Is the Otolithic Function Affected in Patients with Obstructive Sleep Apnea Syndrome?

Background:  While cardiovascular and neurological diseases induced by obstructive sleep apnea syndrome (OSAS) hypoxia are well established, the association between neuro-otological diseases and OSAS is not entirely understood. Vestibular and audiological tests have been used to evaluate the degeneration of neurons in the brainstem caused by recurrent hypoxia.

Purpose:  Evaluation of the vestibular-evoked myogenic potential (VEMP) test findings applied to detect the possible influence on the vestibular reflex arc due to hypoxia in patients diagnosed with OSAS using Activity-Specific Balance Confidence (ABC) and Berg Balance Scale (BBS) scales determination of scores.

Virtual Reality Interventions and Psychosocial Functioning in Schizophrenia Spectrum Disorders: A Systematic Review.

Objective: The objective of this study is to evaluate the effectiveness of virtual reality (VR) intervention programs that aim to improve psychosocial functioning in schizophrenia spectrum disorders and evaluate the quality assessment of these studies.

Methods: PRISMA (Preferred Reporting Items for Systematic reviews and Meta-Analyses) guideline was followed to conduct this systematic review. The literature search was performed in Web of Science (WoS) and PubMed, by two independent researchers on two occasions, on 1 March 2023 and 20 August 2023.

Evaluation of Motor Skills With Functional Dexterity Test in Children With ADHD and Comparison With Healthy Controls.

Objective: The study aimed to investigate whether the fine motor skills measured by the Functional Dexterity Test (FDT) in ADHD children differ from healthy controls. The second aim was to assess the applicability of the FDT assessment method among ADHD children.

Method: The FDT results as an objective assessment of hand skills were compared between 7 and 17 years old ADHD cases ( = 146) and age and gender-matched healthy controls ( = 213).

Risk factors for neurologic sequelae in children and adolescents with hemophilia after intracranial hemorrhage.

Background: Intracranial hemorrhage (ICH) is reportedly rare but has high morbidity and mortality risk in persons with hemophilia. Although the risk factors that facilitate bleeding are known, the factors affecting the sequelae are not well known.

Objectives: We planned to investigate the risk factors for neurologic sequelae in children and adolescents with hemophilia suffering from ICH.

Low-cost, mobile EEG hardware for SSVEP applications.

The global shortage of integrated circuits due to the COVID-19 pandemic has made it challenging to build biopotential acquisition devices like electroencephalography (EEG) hardware. To address this issue, a new hardware system using common ICs has been designed, which is cost-effective, precise, and easily accessible from global distributors. The hardware system comprises 8-channel inputs EEG hardware with a mobile headset capable of acquiring 5-30Hz EEG signals.

Efficacy and Safety of CT-P13 as First- and Second-Line Treatment in Patients with Ankylosing Spondylitis.

CT-P13 is a biosimilar version of infliximab, a monoclonal antibody. In individuals with ankylosing spondylitis (AS), CT-P13 has been shown to be effective and to have a well-tolerated safety profile. The aim of this study was to evaluate the long-term drug persistence, safety, and efficacy of infliximab biosimilar CT-P13 in patients with AS undergoing first-line (1st-line) and later (≥2nd-line) treatment in clinical practice.

The Effect of Fluid Restriction and Intake Conditions on the Shooting Performance of Competitive Adolescent Handball Players.

(1) Background: This study aimed to investigate the effects of fluid restriction and intake (water vs. sports drink) on shooting accuracy and speed in adolescent handball players, a population with high sensitivity to hydration levels yet understudied in this context. (2) Methods: A total of 47 adolescent competitive handball players (15.

Correlation and Agreement Between the SCORE2 and PREVENT 10-Year Atherosclerotic Cardiovascular Disease Risk Scores: Insights from Coronary Computed Tomography Angiography.

: We aimed to evaluate the correlation and agreement between the Systemic Coronary Risk Estimation 2 (SCORE2) and Predicting Risk of CVD EVENTs (PREVENT) 10-year ASCVD risk scores by incorporating computed tomographic (CT) data to assess differences between the scoring systems. : The PREVENT risk score was calculated for 171 patients, while the SCORE2 and SCORE2 Older Persons (OP) risk scores were calculated for 113 patients. Coronary artery calcium (CAC) scores were calculated, and the grading of coronary artery disease (CAD) was assessed according to these scores.

Life-History Traits of Nikolsky, 1905 from Northeastern Anatolia.

In this study, the life-history traits of are presented for the first time. A total of 27 samples (17 ♂♂ and 10 ♀♀) from Iğdır Province, Türkiye, were aged using skeletochronology. Student's -test was performed to compare mean differences in the variables between sexes.

Dealing With the Complexity of Effective Population Size in Conservation Practice.

Effective population size () is one of the most important parameters in evolutionary biology, as it is linked to the long-term survival capability of species. Therefore, greatly interests conservation geneticists, but it is also very relevant to policymakers, managers, and conservation practitioners. Molecular methods to estimate rely on various assumptions, including no immigration, panmixia, random sampling, absence of spatial genetic structure, and/or mutation-drift equilibrium.

The effect of osteoporosis education on osteoporosis knowledge level and daily life in Parkinson's disease patients: A 12-week, randomized-controlled trial.

Objectives: This study aims to evaluate the effect of osteoporosis education on osteoporosis knowledge level (OKL) and behavioral changes in daily life in patients with Parkinson's disease (PD).

Patients And Methods: Between May 2019 and December 2019, a total of 54 patients (34 males, 20 females; median age: 68.5 years; range, 50 to 87 years) were included in the study.

Fabrication of Bioactive Extract-Loaded Chitosan-Based Bilayer Wound Dressings for Skin Tissue Regeneration.

In recent years, there has been a notable shift toward exploring plant and animal extracts for the fabrication of tissue engineering structures that seamlessly integrate with the human body, providing both biological compatibility and physical reinforcement. In this particular investigation, we synthesized bilayer wound dressings by incorporating snail () secretions, comprising mucus and slime, into chitosan matrices via lyophilization and electrospinning methodologies. A nanofiber layer was integrated on top of the porous structure to mimic the epidermal layer for keratinocyte activity as well as acting as an antibacterial barrier against possible infection, whereas a porous structure was designed to mimic the dermal microenvironment for fibroblast activity.

Agreement Between Office-Based and Laboratory-Based Globorisk Models and their Prediction of Cardiovascular Diseases in Turkish Population: A Nationwide Cohort Study.

Globorisk is a country-specific risk prediction model that estimates 10-year cardiovascular disease (CVD) risk. This study aims to evaluate the agreement between different versions of Globorisk and their ability to predict CVD in a nationwide Turkish cohort. Baseline data from 5449 participants aged 40-74 were obtained from Türkiye Chronic Diseases and Risk Factors Survey 2011.

Association of febrile neutropenia episodes and blood product transfusions in children with acute leukemia.

Objective: Transfusion is vital supportive therapy in leukemias, but has significant potential febrile complications. In this study, we aimed to reveal the possible effects of blood product transfusions on febrile neutropenia episodes (FNEs) in children with acute leukemia.

Methods: We obtained the relevant clinical and laboratory data from the medical records.

A simple and efficient "cell in situ collagen zymography" technique to evaluate cellular collagenase activities in thyroid cancer cell lines.

Background: Collagenases, a subgroup of matrix metalloproteinases (MMPs), play crucial roles in local invasion and metastasis in cancer. While substrate zymography and in situ zymography are commonly used to analyze the collagenases, traditional techniques have limitations in determining their local activities in vitro.

Objectives: We aimed to develop a new "cell in situ collagen zymography" technique to enhance the efficiency of studying local collagenase activities in vitro.

Gastroprotection in Heart Failure and Outcomes: A Systematic Review of Proton Pump Inhibitors and Histamine-2 Receptor Antagonists.

Purpose: The management of heart failure (HF) frequently includes gastroprotection via proton pump inhibitors (PPIs) or histamine-2 receptor antagonists (H2RAs). This systematic review evaluates their impact on HF outcomes, including exacerbation, hospitalization, mortality, and major adverse cardiac events (MACE).

Methods: In accordance with PRISMA guidelines, a complete search across databases such as PubMed/Medline, Scopus, and Web of Science was conducted until December 10, 2023.

Effect of Bacillus Calmette-Guérin Instillation Timing on Oncological Survivals After Transurethral Resection of Bladder Tumor.

Objective: To investigate whether the timing of bacillus Calmette-Guerin instillation (TTBCG), which plays a key role in treating non-muscle invasive bladder cancer (NMIBC), after transurethral resection of bladder tumor (TURBT) affects oncologic outcomes.

Methods: Patient data obtained from the Urologic Cancer Database-Bladder (UroCaD-B) of Turkish Uro-oncology Association (TUOA) were evaluated. Data from 292 patients from 12 centers with primary T1HG treated with TURBT and maintenance BCG between 2003 and 2023 were retrospectively analyzed.

Remplissage Using Tendon Graft Can Improve Impaired Suction Seal Caused by Over-resection During Femoroplasty in an Ovine Model.

Purpose: To evaluate the effect of depth and location of femoral osteoplasty or the use of remplissage on the suction seal in a sheep hip model.

Methods: The hips of 32 twelve-month-old sheep were used as a cam-type femoroacetabular impingement model. The subjects were divided into 4 groups, each undergoing a distinct surgical procedure: group I underwent a 5% cam resection at the head/neck junction, group II had a 10% cam resection at the head/neck junction, group III received a 5% cam resection from 5 mm proximal to the head/neck junction, and group IV underwent remplissage to replace the loss of the suction seal with an extensor tendon graft in the defected area after a 10% cam resection at the head-neck junction.

Finite element analysis of intramedullary nailing and nail-plate combinations for treating unstable proximal tibial metaphyseal fractures.

Background: The anatomy of the proximal tibia presents treatment challenges, and there is currently no widely accepted surgical fixation method for fractures in this region. The aim of this study is to evaluate the efficacy, benefits, and differences between intramedullary nailing (IMN) with a 4-hole Limited Contact Dynamic Compression Plate (LC-DCP) combination and IMN with an 8-hole LC-DCP combination in unstable fractures of the proximal metaphyseal region of the tibia.

Methods: An oblique fracture was created in the metaphyseal region, forming a 30-degree angle in the sagittal plane in three tibial models.

Accelerometer-measured physical activity patterns in daily life and their association with factors of sedentary behavior in people with epilepsy.

Objectives: Being physically active is important, but people with epilepsy (PWE) tend to have a sedentary lifestyle. There is limited evidence about physical activity patterns in PWE using objective measures. The aims of this study were: (1) to examine the physical activity patterns of PWE, (2) compare activity patterns between PWE in terms of drug-resistant epilepsy and medically controlled epilepsy with age- and sex-matched healthy controls; and (3) explore the association between physical activity patterns and body function and structure, activity and participation, and quality of life of PWE.

Hospitality Venues' Anti-tobacco Legislation Violation in 11 Different Cities in Türkiye.

In Türkiye, anti-tobacco legislation (Law No. 4207 on the Prevention and Control of Harms of Tobacco Products) aims to ensure a "tobacco-free" life for current and future generations. However, there are observations of violations in the hospitality sector.

Assessing the feasibility, acceptability, and preliminary efficacy of the 'TraumaRelief' app for PTSD symptom management in Turkey: Study protocol for a pilot randomized controlled trial.

Unlabelled: The rate of exposure to traumatic events is high globally, and post-traumatic stress disorder (PTSD) is one of the most serious consequences. It was reported that approximately 14 million people were affected by earthquakes in Turkey in February 2023. Cognitive Behavioral Therapy (CBT) is a therapeutic approach to treating PTSD and has a proven efficacy.

Thiol-Disulfide Homeostasis in Noise-Induced Hearing Loss in Rats.

Background: This study was designed to assess if thiol-disulfide homeostasis could be used as diagnostic biomarker in noise-induced hearing loss (NIHL) in a laboratory animal model.

Methods: The study was carried out with a total of 28 female albino rats in 4 groups: group 1 (control group) included rats that were not exposed to noise or any study treatment; in group 2, following noise exposure, rats received 2 mg of dexamethasone per kilogram of body weight via the intramuscular route for 5 days; in Group 3, rats were exposed to noise and received a saline solution for 5 days, in a volume (0.15 cc) matched to that of dexamethasone administered in group 2; and in group 4, rats were exposed to noise, and blood samples were collected during the early phase to assess thiol-disulfide homeostasis without administering any treatment.