagnosis. Clinically, it often manifests as a rapidly growing erythematous to purple nodule usually located on the lower extremities or face and scalp of elderly patients. There is limited available data on the dermoscopic findings of MCC, and there are no specific features that can be used to definitively diagnose MCC.

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Article Synopsis
  • Skin cancers are super common, especially in people with fair skin, and most of them are caused by UV rays from the sun, which means we can do things to prevent them.
  • Experts from different continents suggest that fair-skinned people, especially kids, should stay out of the sun when the UV level is 3 or higher and use protection like hats, sunglasses, clothing, and sunscreen.
  • They also believe sunbathing and using tanning beds are unhealthy, so they want to spread these ideas to help everyone stay safe from skin cancer.
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Article Synopsis
  • Inconsistent reporting of outcomes in rosacea clinical trials is hindering accurate data analysis and meta-analyses, highlighting the need for standardized outcome measures.
  • A core outcome set (COS) was developed through systematic literature reviews and a Delphi process, involving feedback from physicians and patients to identify essential outcomes in rosacea trials.
  • The final COS includes 8 key domains, such as skin symptoms and patient satisfaction, which aim to enhance the comparability and relevance of future rosacea research and interventions.
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Diagnosis of invasive cutaneous squamous cell carcinoma, imaging and staging.

Ital J Dermatol Venerol

April 2024

First Department of Dermatology-Venereology, National and Kapodistrian University of Athens, Andreas Sygros Hospital, Athens, Greece -

Article Synopsis
  • Assessment of suspected invasive cutaneous squamous cell carcinoma (cSCC) involves a multistep approach to ensure accurate diagnosis and treatment planning.
  • The primary diagnostic goals include distinguishing cSCC from other conditions and assessing the extent of tumor spread, which can range from common cSCC to advanced or metastatic cases.
  • Diagnostic methods include clinical evaluation, dermoscopy, histopathology, and imaging techniques like ultrasound or CT/MRI to evaluate regional lymph nodes and deeper tissue involvement.*
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Article Synopsis
  • The study focused on the characteristics and dermatoscopic features of cutaneous metastases (CMs) from various primary tumors, highlighting the challenge of diagnosing them.
  • A total of 583 patients were analyzed, with melanomas being the most common primary tumors, and a significant portion of the metastases was found in the head and neck region.
  • The findings suggest that pigmented melanoma metastases often appear as structureless blue lesions, while amelanotic metastases display linear serpentine vessels; both types can be confused with other skin lesions.
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Article Synopsis
  • Primary cutaneous lymphomas (PCLs) are a diverse group of skin-related non-Hodgkin lymphomas, primarily affecting T- or B-lymphocytes, and there's a lack of extensive data on their occurrence.
  • A study in Attica, Greece, analyzed 1,189 patients diagnosed with PCL from 2009 to 2021, revealing a median diagnosis age of 62, with a higher prevalence in males, and an annual incidence rate (IR) of 2.2 per 100,000 individuals.
  • The majority of cases were cutaneous T-cell lymphoma (CTCL) and specifically mycosis fungoides (MF), while the incidence rates increased until 2019 but
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A collaboration of multidisciplinary experts from the European Association of Dermato-Oncology, the European Dermatology Forum, the European Academy of Dermatology and Venereology, and the European Union of Medical Specialists was formed to develop European recommendations on AK diagnosis and treatment, based on current literature and expert consensus. This guideline addresses the epidemiology, diagnostics, risk stratification and treatments in immunocompetent as well as immunosuppressed patients. Actinic keratoses (AK) are potential precursors of cutaneous squamous cell carcinoma (cSCC) and display typical histopathologic and immunohistochemical features of this malignancy in an early stage.

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Use of Dermoscopy among Greek Dermatologists in Everyday Clinical Practice: A National Questionnaire-Based Study.

J Clin Med

February 2024

2nd Department of Dermatology and Venereology, "Attikon" General University Hospital, Medical School, National and Kapodistrian University of Athens, 12462 Athens, Greece.

: Dermatoscopy has been established as an important diagnostic tool for a wide range of skin diseases. This study aims to evaluate the use of dermatoscopy in clinical practice among Greek dermatologists. : A nationwide questionnaire-based survey was conducted collecting data on the frequency of dermatoscopic examinations, the types of lesions examined, training and educational resources, as well as factors influencing the choice to incorporate dermatoscopy into daily clinical routines.

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A Retrospective Study of Diameter and Breslow Thickness in Invasive Melanomas.

Dermatology

June 2024

Skin Cancer and Melanoma Unit, 1st Department of Dermatology, A.Sygros Hospital, University of Athens, Athens, Greece.

Article Synopsis
  • - The study explored the relationship between Breslow thickness (a measure of melanoma depth) and the diameter of cutaneous melanoma, focusing on patients with nodular melanoma (NM) and superficial spreading melanoma (SSM).
  • - Out of 537 melanoma cases analyzed, NM had a greater Breslow thickness compared to SSM, but there was no significant correlation between thickness and melanoma diameter, even after adjusting for factors like age and sex.
  • - The findings suggest that relying on a diameter greater than 6 mm may not be effective for detecting invasive melanomas, highlighting that smaller melanomas can also be significantly thicker.
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HIV and mpox: Evaluation of clinical course and outcomes from an international dermatologic registry.

J Am Acad Dermatol

May 2024

Department of Dermatology, Massachusetts General Hospital, Boston, Massachusetts; International Foundation for Dermatology, London, United Kingdom; Medical Practice Evaluation Foundation, Massachusetts General Hospital, Boston, Massachusetts. Electronic address:

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Article Synopsis
  • Metastatic basal cell carcinoma (mBCC) is challenging to treat, and cemiplimab, an immune checkpoint inhibitor, has been evaluated after previous hedgehog pathway inhibitor (HHI) treatment.
  • In a phase II study with 54 patients, cemiplimab showed a 22% objective response rate, including complete and partial responses, and a disease control rate of 63%.
  • The treatment was relatively well-tolerated with common side effects like fatigue and diarrhea, and the median overall survival was 50 months without treatment-related deaths.
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Resorcinol 10% as a Promising Therapeutic Option for Mild Hidradenitis Suppurativa: A Prospective, Randomized, Open Study.

Skin Appendage Disord

December 2023

2nd Department of Dermatology and Venereology, National and Kapodistrian University of Athens, Medical School, "Attikon" General University Hospital, Athens, Greece.

Introduction: Treatment of hidradenitis suppurativa (HS) is challenging, and in Hurley stage I, it is based on topical measures. Our aim was to compare the efficacy and safety of topical resorcinol 10% with topical clindamycin 1% and no therapy, in Hurley stage I HS.

Methods: In this open, prospective, randomized trial, we studied 60 Hurley stage I patients with IHS4 ≤10.

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Seven Plus One Steps to Assess Pigmented Nail Bands (Melanonychia Striata Longitudinalis).

Dermatol Pract Concept

October 2023

Service de Dermatologie, Centre Hospitalier Lyon Sud, Hospices Civils de Lyon, Lyon, France; Université Claude-Bernard-Lyon Lyon, Lyon, France and Lyons cancer research center UMR INSERM U1052 - CNRS5286 - UCBL1 Lyon France.

Article Synopsis
  • Melanonychia striata longitudinalis affects fingers and toes with causes ranging from benign conditions to malignant tumors, making diagnosis complex.
  • Nail matrix melanoma is rare, typically affecting adults and primarily occurs in the first toe or thumb, while squamous cell carcinoma of the nail matrix often lacks pigmentation.
  • A systematic diagnostic approach, involving factors like age, number of nails involved, and color, is recommended to accurately assess and differentiate the specific causes of this condition.
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