Molecular events in gastric carcinogenesis.

Gastric cancer represents an important problem for the public health, being one of the main causes of mortality. At present, it represents the second cause of mortality due to cancer, after the bronchopulmonary cancer in men and the fourth cause of mortality in women. Important progresses have been made in the last couple of years in determining the neoplastic etiopathogenesis, but it cannot be affirmed that the genetic mutations chain, which leads to the appearance of the malignant cell, has been fully understood.

Cause and effect: the linkage between the health information seeking behavior and the online environment--a review.

Today, health care consumers are taking more control over their health care problems, investing more time in finding and getting information as well as looking for proper methods in order to investigate more closely the health care information received from their physicians. Unfortunately, in health care consumers' views, the trustworthiness of health authorities and institutions has declined in the last years. So, consumers have found a new solution to their health problems, that is, the Internet.

Traumatic cardiac arrest in the emergency department - Overview upon primary causes.

Rationale: Trauma is the leading cause of death for patients aged less than 40 years. Trauma patients with cardiac arrest have low survival rates, the resuscitation being often considered futile and consumptive of medical and human resources.

Objective: The aim of this study is to describe the main characteristics in cases of patients critically traumatized, who were admitted in our emergency department.

An Utstein style based on a reporting system of the emergency department's cardiopulmonary resuscitation in an emergency hospital in Romania.

Rationale: Different Utstein based reporting systems are used for research purpose in resuscitative medicine worldwide and resuscitation attempts data are available from different countries. In Romania, the only data available has been from the previous work in the Emergency Department of "Sf. Pantelimon" Emergency Hospital, since 2006.

Intraoperative cholangiography still a current investigation.

Laparoscopic cholecystectomy is the standard treatment for patients requiring gallbladder removal. Although the advantages of the laparoscopic technique are widely accepted, the introduction of this technique has doubled the rate of iatrogenic lesions of extrahepatic bile ducts. Research methods for biliary tree also evolved, but intraoperative cholangiography, the traditional exploring method used for the biliary tree in classic cholecystectomy remains a valuable investigation in the laparoscopic technique.

Hepatitis C treatment & management.

Combination therapy with pegylated interferon alfa (PEG-IFN alfa) and the nucleoside analogue ribavirin is the current standard of care in patients infected with hepatitis C virus (HCV). Patients with HCV genotype 1 have a much less favorable response to therapy and are treated for 12 months, compared with patients infected with genotypes 2 and 3, in whom a 6-month course of therapy is sufficient. If viremia is present after 6 months, additional therapy has a negligible benefit, and treatment should be stopped in all patients regardless of the viral genotype.

Translating clinical research of Molecular Biology into a personalized, multidisciplinary approach of colorectal cancer patients.

Although multimodal treatment has brought important benefit, there is still great heterogeneity regarding the indication and response to chemotherapy in Stage II and III, and individual variations related to both overall survival and toxicity of new therapies in metastatic disease or tumor relapse. Recent research in molecular biology led to the development of a large scale of genetic biomarkers, but their clinical use is not concordant with the high expectations. The Aim of this review is to identify and discuss the molecular markers with proven clinical applicability as prognostic and/or predictive factors in CRC and also to establish a feasible algorithm of molecular testing, as routine practice, in the personalized, multidisciplinary approach of colorectal cancer patients in our country.