1,971 results match your criteria: ""San Bortolo" Hospital[Affiliation]"

Point-of-care ultrasonography (POCUS) has rapidly evolved from a niche technology to an indispensable tool across medical specialties, including nephrology. This evolution is driven by advancements in technology and the visionary efforts of clinicians in emergency medicine and beyond. Recognizing its potential, medical schools are increasingly integrating POCUS into training curricula, emphasizing its role in enhancing diagnostic accuracy and patient care.

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Background: In Italy, knee osteoarthritis (KOA) accounts for over 5 million prevalent cases and requires long-term multidisciplinary management. The most frequent KOA symptom is pain. The aim of the survey is to provide a national overview of the current management of moderate-to-severe pain associated with KOA from both clinicians' and patients' perspectives.

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Preoperative Posterior Stromal Ripples as Predictive Biomarkers of Visual Recovery After DMEK.

Cornea

September 2024

Department of Medical and Surgical Specialties, Radiological Sciences, and Public Health, Ophthalmology Clinic, University of Brescia, Brescia, Italy.

Purpose: To investigate the role of preoperative posterior stromal ripples (pre-PSR) on visual acuity recovery after Descemet membrane endothelial keratoplasty (DMEK).

Methods: This is a comparative case series retrospectively analyzing patients who underwent DMEK. Electronic records and imaging of DMEK patients were reviewed.

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Morbidity related to major lung thoracoscopic resections in children.

Pediatr Med Chir

October 2024

Department of Pediatric Surgery and Urology, Robert-Debré University Hospital, Paris, France; Paris University, Paris, France; Université Paris Diderot-Sorbonne Paris Cité, Paris.

In pediatric thoracic surgery, reported predictors for increased risk are symptoms and active/previous infections (RAP). We investigated the adverse events related to Video-Assisted Thoracic Surgery (VATS) in pediatric patients when considering RAP predictors. A retrospective analysis of pediatric VATS major lung resections in 2008-2021 was conducted at three institutions.

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Introduction: Mechanical heart valve (MHV) replacement requires long-life anticoagulation due to the risk of Prosthetic Valve Dysfunction (PVD) and cardioembolism.

Methods: We report data from a prospective observational study conducted on MHV patients in the Khartoum Salam Centre for Cardiac Surgery built by 'Emergency,' an Italian Non-Governmental Organization, to evaluate the occurrence of PVD and associated risk factors.

Results: We prospectively followed 3647 patients, and 38 patients (rate 1.

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Article Synopsis
  • Burkitt lymphoma (BL) is a common type of B-cell lymphoma in kids, with many being cured but some showing resistance to treatment.
  • Researchers used single-cell transcriptomics to study the differences between patients who respond to therapy and those who don’t, finding that non-responders have more immune cells and a specific gene, Tropomyosin 2 (TPM2), highly expressed in their tumors.
  • The study suggests that the level of TPM2 can help predict treatment outcomes for BL patients, highlighting the disease's genetic diversity and potential biomarkers for therapy resistance.
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This analysis from the GARIBALDI study was aimed to address the role of center self-declared expertise, type and commitment on the overall survival (OS) of patients with metastatic Pancreatic Ductal Adenocarcinoma (mPDAC). Treatment-naïve patients ≥18-year with pathological diagnosis of mPDAC were enrolled. OS was defined as the time from chemotherapy start to death from any cause.

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Article Synopsis
  • * In a study with 85 adults, 49.4% of patients showed at least a 90% improvement in eczema severity, while 61.2% had a favorable assessment from doctors.
  • * No major safety issues were reported, and naïve patients (those who hadn't previously tried treatment) had better outcomes than those who had failed another medication, highlighting its effectiveness in real-world settings.
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Article Synopsis
  • - The study analyzed data from 229 elderly patients with core binding factor acute myeloid leukemia (CBF-AML) to assess treatment outcomes over two decades, finding a 5-year overall survival (OS) rate of 44.2% and event-free survival (EFS) rate of 32.9%.
  • - In patients over 70 who underwent intensive therapy, those who completed treatment had a median EFS of 11.8 months and a 5-year OS of 40%.
  • - Key factors impacting survival included age, achieving remission after initial treatment, and the number of consolidation therapy cycles, indicating that intensive therapy could be beneficial for selected older patients and should not be overlooked in clinical studies. *
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Article Synopsis
  • * Recent efforts to stop smoking haven't been put into action yet, and it’s important to see what could happen if smoking rates stay the same or improve.
  • * Researchers used models to predict health outcomes by 2050 based on different scenarios of smoking rates, showing that cutting smoking could greatly improve health and life expectancy.
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Predicting the resolution of hypertension following adrenalectomy in primary aldosteronism: Controversies and unresolved issues a narrative review.

Langenbecks Arch Surg

October 2024

Centro Per Lo Studio E La Cura Dell'Ipertensione Arteriosa, Internal Medicine Unit, San Bortolo Hospital, U.L.S.S. 8 Berica, Vicenza, Italy.

Article Synopsis
  • Hypertension resolution after adrenalectomy in patients with primary aldosteronism (PA) is complex, and predicting which patients will normalize their blood pressure is both crucial and debated.
  • A thorough review of literature from 1954 to 2024 found predictors like gender, duration of hypertension, medication use, and BMI, but inconsistencies across studies led to mixed results.
  • Despite some evidence supporting predictive models for hypertension resolution, significant gaps and controversies exist, indicating a need for more research to validate and enhance these models.
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[Registers as central real world data source: the experience of the Italian Multiple Sclerosis and Related Disorders Register].

Epidemiol Prev

September 2024

Struttura Tecnico Operativa, Laboratorio di Ricerca per il Coinvolgimento dei Cittadini in Sanità, Dipartimento di Epidemiologia Medica, Istituto di Ricerche Farmacologiche Mario Negri IRCCS, Milano.

Registers collecting data from clinical practice (real world data) have gained increasing interest in recent years in the scientific, administrative, and regulatory fields. The value of longitudinal data collection in deepening knowledge about a specific pathology and its healthcare complexity is increasingly recognized. This article describes the development, organizational structure, and technical characteristics of the Italian Multiple Sclerosis and Related Disorders Register (RISM).

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The potential of retinoic acid receptors as prognostic biomarkers and therapeutic targets in gastric cancer.

Front Oncol

September 2024

Department of Medical Oncology, Centro di Riferimento Oncologico di Aviano (CRO) IRCCS, Aviano, Italy.

Article Synopsis
  • Gastric cancer is a type of stomach cancer that is really complicated and has low survival rates, but researchers are studying a vitamin-A related substance called retinoic acid to help treat it.
  • The study looked at samples from 55 patients to see how certain genes are expressed in their tumors and if these could help predict how the cancer is progressing.
  • Results showed that some gene levels were higher in patients with more serious cancer stages, which could mean that these genes might help doctors understand and treat gastric cancer better in the future.
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Importance: A multicenter randomized clinical trial (RCT) showed a lung recruitment maneuver using high-frequency oscillatory ventilation just before surfactant administration (ie, intubate-recruit-surfactant-extubate [IN-REC-SUR-E]) improved the efficacy of treatment compared with the standard intubate-surfactant-extubate (IN-SUR-E) technique without increasing the risk of adverse neonatal outcomes.

Objective: To examine follow-up outcomes at corrected postnatal age (cPNA) 2 years of preterm infants previously enrolled in an RCT and treated with IN-REC-SUR-E or IN-SUR-E in 35 tertiary neonatal intensive care units.

Design, Setting, And Participants: This was a follow-up study of infants recruited into the primary RCT from 2015 to 2018 at 35 tertiary neonatal intensive care units (NICUs) in Italy.

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Chronic kidney disease-associated pruritus (CKD-aP) is a common complication in dialysis patients which is not fully addressed by pharmacological and dialytic therapy. The objective was to review the literature on the effects of extracorporeal blood purification modalities on CKD-aP. The population comprised patients aged ≥18 years on chronic dialysis.

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Clinical Course of Neurologic Adverse Events Associated With Immune Checkpoint Inhibitors: Focus on Chronic Toxicities.

Neurol Neuroimmunol Neuroinflamm

November 2024

From the IRCCS Istituto delle Scienze Neurologiche di Bologna (S.R., R.R., M. Guarino), Italy; Reference Centre for Paraneoplastic Neurological Syndromes and Autoimmune Encephalitis (A.F), Hospices Civils de Lyon, Neurological Hospital, Bron, MeLiS - UCBL-CNRS UMR 5284 - INSERM U1314, Universitè Claude Bernard Lyon 1, France; IRCCS Mondino Foundation (A.M., L.D., E.M.), Pavia; Neurology Unit (A.D., S.M.), Department of Neurosciences, Biomedicine, and Movement Sciences, University of Verona, Italy; Neuromuscular and Rare Disease Centre (L.F.), Neurology Unit, Sant'Andrea University Hospital, Rome, Italy; Department of Neurosciences Drugs and Child Health (S.C., V.D.), University of Florence; Clinical Neurology Unit (I.F., A.V.), Department of Medicine (DMED), University of Udine; Neurology Unit (L.Z.), AULSS8 Berica, San Bortolo Hospital, Vicenza; Department of Neuroscience (M. Garibaldi, A.L.), Mental Health and Sensory Organs (NESMOS), SAPIENZA University of Rome, Sant'Andrea Hospital; Epidemiology and Statistics Unit (F.B., C.Z.), IRCCS Istituto delle Scienze Neurologiche di Bologna; Department of Neurology 2, Careggi University Hospital, Florence, Italy; Neuroimmunology Laboratory (M.Gastaldi), IRCCS Mondino Foundation, Pavia, Italy; and Clinical Neurology (A.V.), Department of Head-Neck and Neuroscience, Azienda Sanitaria Universitaria Friuli Centrale (ASUFC).

Article Synopsis
  • This study investigates the clinical characteristics of neurologic immune-related adverse events (n-irAEs) linked to immune checkpoint inhibitors (ICIs) and their potential to become chronic.
  • A total of 66 patients were analyzed, with findings showing that a significant portion experienced chronic n-irAEs, particularly affecting the peripheral nervous system and leading to various neurological impairments.
  • The study highlights that patients with concurrent myocarditis had a higher risk of fatal outcomes, and chronic n-irAEs often required ongoing treatment or resulted in persistent neurological issues like ataxia and cognitive impairment.
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Background: Post-lung transplantation (LTx) fluid accumulation can lead to dilution of serum creatinine (SCr). We hypothesized that fluid accumulation might impact the diagnosis, staging, and outcome of posttransplant acute kidney injury (AKI).

Methods: In this retrospective study, we analyzed data from 131 adult LTx patients at a single German lung center between 2005 and 2018.

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The global cases of knee osteoarthritis (KOA) are projected to increase by 74.9% by 2050. Currently, over half of patients remain dissatisfied with their pain relief.

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Article Synopsis
  • The study evaluated the use of frontline TKI therapy in elderly patients (75 years or older) with chronic phase chronic myeloid leukemia (CP-CML) among a large cohort of 332 patients.
  • Results showed that 85.8% of patients received imatinib (IM), while 14.2% were treated with second-generation TKIs (2G-TKI) like dasatinib and nilotinib, with a notable percentage starting on reduced doses.
  • The findings indicated increased usage of IM after generic versions became available in Italy, but significant discontinuation rates due to resistance and toxicities were observed, highlighting the need for personalized treatment assessments and further studies on lower TKI doses.
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