169 results match your criteria: ""Ion Ionescu de la Brad" University of Life Sciences[Affiliation]"

Targeting Common Inflammatory Mediators in Experimental Severe Asthma and Acute Lung Injury.

Pharmaceuticals (Basel)

March 2024

Department of Preventive Medicine and Interdisciplinarity-Family Medicine Discipline, Faculty of Medicine, Grigore T. Popa University of Medicine and Pharmacy of Iasi, 16 Universitatii Street, 700115 Iasi, Romania.

Article Synopsis
  • Neutrophils play a significant role in severe asthma and acute lung injury (ALI) through IL-17 stimulation, promoting an oxidative environment.
  • The study compared the effects of Secukinumab (SECU) with Dexamethasone (DEXA) in mice with asthma exacerbated by LPS, focusing on various immune response cytokines.
  • Results showed that both treatments altered cytokine levels, with SECU uniquely inhibiting IL-5 and decreasing Th17 responses, while DEXA had different effects on Th1 and Th2 cytokines.
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The present study was conducted to investigate the effects of introducing hemp seeds, as a source of PUFAs, into a standard diet with or without dried fruit pomace (dried blackcurrant (DB) or dried rosehip (DR)), as a source of natural antioxidants, on the laying performance of hens and the FA profile, cholesterol level, antioxidant content, and lipid oxidative status in the yolks of fresh eggs or eggs stored at 4 °C for 28 days. The experiment used 128 Tetra SL hens at 35 weeks of age, which were divided into four groups and randomly assigned to four dietary treatments: a standard corn-wheat-soybean meal diet (C), standard diet containing 8% ground hemp seed (H), hemp seed diet containing 3% dried blackcurrant pomace (HB), and hemp seed diet containing 3% dried rosehip pomace (HR). The laying rate, feed conversion ratio (FCR), egg weight, and yolk weight were improved by the use of hemp seeds.

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Constant exposure to a variety of environmental factors has become increasingly problematic. A variety of illnesses are initiated or aided by the presence of certain perturbing factors. In the case of autism spectrum disorder, the environmental component plays an important part in determining the overall picture.

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Poor udder health can have a negative impact on milk production and reproductive performance, which reduces the net present value (NPV) of dairy farms. The aim of this study is therefore to investigate the relationship between clinical mastitis and NPV and the financial impact of impaired reproductive function. For this purpose, 473 dairy cows were included in our study, 146 cows with clinical mastitis (CM group) and 327 clinically healthy cows (CH group) from a high-yielding dairy farm in Romania, milking approximately 780 dairy cows with an average milk production of 46 kg milk/day.

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Degradable polymers (both biomacromolecules and several synthetic polymers) for biomedical applications have been promising very much in the recent past due to their low cost, biocompatibility, flexibility, and minimal side effects. Here, we present an overview with updated information on natural and synthetic degradable polymers where a brief account on different polysaccharides, proteins, and synthetic polymers viz. polyesters/polyamino acids/polyanhydrides/polyphosphazenes/polyurethanes relevant to biomedical applications has been provided.

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In this study, the potential use of essential oil in bio-applications was investigated. Firstly, the phytochemicals from were analyzed by different methods. Secondly, the essential oil was incorporated into the hydrogel matrix based on poly(vinyl alcohol) (PVA) and agar (A).

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Article Synopsis
  • Winery by-products from winemaking, such as pomace and skins, were historically treated as waste, leading to environmental concerns but are now being re-evaluated for their potential benefits.
  • Current research indicates these by-products are valuable sources of bioactive compounds that may offer health benefits, including antioxidant and anticancer properties.
  • The shift to a circular bioeconomy in the wine industry allows for the sustainable management of these by-products, transforming waste into high-value products for various applications.
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Article Synopsis
  • Rhododendron is a small, evergreen plant known for its vibrant flowers, and this study explores its potential to enhance yogurt's nutritional and sensory qualities using Rhododendron flower powder (RFP).
  • The research focuses on how adding RFP affects the physicochemical properties, phytochemical content, and sensory experience of yogurt, particularly looking at texture and color.
  • Results indicate that incorporating RFP not only improves yogurt's antioxidant capacity and polyphenol content but also establishes RFP as a viable functional food ingredient.
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The Effect of Municipal Biosolids on the Growth, Physiology and Synthesis of Phenolic Compounds in L.

Int J Mol Sci

December 2023

Research and Development Station for Aquaculture and Aquatic Ecology, "Alexandru Ioan Cuza" University, Carol I, 20A, 700505 Iasi, Romania.

The continuous development of drinking water networks is leading to the production of increasing amounts of waste water and sewage sludge. Secondary-treated sewage sludge is called biosolids and can be used as fertilizers in agriculture due to its rich nutrient content. The aim of this study was to evaluate the effects of biosolids mixed with an eroded soil on the morphology, physiology and synthesis of bioactive compounds in basil.

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The possibility to stimulate the production of some nutraceutical properties of fenugreek (Trigonella foenum-graecum L.) sprouts by non-thermal plasma (NTP) processing of the seeds in different conditions was studied. The non-thermal plasma used in this work was a surface dielectric barrier discharge.

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Progression of myxomatous mitral valve disease (MMVD) in dogs is a common cause of left atrial enlargement. Recently, a classification of left atrial (LA) size based on echocardiographic measurement has been proposed. This study aims to determine the radiographic LA size by reporting the cutoff values of VHS and VLAS for different groups of echocardiographic-measured LA size in dogs with MMVD.

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In this paper, the synthesis and characterization of two polycaprolactone-polydimethylsiloxane (PDMS-CL) copolymers with biodegradable properties are reported. A comparative study was carried out using an aminopropyl-terminated polydimethylsiloxane macro-initiator (APDMS) with two different molecular weights. The copolymers (PDMS-CL-1 and PDMS-CL-2) were obtained by ring-opening polymerization of ɛ-caprolactone using APDMS as initiators and stannous 2-ethylhexanoate as a catalyst.

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Pesticides vs. Biopesticides: From Pest Management to Toxicity and Impacts on the Environment and Human Health.

Toxics

December 2023

"Cristofor Simionescu" Faculty of Chemical Engineering and Environmental Protection, "Gheorghe Asachi" Technical University of Iasi, 73 Prof.dr.docent D. Mangeron Blvd., 700050 Iasi, Romania.

The environmental pollution that occurs in direct response to the widespread use of man-made/conventional pesticides results from many chemicals that require a long period of time, often decades, to degrade. The synthetic nature of pesticides also harms animals, beneficial insects, microorganisms, and plants, as well as humans. Fortunately, however, there are many natural pesticides, the so-called biopesticides, that are also effective against pests and more importantly, do not interfere with the well-being of ecosystems.

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Introduction: The need for healthy foods has become a major concern in our modern world, as the global population continues to grow and environmental challenges intensify. In response to these challenges, researchers have started to explore a range of sustainable solutions, including organic farming practices, precision agriculture, and the development and testing of innovative biofertilizers. Consistent with these ideas come the aim of this study, which sets out to give new insights into the cultivation of two sweet pepper cultivars with economic and nutritional importance in Romania.

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Preclinical Studies of Canagliflozin, a Sodium-Glucose Co-Transporter 2 Inhibitor, and Donepezil Combined Therapy in Alzheimer's Disease.

Pharmaceuticals (Basel)

November 2023

Advanced Research and Development Center for Experimental Medicine (CEMEX), Grigore T. Popa University of Medicine and Pharmacy, 16 Universitatii Street, 700115 Iasi, Romania.

The incidence of neurodegenerative diseases, such as Alzheimer's disease (AD), is continuously growing worldwide, which leads to a heavy economic and societal burden. The lack of a safe and effective causal therapy in cognitive decline is an aggravating factor and requires investigations into the repurposing of commonly used drugs. Sodium-glucose co-transporter 2 inhibitors (SGLT2i) are a new and efficient class of hypoglycemic drugs and, due to their pleiotropic effects, have indications that go beyond diabetes.

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Article Synopsis
  • The study highlights the importance of oral health as a public health issue and explores the development of silicone-based materials infused with vitamins A, B1, and B6 for use in prosthodontics to potentially enhance oral cavity treatments.
  • Various testing methods, including FT-IR spectroscopy and SEM, confirmed the successful integration of vitamins into the silicone materials, along with their biocompatibility and appropriate mechanical properties for oral applications.
  • Results showed that while the addition of vitamins improved some characteristics, it also led to decreased mechanical strength and hydrophobicity of the materials, indicating a balance needed between therapeutic benefits and material performance.
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is a highly pathogenic bacterium with high pathogenicity, that can cause serious infections in all species and especially in dogs. Treatment of the infection induced by this bacterium can be a challenge considering that some strains have developed resistance to most classes of antimicrobials. The use of bacteriophages to alleviate infections caused by has demonstrated their potential for both internal and external applications.

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The incorporation of the metal phase into cellulose hydrogels, resulting in the formation of metallogels, greatly expands their application potential by introducing new functionalities and improving their performance in various fields. The unique antiviral, antibacterial, antifungal, and anticancer properties of metal and metal oxide nanoparticles (Ag, Au, Cu, CuO, ZnO, AlO, TiO, etc.), coupled with the biocompatibility of cellulose, allow the development of composite hydrogels with multifunctional therapeutic potential.

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Integrated Assessment of Pb(II) and Cu(II) Metal Ion Phytotoxicity on L., L., and L. Plants: Insights into Germination Inhibition, Seedling Development, and Ecosystem Health.

Plants (Basel)

November 2023

Department of Environmental Engineering and Management, "Cristofor Simionescu" Faculty of Chemical Engineering and Environmental Protection, "Gheorghe Asachi" Technical University of Iasi, 73 Prof. D. Mangeron Blvd., 700050 Iasi, Romania.

Environmental pollution with heavy metals has become a problem of major interest due to the harmful effects of metal ions that constantly evolve and generate serious threats to both the environment and human health through the food chain. Recognizing the imperative need for toxicological assessments, this study revolves around elucidating the effects of Pb(II) and Cu(II) ions on three plant species; namely, L., L.

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A new approach to explore the correlation between declarative memory and anxiety in animal models of schizophrenia and microplastic pollution.

Behav Brain Res

February 2024

Doctoral School of Biology, Faculty of Biology, "Alexandru Ioan Cuza" University of Iasi, Carol I Bd., 20A, 700505 Iasi, Romania; Academy of Romanian Scientists, Splaiul Independentei no. 54, sector 5, 050094 Bucharest, Romania; Center of Biomedical Research, Romanian Academy, Carol I Bd., No 8, 010071 Iasi, Romania.

The discovery of new detrimental effects associated with microplastic pollution is ever-growing and reaching alarming rates worldwide, as it is linked to numerous disorders such as lung diseases, gastrointestinal problems, and cancer. However, a less explored issue is their impact on mental health, more precisely schizophrenia, even though several studies have shown the presence of microplastics in air, water, soil, and even food, thus making them a significant part of our daily dietary intake. It is also well known that declarative memory and anxiety levels are impaired in schizophrenia.

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A First Report of Causing Forsythia Twig Blight in Romania.

Plants (Basel)

October 2023

Department of Plant Science, Faculty of Agriculture, "Ion Ionescu de la Brad" Iasi University of Life Sciences, 3 Mihail Sadoveanu Alley, 700489 Iasi, Romania.

(Lib.) de Bary (1884) is a fungal plant pathogen with worldwide distribution and a varying host range from different botanical families. It can cause damage to a large variety of crops such as sunflower, soybean, dry bean, canola, some vegetables, and ornamental plants.

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On the 23rd of September 2022, a small intensive aquaculture unit populated with rainbow trout () reported increased mortality in adults and juvenile fish. The unit comprised 12 enclosed concrete basins with a capacity of ten cubic meters of water, populated with 150 kg of fish each. Fish were subjected to a clinical examination on the site, after which whole fish were harvested for a bacteriological and histopathological examination.

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TB therapeutic drug monitoring - analysis of opportunities in Romania and Ukraine.

Int J Tuberc Lung Dis

November 2023

Department of Clinical Pharmacy and Pharmacology, University Medical Centrum Groningen, University of Groningen, Groningen, The Netherlands, Faculty of Medicine and Health, School of Pharmacy, and, Sydney Institute for Infectious Diseases, The University of Sydney, Sydney, NSW, Westmead Hospital, Sydney, NSW, Australia.

Therapeutic drug monitoring (TDM) could improve TB treatment outcomes by avoiding drug toxicity or underdosing. In this study, we describe the patient burden in three TB centres in Romania and Ukraine with a TDM indication, as per the current guidelines, in order to estimate the feasibility of implementing TDM. A retrospective multi-centre study was conducted at the Iasi Lung Hospital (Iasi, Romania), Bucharest Marius Nasta Institute (Bucharest, Romania) and Chernivtsi TB Centre (Chernivtsi, Ukraine) in adult hospitalised TB patients.

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Given the predominantly negative impact of heavy metals on living organisms, the present study proposed to evaluate the adsorption performances under static conditions of Cd (II) from aqueous solutions on unmodified Sarkanda grass lignin compared to the adsorption performances of polysaccharide polymers chemically functionalized, obtained by synthesis and in their native state, but which, although effective, have a cost price that does not allow for large-scale expansion. To improve the retention of Cd (II) on this aromatic component of the biomass resulting from the processing of lignocellulosic materials, different experimental conditions (pH, concentration, dose and contact time) were followed. The Freundlich and Langmuir isotherms were used to describe the equilibrium conditions.

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Background: Lately, the high incidence of pesticide usage has attracted everyone's interest due to the serious effects produced. Fipronil (FIP) is a phenylpyrazole compound that acts on the insect's GABA neurotransmitter by inhibiting its activity. Moreover, the literature reports highlight its implication in neurodevelopmental abnormalities and oxidative stress production in different organisms.

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