817 results match your criteria: ""G. Papanikolaou" General Hospital[Affiliation]"

Prevalence of SARS-COV-2 infection and outcomes in Greek sarcoidosis patients.

Sarcoidosis Vasc Diffuse Lung Dis

December 2024

Department of Respiratory Medicine, Faculty of Medicine, School of Health Sciences, University of Thessaly, Larissa, Greece.

Background And Aim: There is limited data on the prevalence of SARS-COV-2 in sarcoidosis patients and the underlying parameters linked to severity. We aimed to conduct a national multicenter study to explore the prevalence of SARS-COV-2 in sarcoidosis patients and investigate its impact on hospitalization and infection rates, describe the characteristics of the infected population and assess the role of these characteristics in determining the likelihood of infection or hospitalization.

Methods: We recruited all the adult sarcoidosis patients with who were examined across eight Greek Health Interstitial Lung Disease Referral Centers from the beginning of the pandemic until August 1, 2022.

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Article Synopsis
  • A 56-year-old woman with a history of papillary thyroid carcinoma presented with a rare case of metastasis to her left parotid gland after many years since her initial treatments.
  • Imaging and biopsy confirmed the metastasis, leading to a total parotidectomy and further radioactive iodine therapy.
  • The case highlights the importance of awareness and a collaborative approach in diagnosing and treating rare distant metastases, which can significantly impact patient outcomes.
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Introduction: Littoral cell angioma (LCA) is a new subtype of vascular tumor, which has been reported infrequently worldwide. It is associated with visceral malignancies and other immunologic conditions.

Clinical Case: We present a case of a 70-year-old Caucasian male with a 6-year history of myelodysplastic syndrome, which was investigated for splenomegaly and pancytopenia.

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Perineal Rectosigmoidectomy (Altemeier's Procedure) in the Treatment of Strangulated Rectal Prolapse: A Case Series and Literature Review.

J Pers Med

November 2024

4th Department of Surgery, General Hospital of Thessaloniki "G. Papanikolaou", School of Medicine, Faculty of Health Science, Aristotle University of Thessaloniki, 541 24 Thessaloniki, Greece.

Background: Rectal prolapse (RP) predominantly affects women over the age of 50 and presents as mucosal, internal, or full thickness prolapse. Strangulated rectal prolapse requires immediate medical intervention, and surgical treatment options include both abdominal and perineal approaches. We aim to present a case series of perineal rectosigmoidectomy performed urgently due to strangulation and argue that Altemeier's procedure is the preferred method for treating strangulated rectal prolapse.

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Fibrolipomatous hamartomas of the median nerve are rare, benign tumors characterized by the overgrowth of fibro-fatty tissue within the nerve sheath, often leading to nerve compression. This report presents 2 cases: a 33-year-old man with a gradually enlarging wrist mass and a 48-year-old woman, initially diagnosed with De Quervain's tenosynovitis for radial pain, who was found to have an incidental fibrolipomatous hamartoma on MRI. In both cases, MRI played a pivotal role in diagnosis, revealing characteristic features that enabled a definitive, noninvasive diagnosis.

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Article Synopsis
  • The STEPINCOPD study investigated the factors influencing the escalation or de-escalation of inhaled COPD therapies in clinical practice, especially after updated guidelines were released in 2019 and 2020.
  • Conducted over 12 weeks with 1429 patients from various centers in Greece, the study focused on understanding why patients had changes in their inhaled medication based on GOLD's 2021 recommendations.
  • Findings revealed that reasons for treatment changes included lack of response to previous treatment and COPD exacerbations, with a high adherence rate (over 80%) to the GOLD recommendations among physicians, influenced by factors such as their age and patients' CAT scores.
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  • The report discusses a case of a 48-year-old patient with pre-extensively drug-resistant tuberculosis (XDR tb) who died from myocarditis following a complex treatment regimen.
  • The patient's history of poor adherence to medication resulted in acquired resistance to both first- and second-line drugs, complicating her condition.
  • This case highlights a potentially lethal side effect of drug treatment for resistant tb, urging clinicians to be vigilant about the risk of drug-induced myocarditis in similar patients.
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  • Aging affects how driving pressure impacts mortality in patients with ARDS, particularly highlighting that this relationship may be stronger in older individuals, especially those aged 80 and above.!* -
  • A study analyzed data from over 4,500 ARDS patients and found that the difference in driving pressure between those who survived and those who did not varied significantly with age, indicating a critical age-related factor in mortality risk.!* -
  • The results suggest that a personalized approach to mechanical ventilation based on a patient's age could be beneficial for managing ARDS, as certain thresholds for driving pressure may have different implications for older populations.!*
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Background: Idiopathic pulmonary fibrosis (IPF) is a lethal interstitial disease with unknown etiology and no effective cure, posing a great health burden to society. Erythropoietin (EPO) has been demonstrated to have protective roles in various tissues such as brain, spinal cord, heart, kidney and lung tissues. In this study, we investigate the specific anti-inflammatory, antioxidant and antiapoptotic effects of erythropoietin on lung tissue in a bleomycin-induced rat model of idiopathic pulmonary fibrosis.

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Presepsin Levels in Infection-Free Subjects with Diabetes Mellitus: An Exploratory Study.

Biomedicines

August 2024

Second Propedeutic Department of Internal Medicine, Hippokration General Hospital, Aristotle University of Thessaloniki, 546 42 Thessaloniki, Greece.

Article Synopsis
  • * A study with 75 individuals highlighted that the duration of diabetes affected presepsin levels, with type 1 diabetes patients showing higher levels compared to type 2 diabetes patients, especially in well-controlled groups.
  • * After considering other factors like age and body mass index, the difference in presepsin levels remained significant, indicating its possible role as a marker for inflammation in diabetes management.
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This case report outlines the diagnostic and therapeutic challenges encountered in a man in his 70s suffering from knee septic arthritis caused by It is the second published case in the literature with osteoarticular infection from and the first one in the last 40 years. Following knee arthroscopy, the patient experienced persistent pain, swelling and discomfort, prompting further investigation. Postoperative knee cultures were negative for infection, but symptoms were not ameliorated.

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Effect of adequacy of empirical antibiotic therapy for hospital-acquired bloodstream infections on intensive care unit patient prognosis: a causal inference approach using data from the Eurobact2 study.

Clin Microbiol Infect

December 2024

OUTCOMEREA Research Group, Drancy, France; Institut National de la Santé et de la Recherche Medicale, Infection Antimicrobial Modelisation Evolution, U1137, Team Decision Science in Infectious Diseases, Paris, France; Assistance Publique Hôpitaux de Paris, Bichat hospital, Medical and infectious diseases ICU, F75018, Paris France. Electronic address:

Article Synopsis
  • Hospital-acquired bloodstream infections (HA-BSI) in ICU patients can be life-threatening, and this study aimed to see how early adequate antibiotic treatment affects 28-day mortality rates for patients who survive at least one day after infection onset.
  • Using data from a multicenter study with 2,418 patients, researchers found that those who received adequate treatment within 24 hours had a lower 28-day mortality rate (32.8%) compared to those who were inadequately treated (40%).
  • The study concluded that inadequate antibiotic therapy within 24 hours contributes significantly to 28-day mortality, indicating that quicker treatment could greatly improve patient outcomes in cases of HA-BSI.
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According to the European Union (EU) Directive 2005/36, the medical specialty of oral and maxillofacial surgery (OMFS) exists with two possible formats: dual degree OMFS called Dental, Oral and Maxillofacial Surgery (DOMFS) - basic medical and basic dental training and single medical degree Maxillofacial Surgery (MFS). Within the EU and across all of Europe, differences in the nature and quality of OMFS training coexist. By implementing the highest possible standards of training, patient care can be improved.

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Two Cases of Testicular Tuberculosis and Review of the Recent Literature.

Int J Mycobacteriol

July 2024

Pulmonary Department, Respiratory Infections Unit, "G. Papanikolaou" General Hospital, Aristotle University of Thessaloniki, Thessaloniki, Greece.

In this review, two cases of testicular tuberculosis (TB) are presented, and another 58 cases published in PubMed between January 1, 2012, and July 31, 2023, are reviewed. Testicular TB remains a disease mainly of the developing world, with one notable exception - the infections caused as a result of Bacillus Calmette-Guérin infusion immunotherapy for bladder cancer. Its clinical course is subacute; however, it might get disseminated and become life-threatening; therefore, prompt diagnosis is very important.

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The aim of this study is to evaluate the safety and efficacy of the use of the IMACTIS CT-Navigation™-electromagnetic navigation system (EMNS) in cryoablation CT-guided procedures under local anesthesia for the treatment of upper kidney pole and adrenal lesions. We conducted a retrospective analysis of patients with upper kidney pole lesions and adrenal metastases who underwent cryoablation using the IMACTIS-CT-EMNS between January 2019 and April 2023. The EMNS was used to guide the placement of the cryoprobes with CT guidance under local anesthesia.

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Osteoid osteomas are benign bone tumors characterized by severe localized pain, often challenging the daily lives of young patients. While these tumors are typically solitary, rare cases of multiple osteoid osteomas have been reported. This research paper presents a case series of 2 young patients with multiple osteoid osteomas, highlighting their clinical presentation, diagnostic workup, treatment with cryoablation, and follow-up.

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Echinococcosis presents diverse clinical manifestations, including pulmonary hydatidosis, often asymptomatic but complicated by rare yet dramatic occurrences like hydatoptysis. Here, we report a unique case of recurrent pulmonary and abdominal hydatidosis in a 59-year-old female with bronchial fistulization and hydatoptysis, despite previous surgical interventions. Imaging revealed characteristic features aiding in diagnosis and management decisions.

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The Interactions between Smoking and Sleep.

Biomedicines

August 2024

Respiratory Failure Clinic and Sleep Laboratory, General Hospital of Thessaloniki "G. Papanikolaou", Aristotle's University of Thessaloniki, 54642 Thessaloniki, Greece.

Smoking a cigarette before bed or first thing in the morning is a common habit. In this review, the relationship between smoking and sleep is investigated based on the existing literature. Out of 6504 unique items that were identified via a PubMed search related to smoking and sleep, 151 were included in this review.

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Background: Factors associated with severe COVID-19 infection have been identified; however, the impact of infection on longer-term outcomes is unclear. The objective of this study was to examine the impact of COVID-19 infection on the trajectory of lung function and nutritional status in people with cystic fibrosis (pwCF).

Methods: This is a retrospective global cohort study of pwCF who had confirmed COVID-19 infection diagnosed between January 1, 2020 and December 31, 2021.

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Article Synopsis
  • The study aimed to compare the impacts of Obstructive Sleep Apnea Syndrome (OSAS) and Obesity Hypoventilation Syndrome (OHS) on physical activity, mental health, and quality of life among obese patients, the first of its kind in literature.
  • A total of 76 obese patients (48 with OSAS and 26 with OHS) underwent various assessments, including physical activity and mental health questionnaires, revealing that both groups experienced similar mental health outcomes but differed significantly in physical activity levels.
  • Findings indicated that while both conditions impair quality of life, patients with OHS faced a greater reduction in daily physical activity compared to those with OSAS, potentially linked to complications like daytime hypercapnia.
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Background: The extrafine single inhaler triple therapy (efSITT) containing beclomethasone dipropionate/formoterol fumarate/glycopyrronium 87/5/9 μg has proved to be efficacious in patients with chronic obstructive pulmonary disease (COPD) in randomized control trials.

Objective: TRIWIN study evaluated the effectiveness of efSITT delivering beclomethasone dipropionate/formoterol fumarate/glycopyrronium 87/5/9 μg in COPD patients previously treated with multiple-inhaler triple therapy (MITT) in a real-world study in Greece.

Design: Prospective, multicenter, observational, non-interventional study was conducted over 24 weeks.

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Small airways disease in chronic obstructive pulmonary disease.

Expert Rev Respir Med

July 2024

Division of Lung and Airway Research, Institute of Environmental Medicine, Karolinska Institutet, Stockholm, Sweden.

Introduction: Small airway disease (SAD) represents a common and critical feature of Chronic Obstructive Pulmonary Disease (COPD). Introduced in the '60s, SAD has gradually gained increasing interest as assessment methodologies have improved. Chronic exposure to smoking and noxious particles or gases induces inflammation and remodeling, leading to airway obstruction and SAD, eventually resulting in complete airway loss.

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