18,130 results match your criteria: ""la Sapienza" University[Affiliation]"

Objectives: This study aims to evaluate the technical and clinical outcomes of the E-nside stent graft for thoraco-abdominal aortic aneurysm (TAAA) and pararenal abdominal aortic aneurysm (PAAA) endovascular treatment at our University Hospital Center.

Methods: We conducted a retrospective analysis of patients electively treated by inner branched EVAR (iBEVAR) between 05/2021 and 03/2023. Demographic, procedural, and clinical data were analyzed.

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The present study is the first meta-analysis comparing long-term outcomes in patients undergoing correction for anomalous left coronary artery (ALCAPA) regarding concomitant mitral valve surgery. A systematic literature review was conducted to identify all relevant studies with comparative data on mitral valve surgery performed during surgery for ALCAPA correction. Predefined primary end points included mortality and mitral valve (re)operation.

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Background: Malaria remains a significant public health challenge in Cameroon, particularly affecting children under 5 years of age. Despite these efforts, its prevalence persists, highlighting the need for comprehensive epidemiological studies to guide interventions.

Methods: A cross-sectional study was conducted in five randomly selected health areas across five regions of Cameroon.

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Electrical polarization switching of perovskite polariton laser.

Nanophotonics

June 2024

Faculty of Physics, Institute of Experimental Physics, University of Warsaw, ul. Pasteura 5, PL-02-093 Warsaw, Poland.

Optoelectronic and spinoptronic technologies benefit from flexible and tunable coherent light sources combining the best properties of nano- and material-engineering to achieve favorable properties such as chiral lasing and low threshold nonlinearities. In this work we demonstrate an electrically wavelength- and polarization-tunable room temperature polariton laser due to emerging photonic spin-orbit coupling. For this purpose, we design an optical cavity filled with both birefringent nematic liquid crystal and an inorganic perovskite.

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The Indo-European languages are among the most widely spoken in the world, yet their early diversification remains contentious. It is widely accepted that the spread of this language family across Europe from the 5th millennium BP correlates with the expansion and diversification of steppe-related genetic ancestry from the onset of the Bronze Age. However, multiple steppe-derived populations co-existed in Europe during this period, and it remains unclear how these populations diverged and which provided the demographic channels for the ancestral forms of the Italic, Celtic, Greek, and Armenian languages.

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Background: Hepatocellular carcinoma (HCC) exhibits an exceptional intratumoral heterogeneity that might influence diagnosis and outcome. Advances in digital microscopy and artificial intelligence (AI) may improve the HCC identification of liver cancer cells.

Aim: Two AI algorithms were designed to perform computer-assisted discrimination of tumour from non-tumour nuclei in HCC.

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Allograft versus autograft ACL reconstruction in skeletally immature patients: a systematic review.

Br Med Bull

December 2024

Department of Trauma and Orthopaedic Surgery, Faculty of Medicine and Psychology, University La Sapienza, Via di Grattarossa, 00189 Rome, Italy.

Introduction: Anterior cruciate ligament (ACL) injuries in children and adolescents with open physes are common.

Areas Of Agreement: Evidence of ACL reconstruction using allografts in children with open physes is limited.

Areas Of Controversy: Whether the outcomes of ACL allograft reconstruction in children and adolescents with open physes are superior to autograft ACL reconstruction is unclear, with contrasting evidence.

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Purpose: The present prospective comparative study included patients with acute Achilles tendon rupture (ATR) who underwent percutaneous repair with one knot compared to percutaneous repair with two knots.

Methods: All patients underwent the procedure under local anesthesia. A total of 29 patients underwent percutaneous repair with two knots (Group A), and 33 patients underwent percutaneous repair with one knot (Group B).

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Intrinsic and environmental drivers of pairwise cohesion in wild Canis social groups.

Ecology

December 2024

Wildlife Research and Monitoring Section, Ministry of Natural Resources and Forestry, Peterborough, Ontario, Canada.

Animals within social groups respond to costs and benefits of sociality by adjusting the proportion of time they spend in close proximity to other individuals in the group (cohesion). Variation in cohesion between individuals, in turn, shapes important group-level processes such as subgroup formation and fission-fusion dynamics. Although critical to animal sociality, a comprehensive understanding of the factors influencing cohesion remains a gap in our knowledge of cooperative behavior in animals.

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Pulmonary hypertension (PH) is a frequent complication of chronic lung disease (CLD). However, PH is difficult to diagnose early since accompanying symptoms overlap and are similar to those of the underlying CLD. In most cases the PH is mild to moderate and therefore physical signs may be absent or subtle.

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Structure-based drug design with equivariant diffusion models.

Nat Comput Sci

December 2024

École Polytechnique Fédérale de Lausanne, Lausanne, Switzerland.

Article Synopsis
  • - Structure-based drug design (SBDD) focuses on creating small molecules that accurately target specific proteins, using structural data to help propose new drug candidates.
  • - Current methods typically require extensive dataset preparation and retraining for different tasks, while our approach introduces a single pretrained model that can handle multiple design challenges.
  • - We introduce DiffSBDD, a diffusion model that generates new ligands based on protein structures, and demonstrate how it can be enhanced with constraints for better drug candidate quality.
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How to define temperature in active systems?

J Chem Phys

December 2024

Institute of Condensed Matter Physics, Department of Physics, Technical University of Darmstadt, Hochschulstraße 8, D-64289 Darmstadt, Germany.

We are used to measuring temperature with a thermometer, and we know from everyday life that different types of thermometers measure the same temperature. This experience can be based on equilibrium thermodynamics, which explains the equivalence of different possibilities to define temperature. In contrast, for systems out of equilibrium such as active matter, measurements performed with different thermometers can generally lead to different temperature values.

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Background: Sex may impact clinical outcomes in patients with stroke treated with dual antiplatelet therapy (DAPT). We aimed to investigate the sex differences in the short-term outcomes of DAPT within a real-world population of patients with noncardioembolic mild-to-moderate ischemic stroke or high-risk transient ischemic attack.

Methods: We performed a propensity score-matched analysis from a prospective multicentric cohort study (READAPT [Real-Life Study on Short-Term Dual Antiplatelet Treatment in Patients With Ischemic Stroke or Transient Ischemic Attack]) by including patients with noncardioembolic mild-to-moderate stroke (National Institutes of Health Stroke Scale score of 0-10) or high-risk transient ischemic attack (age, blood pressure, clinical features, duration of transient ischemic attack, presence of diabetes [ABCD] ≥4) who initiated DAPT within 48 hours of symptom onset.

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Bariatric surgery does not affect kidney stone disease.

Sci Rep

December 2024

Division of General Surgery, Department of Medical-Surgical Sciences and Biotechnologies, Faculty of Pharmacy and Medicine, Bariatric Centre of Excellence SICOB, Referral Training Center of ISHAWS (Italian Chapter EHS), 'La Sapienza' University of Rome-Polo Pontino, Latina, Italy.

Background: numerous epidemiological studies demonstrate the correlation between obesity and urolithiasis. Bariatric surgery is effective in significant weight loss, reducing mortality rates, and lowering the incidence of obesity-related comorbidities. However, it may be associated with long-term complications such as urolithiasis, with an estimated increase of 7.

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Because of their sub picosecond temporal resolution, coherent Raman spectroscopies have been proposed as a viable extension of spontaneous Raman thermometry, to determine dynamics of mode specific vibrational energy content during out of equilibrium molecular processes. Here we show that the presence of multiple laser fields stimulating the vibrational coherences introduces additional quantum pathways, resulting in destructive interference. This ultimately reduces the thermal sensitivity of single spectral lines, nullifying it for harmonic vibrations and temperature independent polarizability.

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Article Synopsis
  • About 70% of bladder cancer cases are non-muscle invasive (NMIBC) and inflammation, influenced by factors like smoking, affects treatment outcomes with BCG therapy.
  • A study analyzed data from 1,313 NMIBC patients to examine how smoking and systemic inflammation impact the effectiveness of BCG using a machine-learning algorithm.
  • The results indicated that both smoking status and specific inflammatory markers can significantly predict the risk of disease progression, highlighting the need for tailored treatment strategies and further research to confirm the findings.
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Introduction: Recent advancements in single-port surgery, robotic platforms, 3D models and artificial intelligence have transformed surgical procedures, especially in urology. These innovations enhance precision, safety, and efficacy, reducing invasiveness and recovery times. The review focuses on the latest in robotic-assisted surgery for genitourinary cancers, highlighting the shift toward personalized, minimally invasive treatments.

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This study was aimed at introducing a new method for predicting the original metrics of fragmented standardized artifacts, specifically of flint blades from the Middle Pre-Pottery Neolithic B (10,200/100-9,500/400 cal B.P.) in the Southern Levant.

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Anarchy in the brain: Behavioural and neuroanatomical core of the anarchic hand syndrome.

Cortex

November 2024

NPSY.Lab-VR, Department of Human Sciences, University of Verona, Italy; IRCSS Sacro Cuore Don Calabria, Negrar, Verona, Italy.

Article Synopsis
  • Research examined three patients with different types of brain damage over 7 months, focusing on the core symptoms and underlying brain structures related to the syndrome.
  • The study found no common areas of grey matter damage among the patients, but identified similar patterns of white matter disconnections affecting communication between brain hemispheres and other areas involved in motor control.
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Patients with acute pulmonary embolism (PE) have a wide spectrum of clinical presentations, from incidental findings to sudden cardiac death. Management and treatment recommendations in currently available guidelines vary according to patient risk and haemodynamic profile. A clot-in-transit (CiT) in the right heart chambers may be occasionally identified and is, therefore, an under-recognised but challenging condition, often preceding an abrupt clinical deterioration, and associated with increased mortality.

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Geant4-DNA development for atmospheric applications: N, O and CO models implementation.

Phys Med

December 2024

Physics Dep., Sapienza U. of Rome, p.le Aldo Moro, 2, 00185, Rome, Italy; INFN, Sec. of Rome, p.le Aldo Moro, 2, 00185, Rome, Italy.

Article Synopsis
  • * New electron interaction models for nitrogen, oxygen, and carbon dioxide have been validated up to 10 MeV, which is important given carbon dioxide's role as a greenhouse gas.
  • * Results show that the models align well with existing literature, confirming their reliability and enabling further research into the effects of ionization on atmospheric chemistry and climate impacts.
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The widely utilized Global Positioning System (GPS) plays a crucial role in everyday navigation. The literature has predominantly focused on GPS use for reaching destinations rather than exploring its various strategic applications and relations with individual factors. The current paper is intended to develop a GPS Uses Scale assessing a variety of GPS uses for wayfinding and other GPS uses (Study 1).

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Skin cancers affecting the concha and antihelix are quite common, because of anterior auricular projection from the head and subsequent actinic exposure, leading to the need for effective ear reconstruction post-surgery. Various methods such as skin grafts, free tissue transplantation, and local flaps have been used. This study introduces a refined technique for concha-antihelix defect reconstruction, based on a minimally invasive modification of the revolving-door flap procedure.

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Despite a biologically established causative role of viral hepatitis (VH), i.e. HBV and HCV infections, on intrahepatic cholangiocarcinoma (ICC), only few large Western cohorts exploring the association between VH and ICC development are available.

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The present meta-analysis investigated the efficacy of intra-articular hyaluronic acid (HA) injections for knee osteoarthritis. The outcomes of interest were the visual analogue scale (VAS) and Western Ontario McMaster Osteo-Arthritis Index (WOMAC) scores. This study was conducted according to the 2020 PRISMA statement.

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