449 results match your criteria: ""Mater Domini" University Hospital[Affiliation]"

Background: Inflammatory bowel disease (IBD), encompassing ulcerative colitis and Crohn's disease, is a heterogeneous chronic condition characterized by periods of relapse and remission. Ulcerative colitis involves inflammation of the colon and rectum mucosa, while Crohn's disease causes deeper, transmural inflammation affecting all four gut layers from the mouth to the anus and can lead to complications such as fistulation. IBD significantly impacts patients' physical and psychological well-being, thus reducing their quality of life (QoL).

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Background: Failure, persistent knee instability, and reinjury rates after anterior cruciate ligament (ACL) reconstruction are still concerns. Biomechanical investigations have highlighted the role of the anterolateral ligament (ALL) as a crucial knee stabilizer, and clinical outcomes after combined ACL and ALL reconstruction appear to indicate the success of the procedure.

Purpose: To compare the functional outcomes, return-to-sport (RTS) rate, and complications between combined ACL and ALL reconstruction and isolated ACL reconstruction.

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Objectives: Primary graft dysfunction (PGD) affects survival after lung transplant (LT). The current hypothesis was that prone positioning (PP), proposed as a rescue maneuver to treat refractory hypoxemia due to PGD, may improve LT outcomes, especially when applied early.

Design: Bilateral LT recipients developing moderate-to-severe PGD within 24 hours from intensive care unit admission were enrolled.

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Objective: Ampullary neoplastic lesions can be resected by endoscopic papillectomy (EP) or transduodenal surgical ampullectomy (TSA) while pancreaticoduodenectomy is reserved for more advanced lesions. We present the largest retrospective comparative study analysing EP and TSA.

Design: Of all patients in the database, lesions with prior interventions, benign histology advanced malignancy (T2 and more), patients with hereditary syndromes and those undergoing pancreatoduodenectomy were excluded.

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Background: Data on the predictors of percutaneous stellate ganglion block (PSGB) efficacy in electrical storm are scanty.

Objective: We aimed to assess whether PSGB efficacy is influenced by the arrhythmia type and cycle length before the procedure.

Methods: This is a subanalysis of the multicenter STAR study.

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Background And Objective: Binge eating disorder (BED) is the most frequent eating disorder, often confused with obesity, with which it shares several characteristics. Early identification could enable targeted therapeutic interventions. In this study, we propose a hybrid pipeline that, starting from plasma glucose data acquired during the Oral Glucose Tolerance Test (OGTT), allows us to classify the two types of patients through computational modeling and artificial intelligence.

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Article Synopsis
  • The text refers to a correction made to a previously published article.
  • The specific article mentioned can be identified by its DOI, which is 10.1055/a-2411-1814.
  • Corrections like this are common in academic publishing to address errors or inaccuracies in research.
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Article Synopsis
  • * The disease presents symptoms like anemia and splenomegaly, with treatment options including JAK inhibitors (like Ruxolitinib) and other supportive therapies, while allogeneic stem cell transplantation is the only potential cure for eligible patients.
  • * Advances in Spatially Resolved Transcriptomics (SRT) allow for detailed analysis of gene expression in tissues, enhancing our understanding of the tumor microenvironment and cellular interactions in MF.
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Background: Anterior cruciate ligament reconstruction (ACLR) is highly recommended in patients with ACL deficiency who must perform at a high physical level. A combination of functional and psychological outcome measures is necessary to provide a comprehensive evaluation of functional status after successful return to sport after ACLR.

Purpose: To identify factors associated with higher functional outcomes among soccer players who had returned to full sports participation after ACLR.

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Background: EUS-guided gastroenterostomy (EUS-GE) is a novel and effective procedure for the management of malignant gastric outlet obstruction (GOO) with more durable results when compared to enteral stenting (ES). However, data comparing EUS-GE to ES in patients already treated with EUS-guided choledocoduodenostomy (EUS-CDS) for distal malignant biliary obstruction (DMBO) are lacking. We aimed to compare outcomes of EUS-GE and ES for the palliation of GOO in this specific population of patients.

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Article Synopsis
  • - The study investigated outcomes of lumen-apposing metal stents (LAMS) placement in patients with surgically altered anatomy (SAA), which is not well-documented in existing literature, involving 270 patients across 25 tertiary care centers up to November 2023.
  • - Technical success of the procedures was very high at 98%, with clinical success at 97%, although there was a notable adverse event rate of 12%, with various degrees of severity recorded.
  • - The results suggest that while LAMS placement in SAA is effective, due to the risk of complications, these procedures should only be performed by experienced endoscopists in specialized centers.
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Efficacy of early use of percutaneous stellate ganglion block for electrical storms.

Eur Heart J Acute Cardiovasc Care

December 2024

Division of Cardiology, Fondazione IRCCS Policlinico San Matteo, Viale Golgi 19, 27100 Pavia, Italy.

Article Synopsis
  • Electrical Storm (ES) is a critical condition that can be managed effectively using a technique called Percutaneous Stellate Ganglion Block (PSGB), which has shown positive results when used alongside standard therapy.
  • In a study analyzing 180 patients, those who received PSGB early experienced a significant reduction in arrhythmic events within the hour following the block compared to the hour before, although the overall effectiveness was similar to those who received PSGB later.
  • The findings suggest that early use of PSGB could help reduce the frequency of defibrillations and potentially lessen the risk of a more severe, refractory ES, demonstrating its effectiveness in early treatment settings.
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Background: Patient diaries are a supportive intervention aiding intensive care unit (ICU) survivors and their families post-critical illness. Despite their growing acceptance, ICU diary usage varies across settings.

Aim: This study explored themes in nurse-written ICU diaries and their impact on nursing work and communication.

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Background: Direct comparisons between [F]FDG PET/CT findings and clinical occurrence of immune-related adverse events (irAEs) based on independent assessments of clinical and imaging features in patients receiving immune checkpoint inhibitors (ICIs) are missing. Our aim was to estimate sites, frequency, and timing of immune-related PET findings during ICIs treatment in patients with melanoma and NSCLC, and to assess their correlation with clinical irAEs. Prognostic implications of immune-related events were also investigated.

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Article Synopsis
  • ARFID and food neophobia are eating disorders that create major challenges in pediatric healthcare, especially for children with food allergies, leading to serious nutritional and psychological issues.
  • The fear of allergic reactions intensifies avoidance behaviors, making it more difficult for affected children to eat a balanced diet.
  • A multidisciplinary treatment approach, incorporating therapies like CBT and FBT, along with the need for standardized protocols and more research, is crucial for improving the health and well-being of these children.
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Background: The diagnosis of anterior cruciate ligament (ACL) tear relies on clinical evaluation and magnetic resonance imaging (MRI). Direct and indirect signs of ACL tear have been described with MRI evaluation. Posterior cruciate ligament (PCL) buckling has been described as an indirect radiographic sign of an ACL tear.

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Background: Aging implies changes in terms of lung function, immune system, and respiratory and extra-respiratory comorbidities. Few studies have specifically addressed the relevance of age on severe asthma burden and control. We aimed to evaluate whether age acts as an independent determinant of asthma severity, in terms of clinical, functional, and inflammatory profile, and to explore potential cofactors that contribute to a more difficult disease control in different age groups.

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The purpose of this study was to determine the correlation between microscopic degeneration in the long head of the biceps tendon (LHBT) and the apoptotic process. This study included 26 consecutive patients who had undergone arthroscopic biceps tenodesis or tenotomy for symptomatic LHBT with or without concomitant rotator cuff tears (RCTs). Histological examination of the specimens under a light microscope was conducted after staining with hematoxylin, eosin, and the Alcian blue.

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In the global context, advancements in technology and science have rendered virtual, augmented, and mixed-reality technologies capable of transforming clinical care and medical environments by offering enhanced features and improved healthcare services. This paper aims to present a mixed reality-based system to control a robotic wheelchair for people with limited mobility. The test group comprised 11 healthy subjects (six male, five female, mean age 35.

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The i-EUS consensus on the management of pancreatic fluid collections - Part 1.

Dig Liver Dis

October 2024

Endoscopy Service, Department of Diagnostic and Therapeutic Services, IRCCS - ISMETT, Palermo, Italy.

Pancreatic fluid collections (PFCs), including pancreatic pseudocysts (PPs) and walled-off pancreatic necrosis (WON), are common complications of pancreatitis and pancreatic surgery. Historically, the treatment of these conditions has relied on surgical and radiological approaches; however, it has later shifted toward an endoscopy-based approach. With the development of dedicated lumen-apposing metal stents (LAMS), interventional Endoscopic Ultrasound (EUS)-guided procedures have become the standard approach for PFC drainage.

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Article Synopsis
  • Advanced echocardiographic imaging (AEI) techniques, like 3D echocardiography and strain analysis, provide more accurate assessments of heart function compared to traditional methods, offering better prognostic insights.
  • A national survey by the Italian Society of Echocardiography and Cardiovascular Imaging revealed varying use of AEI across 173 echo labs in Italy, categorized into low, moderate, and high-volume activity based on the number of echocardiograms performed.
  • Results showed that 3D transthoracic echocardiography was used in 75% of labs, with higher usage in high-volume centers, and strain analysis was employed by 80% of labs, indicating a trend towards more advanced imaging capabilities in
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The 1st i-EUS consensus on the management of pancreatic fluid collections - Part 2.

Dig Liver Dis

November 2024

Endoscopy Service, Department of Diagnostic and Therapeutic Services, IRCCS - ISMETT, Palermo, Italy.

Pancreatic fluid collections (PFCs), including pancreatic pseudocysts (PPs) and walled-off pancreatic necrosis (WON), are common complications of pancreatitis and pancreatic surgery. Historically, the treatment of these conditions has relied on surgical and radiological approaches. The treatment of patients with PFCs has already focused toward an endoscopy-based approach, and with the development of dedicated lumen-apposing metal stents (LAMS), it has almost totally shifted towards interventional Endoscopic Ultrasound (EUS)-guided procedures.

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Overexpression of BAG3 (Bcl2-associated athanogene 3) in serum and skin of patients with systemic sclerosis.

Clin Exp Rheumatol

August 2024

Scleroderma Clinic, UOC Clinica Reumatologica, ASST Pini-CTO, Milano, and Department of Clinical Sciences and Community Health, Università degli Studi di Milano, Italy.

Objectives: BAG3 (Bcl2-associated athanogene3) is able to induce the transformation of cancer-associated fibroblasts to alpha smooth muscle actin (a-SMA) positive (+) myofibroblasts. In systemic sclerosis (SSc), a-SMA+ myofibroblasts also play an important role in the progression of fibrosis in the skin and involved internal organs. The aim of the study was to investigate whether BAG3 is overexpressed in SSc and may be a biomarker of fibrogenesis.

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This review aims to analyze the effectiveness of motivational interviewing (MI) in enhancing therapeutic adherence and compliance in adult patients with inflammatory bowel disease (IBD), especially considering the disruptions caused by the COVID-19 pandemic. IBD, which includes conditions such as ulcerative colitis and Crohn's disease, affects over 10 million people globally. It significantly impacts both physical and psychological well-being, leading to challenges in therapeutic adherence.

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Results from the phase III clinical trial established pembrolizumab monotherapy as the first-line standard of care for patients with metastatic NSCLC who have PD-L1 expression ≥ 50%, , and wild-type tumors. However, given the differences between patients treated in routine clinical practice and those treated in a clinical trial, real-world data are needed to confirm the treatment benefit in standard practice. Given the lack of data on large cohorts of patients with long follow-ups, we designed an observational retrospective study of patients with metastatic NSCLC who were treated with pembrolizumab, starting from its reimbursement eligibility until December 2020.

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