1,095 results match your criteria: ""Gr. T. Popa" University of Medicine and Pharmacy[Affiliation]"
Medicina (Kaunas)
September 2024
Radiology and Medical Imaging Clinique, "Sf.Spiridon"Emergency Hospital, 1st Independentei Avenue, 700111 Iasi, Romania.
J Clin Med
October 2024
Department of Infectious Diseases, University of Medicine and Pharmacy "Lucian Blaga", 550169 Sibiu, Romania.
The trophoblast is a significant source of vitamin D synthesis during pregnancy, with the literature suggesting its role in fetal growth. We aim to underline a possible mechanism that would explain negative fetal outcomes in COVID-19-positive mothers by examining the relationship between altered placental structure and function and throphoblast cells' vitamin D receptor levels. The study included 170 placental samples collected from women who gave birth at term without complications, divided into three groups: COVID-19-positive and unvaccinated, COVID-19-negative and vaccinated, and COVID-19-negative and unvaccinated, with exclusion criteria for any other medical complications.
View Article and Find Full Text PDFBiomedicines
October 2024
Department of Periodontology, Faculty of Dental Medicine, Anton Sculean Research Center for Periodontal and Peri-Implant Diseases, "Victor Babes" University of Medicine and Pharmacy, 300041 Timisoara, Romania.
: Less often employed as a rinsing solution for controlling oral biofilms, NaOCL was used in oral rinses at various concentrations in steps 1 and 4 of periodontal therapy. The aim of this study was to quantitatively evaluate the biofilm-disruptive properties of a 0.2% NaOCl solution in standardized oral rinses using dedicated plaque-disclosing agents and 3D scanning methods in patients undergoing the regular Guided Biofilm Therapy protocol.
View Article and Find Full Text PDFChildren (Basel)
September 2024
Department of Mother and Child Medicine, University of Medicine and Pharmacy "Gr.T.Popa", 700115 Iasi, Romania.
Obesity, the current pandemic, is associated with alarming rises among children and adolescents, and the forecasts for the near future are worrying. The present paper aims to draw attention to the short-term effects of the excess adipose tissue in the presence of a viral infection, which can be life-threatening for pediatric patients, given that the course of viral infections is often severe, if not critical. The COVID-19 pandemic has been the basis of these statements, which opened the door to the study of the repercussions of obesity in the presence of a viral infection.
View Article and Find Full Text PDFInt J Biol Macromol
November 2024
Center for Low-temperature Plasma Sciences, Nagoya University, Furo-cho, Chikusa-ku, Nagoya 464-8601, Japan.
Plasma-activated chitosan (PAC) colloids for cancer treatment were obtained by using the cold atmospheric plasma technique. Chitosan solutions were irradiated by plasma ignited in argon gas and in a mixture of argon with nitrogen and oxygen gases in certain ratios. The structural modifications of chitosan and the chemical species generated in plasma were investigated by EPR, LC-MS/MS, XRD, DLS, and TGA methods.
View Article and Find Full Text PDFJ Clin Med
September 2024
Department of Infectious Diseases, University of Medicine and Pharmacy "Lucian Blaga", 550169 Sibiu, Romania.
Diseases
September 2024
Faculty of General Medicine, University of Medicine and Pharmacy "Gr. T. Popa", Iași 700115, Romania.
Background: Despite worldwide vaccination efforts, Hepatitis B virus (HBV) infection remains a significant global health burden, particularly in regions where vertical transmission is prevalent. Given Romania's history as an endemic area for hepatitis B from the 1990s until the early 2000s and the previously high infection rates among children, it is crucial to continually evaluate HBV infection in this population to monitor current trends, assess the long-term impact of vaccination programs, and address any remaining gaps in prevention and treatment efforts. This study aims to identify childhood risk factors associated with HBV acquisition, examining the role of maternal HBV status in child HBV infection, focusing on vertical transmission among a cohort of 654 children, with maternal infection as the independent variable and child infection as the dependent variable.
View Article and Find Full Text PDFJ Voice
September 2024
Department of Morphofunctional Sciences, Chair of Anatomy and Embriology, Grigore T Popa University of Medicine and Pharmacy Iași, Iași, Romania.
Exp Ther Med
November 2024
Department of Obstetrics and Gynecology, St. Luke's Hospital, R95 FY71 Kilkenny, Republic of Ireland.
Cognitive decline is a frequent complaint in healthy controls and neurological patients, regardless of the underlying pathology. Whilst cognitive impairment can be easily diagnosed in the more advanced stages of neurodegenerative diseases, early detection can be challenging. This is mainly the consequence of the incomplete understanding of the underlying pathophysiological mechanisms.
View Article and Find Full Text PDFPharmaceutics
July 2024
Department of Pharmaceutical Technique, University of Medicine and Pharmacy, Discipline of Anatomy, 200349 Craiova, Romania.
J Clin Med
August 2024
George Emil Palade University of Medicine, Pharmacy, Science and Technology of Tîrgu Mureș, 540142 Tîrgu Mureș, Romania.
: The diet and physical activity of the world's population determine the increase in the number of bariatric surgeries. The most common types of bariatric surgery are laparoscopic sleeve gastrectomy (LSG) and Roux-Y gastric bypass (RYGB). Surgical interventions are carried out in patients with numerous comorbidities, among which the most common are cardiovascular diseases.
View Article and Find Full Text PDFJ Clin Med
August 2024
Department of Obstetrics and Gynecology, University of Medicine and Pharmacy 'Gr. T. Popa', 700115 Iasi, Romania.
(1) The three factors within the Virchow triad play the leading role in the development of deep vein thrombosis (DVT) during pregnancy. (2) This research approaches the various risk factors associated with DVT and its most representative complications, pulmonary thromboembolism and cerebral venous thrombosis, in pregnant and postpartum women across a 15-year period (2007-2021). (3) A total of 201 out of 287 patients with DVT had associated risk factors, while 86 did not present with any.
View Article and Find Full Text PDFSci Rep
August 2024
Ophthalmology Department, Faculty of Medicine, University of Medicine and Pharmacy "Gr. T. Popa" Iasi, University Street No 16, 700115, Iasi, Romania.
In ophthalmology, artificial intelligence methods show great promise due to their potential to enhance clinical observations with predictive capabilities and support physicians in diagnosing and treating patients. This paper focuses on modelling glaucoma evolution because it requires early diagnosis, individualized treatment, and lifelong monitoring. Glaucoma is a chronic, progressive, irreversible, multifactorial optic neuropathy that primarily affects elderly individuals.
View Article and Find Full Text PDFMedicina (Kaunas)
June 2024
2nd Morpho-Functional Department, Biophysics and Medical Physics, "Gr.T.Popa" University of Medicine and Pharmacy, 16 Universitatii Street, 700115 Iasi, Romania.
: Job strain is a psychological, physical, and behavioral stress that occurs at the workplace. Job strain is associated with more than double the normal risk of coronary artery disease (CAD). The main aim of this study was to determine the association between job strain and the following parameters: high-sensitivity C-reactive protein (hs-CRP), the albumin urine excretion rate (AUER), and secondary-level testing.
View Article and Find Full Text PDFJ Clin Med
July 2024
Faculty of General Medicine, University of Medicine and Pharmacy "Gr. T. Popa", 700115 Iași, Romania.
: Liver cirrhosis presents significant challenges in the pediatric population due to a complex interplay of etiological factors, clinical manifestations, and limited therapeutic options. The leading contributors to cirrhosis among pediatric patients are chronic cholestasis, metabolic disorders present from birth, and long-term hepatitis. : Our narrative review aimed to synthesize literature data on the etiology, clinical picture, diagnostic techniques, optimal management of complications, and timely transplantation.
View Article and Find Full Text PDFBiomedicines
July 2024
Faculty of General Medicine, University of Medicine and Pharmacy "Gr. T. Popa", 700115 Iași, Romania.
Antibiotics (Basel)
June 2024
Department of Infectious Diseases (Internal Medicine II), Faculty of Medicine, University of Medicine and Pharmacy "Gr. T. Popa", 700115 Iasi, Romania.
Background: The aim of our study was to analyze the factors associated with the increased risk of urinary tract infection (UTI) with carbapenem-resistant (CR) () and the antibiotic resistance spectrum of the strains in patients. As secondary objectives, we elaborated the profile of these patients and the incidence of different types of carbapenemases.
Methods: We conducted a retrospective case-control study in which we compared a group of 62 patients with urinary tract infections with CR with a control group consisting of 136 patients with urinary tract infections with multidrug-resistant (MDR), but carbapenem-sensitive (CS), , who were hospitalized between 1 January 2022 and 31 March 2024.
Cureus
June 2024
Department of Internal Medicine, Jinnah Sindh Medical University, Karachi, PAK.
Premenstrual dysphoric disorder (PMDD) is a severe variant of premenstrual syndrome (PMS), categorized as a mood disorder due to marked symptoms of depression and anxiety, compounded with severe physical symptoms. Female sexual dysfunction (FSD) can manifest as low libido, difficulty achieving sexual pleasure, and dyspareunia, causing functional and psychological distress. PMDD and FSD are globally prevalent conditions with postulated biological, psychological, and social associations between them.
View Article and Find Full Text PDFJ Clin Med
June 2024
Department of Obstetrics and Gynecology, University of Medicine and Pharmacy "Gr. T. Popa", 700115 Iasi, Romania.
: The infrequent occurrence of pyoderma gangrenosum (PG) during pregnancy and in postpartum, with its subsequent diagnostic intricacies, caused us to present the following case. : This article describes a rare case of PG in postpartum in a patient without any prior pathology and a short review of the literature, aiming to identify similar rare instances. : We conducted a literature review to ascertain the prevalence of postpartum pyoderma gangrenosum, and we identified a total of 41 cases.
View Article and Find Full Text PDFPostgrad Med
August 2024
Department of Electrical Measurements and Materials, Faculty of Electrical Engineering and Information Technology, Gheorghe Asachi Technical University of Iasi, Iasi, Romania.
With a constant increase in prevalence and incidence worldwide, stroke remains a public health issue in the 21 century. Additionally, population aging inevitably leads to increased vulnerability in the general population, a clinical state known as frailty. While there are adequate guidelines on the treatment of stroke in the acute setting, there are a lot of gaps regarding the chronic management of stroke patients, particularly the frail ones.
View Article and Find Full Text PDFPolymers (Basel)
June 2024
Department of Plastic Surgery and Reconstructive Microsurgery, "Sf. Spiridon" Emergency County Hospital Iasi, "Gr. T. Popa" University of Medicine and Pharmacy Iasi, Bulevardul Independentei No. 1, 700115 Iasi, Romania.
The antifungal agent, ketoconazole, and the anti-inflammatory drug, piroxicam, were incorporated into matrices of xanthan or oleic acid-esterified xanthan (Xn) and polyurethane (PU), to develop topical drug delivery systems. Compared to matrices without bioactive compounds, which only showed a nominal compressive stress of 32.18 kPa (sample xanthan-polyurethane) at a strain of 71.
View Article and Find Full Text PDFAnn Surg Oncol
October 2024
Department of Surgery, Erasmus MC Cancer Institute, Rotterdam, The Netherlands.
Background: Resection of perihilar cholangiocarcinoma (pCCA) is a complex procedure with a high risk of postoperative mortality and early disease recurrence. The objective of this study was to compare patient characteristics and overall survival (OS) between pCCA patients who underwent an R1 resection and patients with localized pCCA who received palliative systemic chemotherapy.
Methods: Patients with a diagnosis of pCCA between 1997-2021 were identified from the European Network for the Study of Cholangiocarcinoma (ENS-CCA) registry.
Medicina (Kaunas)
April 2024
Department of Pharmacology, "Gr T Popa" University of Medicine and Pharmacy, Universitatii 16, 700115 Iasi, Romania.
: The influence of montelukast (MK), an antagonist of cysLT1 leukotriene receptors, on lung lesions caused by experimental diabetes was studied. : The study was conducted on four groups of six adult male Wistar rats. Diabetes was produced by administration of streptozotocin 65 mg/kg ip.
View Article and Find Full Text PDF