Exploring temperament and sleep patterns in disruptive mood dysregulation disorder among children and adolescents: implications for clinical practice.

Background: Disruptive Mood Dysregulation Disorder (DMDD), characterized by severe irritability and temper outbursts, is a relatively new diagnosis included in the DSM-5. The study aimed to investigate the clinical characteristics, temperament, comorbidities, medication use, and sleep quality of children and adolescents diagnosed with DMDD and compare them with Major Depressive Disorder (MDD).

Methods: A total of 233 participants (DMDD:  = 106; MDD:  = 127) were assessed using the K-SADS-PL.

Comparison of Piperacillin-tazobactam and Vancomycin (TZP-VAN) with Piperacillin-tazobactam and Teicoplanin (TZP-TEI) for the risk of Acute Kidney Injury (CONCOMITANT): A prospective observational, multinational, multi-centre cohort study.

Objectives: Both vancomycin (VAN) and teicoplanin (TEI) augment the risk of acute kidney injury (AKI) when combined with piperacillin-tazobactam (TZP). We aimed to compare the risk of AKI among patients receiving TZP-VAN versus TZP-TEI.

Methods: This was a prospective, multinational, multicentre cohort study conducted in 12 centres from Turkiye, Italy and Spain between June 1, 2022, and December 31, 2023.

Open Latarjet reduces residual apprehension, redislocation and possibility of dislocation arthropathy compared to arthroscopic Bankart repair despite greater bipolar bone loss in anterior glenohumeral instability.

Background: Arthroscopic Bankart repair (ABR) and the open Latarjet (OL) procedure are the most frequently preferred methods in the treatment of anterior glenohumeral instability. The aim of this study was to compare patients who underwent ABR or OL due to anterior glenohumeral instability in terms of functional capacity, glenohumeral bone loss, residual apprehension, redislocation, and dislocation arthropathy.

Methods: A total of 56 patients who underwent ABR or OL due to anterior glenohumeral instability between January 2018 and December 2021 were evaluated retrospectively.

Examining the relationship between adolescents' social media addiction levels and cyberbullying experiences.

Objective: The present study examines the relationship between social media addiction and cyberbullying among adolescents.

Method: This descriptive study was conducted with the participation of 1,058 adolescents aged 14 to 17, between September 1, 2018, and January 1, 2019, in the Central Anatolian region of Türkiye. Data were collected using the Adolescent Data Collection Form, the Revised Cyber Bullying Inventory II, and the Social Media Disorder Scale for Adolescents - Short Form.

Metabolic, hormonal profiles and comorbidities in pituitary Cushing's syndrome, adrenal Cushing's syndrome and mild autonomous cortisol secretion: a comparative study.

Purpose: Our study aimed to discern disparities in metabolic, hormonal profiles, and comorbidities among patients with pituitary Cushing (PC), adrenal Cushing (AC), and Mild autonomous cortisol secretion (MACS).

Methods: We conducted a retrospective analysis involving 76 patients diagnosed with PC ( = 26), AC ( = 21), and MACS ( = 29) at our clinic. We compared the groups' demographic data, clinical characteristics, biochemical profiles, hormonal analyses, and surgical interventions.

Comparison of Different Machine Learning Models for Predicting Long-Term Overall Survival in Non-metastatic Colorectal Cancers.

Introduction: In recent years, machine learning (ML) methods have gained significant popularity among medical researchers interested in cancer. We aimed to test different (ML) models to predict both overall survival and survival at specific time points in patients with non-metastatic colorectal cancer (CRC).

Methods: The clinicopathological and treatment data of non-metastatic CRC patients with more than 10 years of follow-up at a single center were retrospectively reviewed.

Changes in anaphylaxis trends and characteristics in emergency department admissions in Türkiye: From 2015 to 2021 based on the Ministry of Health database.

Background: The incidence of anaphylaxis is increasing worldwide. However, there is a lack of data on anaphylaxis trends in Türkiye. This study aims to analyse trends in anaphylaxis-related emergency department (ED) visits and examines factors associated with fatal anaphylaxis in Türkiye.

Vaccination status and hepatitis A immunity in children: insights from a large-scale study in Turkey.

Background: Hepatitis A remains a public health concern, particularly in areas with suboptimal sanitation. Introduced in Turkey's immunization schedule in 2011, the vaccine has improved immunity; however, gaps persist, especially in older, unvaccinated children. This study examines the seropositivity rates and antibody levels in children across different vaccination statuses and age groups, and to identify gaps in immunity, particularly among children those born before the introduction of the hepatitis A vaccine in Turkey.

The importance of targeted next-generation sequencing based genomic profiling in the diagnosis of childhood acute myeloid leukemia: a single center experience.

Background: The management of pediatric acute myeloid leukemia (AML) is based on the prognostic risk classification of initial leukemia. Targeted next-generation sequencing (NGS) is a reliable method used to identify recurrently mutated genes of pediatric AML and associated prognosis.

Methods: In this study, we retrospectively evaluated the prognostic, and therapeutic utility of a targeted NGS panel covering twenty-five genes, in 21 children with de novo and 8 with relapsed or secondary AML.

Metoclopramide-induced rapid-onset psychosis in a child with methylphenidate use: a case report.

Background: Metoclopramide, a dopamine antagonist employed for its antiemetic effects, can precipitate neuropsychiatric adverse effects, including extrapyramidal symptoms and, in a few instances, acute psychosis. Although there have been reports of metoclopramide-induced psychosis in elderly individuals, there is no documentation of such incidents in children as far as we are aware.

Case Presentation: This case report describes an 11-year-old girl with a history of mild intellectual disability and attention deficit hyperactivity disorder, managed with 10 mg of methylphenidate daily.

The relationship between sexual health literacy and sexual function of women with diabetes mellitus: a cross-sectional study.

Background: Sexual dysfunction (SD) is a complication of poorly managed diabetes mellitus (DM). To prevent SD, patients should develop sexual health literacy (SHL).

Objective: This study investigated the relationship between SHL and SD in women with DM.

Morphological and Anatomical Deformities of Hirudo verbana, Carena 1820 (Annelida, Hirudinea) After Feeding: Light and Electron Microscopic Analysis.

Leeches are widely used as model organisms in scientific studies and medical treatments. Medical leeches are hematophagous parasites that usually feed on the blood of their hosts. Some leeches show deformities, usually after feeding.

What is the Difference Between the Different Types of Thermometers?

Objective: There is no widely accepted method that can reflect the core temperature exactly. The aim of this study is to investigate the accuracy of frequently used body temperature measurement methods. Materials and Methods: A total of 104 patients aged 3-9 years were included in this cross-sectional study.

Early career psychiatrists' perceptions of and training experience in electroconvulsive therapy: A cross-sectional survey across Europe.

Background: Electroconvulsive therapy (ECT) is a safe and effective treatment for several major psychiatric conditions, including treatment-resistant depression, mania, and schizophrenia; nevertheless, its use remains controversial. Despite its availability in some European countries, ECT is still rarely used in others. This study aims to investigate the experiences and attitudes of early career psychiatrists (ECPs) across Europe towards ECT and to examine how their exposure to ECT influences their perceptions.

Peritoneopleuropericardial leakage confirmed with peritoneal scintigraphy in a teenage girl.

Peritoneopericardial leakage is a rare but important complication of peritoneal dialysis. Peritoneal scintigraphy is reported to be effective in diagnosing the peritoneopericardial communication. Although switching to hemodialysis is commonly recommended, reducing exchange volumes and performing peritoneal dialysis in an upright sitting position may also be considered particularly in pediatric patients.

Determination of optimal sedation depth in sleep endoscopy with bispectrometry and simultaneous polysomnography.

Objective: In this study, we aimed to evaluate the localization and configuration of vibration and obstruction in drug-induced sleep endoscopy(DISE) in obstructive sleep apnea patients and to investigate the optimal sedation depth.

Materials And Methods: The study was conducted prospectively with 42 patients. After achieving sedation with intravenous anesthetic agents, simultaneous monitoring of the patient's bispectrometry (BIS), DISE and sleep testing with a type 2 polysomnography device were performed.

Investigation of corneal topographic and ocular surface parameters in ocular rosacea based on skin subtypes.

Objective: To compare the corneal topographic parameters and ocular surface parameters of ocular rosacea (OR) patients across skin subtypes of the disease and healthy controls.

Methods: This prospective study included 180 eyes of 90 OR patients and 60 eyes of 30 healthy controls. Among the OR patients, 30 had phymatous (60 eyes), 30 had erythematotelangiectatic (60 eyes) and 30 had papulopustular skin types (60 eyes).

Large Unstained Cells (LUC): A Novel Predictor of CDK4/6 Inhibitor Outcomes in HR+ HER2-Negative Metastatic Breast Cancer.

: Although CDK4/6 inhibitors combined with endocrine therapies have improved outcomes in HR+ HER2-negative metastatic breast cancer, predictive biomarkers for treatment response and adverse effects remain limited. This study assessed the prognostic and predictive value of large unstained cells (LUC), a subset of white blood cells that may reflect immune status or treatment response. : A retrospective analysis of 210 patients with HR+ HER2-negative metastatic breast cancer treated with CDK 4/6 inhibitors between 2021 and 2024 was conducted.

Trends in prescribing montelukast in patients with asthma in real-life: Results from the Turkish adult asthma registry.

Montelukast, a leukotriene receptor antagonist (LTRA) approved for the treatment of asthma and allergic rhinitis, is widely used, though real-world data on its application in asthma management remain limited. This registry-based study evaluated the use of montelukast in adult asthma patients, examining demographic and disease characteristics, asthma control status, asthma phenotypes, presence of atopy, and treatment regimens. Among 2053 patients analyzed, 61.

Osteoperiosteal Cylindrical Iliac Bone Graft and Minced Cartilage as an Osteochondral Autograft for a Large Osteochondral Lesion.

Mosaicplasty is a relatively challenging procedure used in the management of focal osteochondral lesions of the joints. Donor-site morbidity is still the main concern after mosaicplasty because it entails the harvesting of an osteochondral autograft from an otherwise healthy region to be impacted later on the weight-bearing damaged site. We describe a possible alternative to conventional mosaicplasty with subchondral bone support harvested from the iliac crest as an osteoperiosteal autograft and covered with a minced cartilage layer.

Retrospective Evaluation of Anesthesia in Patients Undergoing Surgery after the February 6, 2023 Earthquake in Turkey.

Throughout human history, numerous natural disasters, particularly earthquakes, have caused significant destruction to civilizations. On February 6, 2023, 2 major earthquakes struck Turkey. The first occurred at 04:17 local time with a magnitude of 7.

Prognostic Implications and Predictors of Mitral Regurgitancy Reduction After Transcatheter Aortic Valve Implantation.

: Mitral regurgitation (MR) is a common condition observed in patients undergoing transcatheter aortic valve implantation (TAVI) for the treatment of aortic stenosis (AS). However, the impact of TAVI on MR outcomes and the factors predicting MR improvement remains uncertain. Understanding these predictors can enhance patient management and guide clinical decisions.

Effect of propolis supplementation on cadmium toxicity associated with renal and hepatic dysfunction in rats.

Cadmium (Cd), one of the toxic heavy metals, is of great importance for public health due to its use in many industrial areas. Propolis is a natural product with antioxidant and anti-inflammatory properties collected from plants by honey bees. The aim of this study was to investigate the protective role of propolis against the potential toxic effects of cadmium chloride in blood, liver and kidney tissues.