102 results match your criteria: ""Carol Davila" Central Military Emergency Hospital[Affiliation]"

With the development of 3D bioprinting and the creation of innovative biocompatible materials, several new approaches have brought advantages to patients and surgical teams. Increasingly more bone defects are now treated using 3D-bioprinted prostheses and implementing new solutions relies on the ability of engineers and medical teams to identify methods of anchoring 3D-printed prostheses and to reveal the potential influence of bioactive materials on surrounding tissues. In this paper, we described why limb salvage surgery based on 3D bioprinting is a reliable and effective alternative to amputations, and why this approach is considered the new standard in modern medicine.

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Purpose: The purpose of the present scoping review is to identify sources of heterogeneity in reporting domains that have the potential to improve surgical decision-making in reverse shoulder arthroplasty associated with glenoid bone grafting.

Methods: A scoping review was conducted according to the JBI and PRISMA ScR guidelines. Articles covering glenoid bone grafting at the time of reverse shoulder replacement, published between 2012 and 2022 in MEDLINE, Scopus, Epistemonikos, Web of Science, and Cochrane Database of Systematic Reviews, were searched.

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Thrombotic events during pregnancy are burdened by an increased risk of morbidity and mortality, despite innovations in their diagnosis and treatment. Given their multifactorial etiology, it is important to understand all the pathophysiological mechanisms but especially to achieve correct and timely diagnosis. Pulmonary embolism (PE) during pregnancy represents a rare event, with an incidence of 1 per 1000 pregnancies, but it is also one of the leading causes of death during pregnancy.

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Despite the growing popularity of training with a controlled form of vascular occlusion, known as blood flow restriction (BFR) training, in the rehabilitation of orthopedic patients and sports medicine, there remains ample space for understanding the basis of its mechanism. The pilot study assessed the effect of BFR during a low-load resistance training unit on knee flexor muscle fatigue, intending to decide whether a larger trial is needed and feasible. : The study used a prospective, randomized, parallel, double-blind, placebo-controlled design.

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Current Diagnostic and Therapeutic Challenges in Superficial Venous Thrombosis.

Medicina (Kaunas)

September 2024

Dr. Carol Davila University Central Military Emergency Hospital, "Carol Davila" University of Medicine and Pharmacy, Calea Plevnei 134, 010825 Bucharest, Romania.

Article Synopsis
  • * Risk factors for SVT include varicose veins, but other underlying issues like cancers or blood disorders may be present, especially in non-varicose veins.
  • * Diagnosis often requires duplex ultrasound (DUS) to determine the clot's characteristics, and treatment usually focuses on medical management, including anticoagulation and symptom relief, with more invasive approaches reserved for severe cases.
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  • - Somatostatin is a peptide with multifaceted roles as a neurotransmitter and endocrine regulator, primarily exerting inhibitory effects in various tissues, despite its low physiological concentrations.
  • - It binds to specific receptors called somatostatin receptors (SSTRs), which differ in tissue distribution and can be altered in conditions like tumors, making them useful as cancer biomarkers and for prognostic insights.
  • - The review discusses the five SSTRs, their therapeutic potentials for multiple conditions, including tumors and acromegaly, as well as the potential use of somatostatin antagonists in medical settings.
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  • * There is a noted but poorly defined connection between GD and cutaneous keratinocyte carcinomas, specifically non-melanoma skin cancers (NMSCs), with very few studies highlighting this relationship between 1983 and 2024.
  • * GD has been misdiagnosed as various NMSCs, and understanding this connection could provide insights into its underlying mechanisms, possibly reclassifying GD as a unique syndrome.
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Capsaicin, the most prominent pungent compound of chilli peppers, has been used in traditional medicine systems for centuries; it already has a number of established clinical and industrial applications. Capsaicin is known to act through the TRPV1 receptor, which exists in various tissues; capsaicin is hepatically metabolised, having a half-life correlated with the method of application. Research on various applications of capsaicin in different formulations is still ongoing.

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Obesity is an important condition affecting the quality of life of numerous patients and increasing their associated risk for multiple diseases, including tumors and immune-mediated disorders. Inflammation appears to play a major role in the development of obesity and represents a central point for the activity of cellular and humoral components in the adipose tissue. Macrophages play a key role as the main cellular component of the adipose tissue regulating the chronic inflammation and modulating the secretion and differentiation of various pro- and anti-inflammatory cytokines.

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Oral squamous cell carcinoma (OSCC), the most common type of head and neck cancer, remains a highly challenging cancer to treat, largely due to the late diagnosis in advanced stages of the disease, which occurs in more than half of cases [...

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Chronic inflammation is a constant phenomenon which accompanies the heart failure pathophysiology. In all phenotypes of heart failure, irrespective of the ejection fraction, there is a permanent low-grade activation and synthesis of proinflammatory cytokines. Many classes of anti-remodelling medication used in the treatment of chronic heart failure have been postulated to have an anti-inflammatory effect.

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Purpose: This study aims to assess the anatomical possibilities of the jugular bulb (JB).

Methods: Fifty archived CBCT scans were analyzed.

Results: The average distance between the internal acoustic canal (IAC) and the JB was 7.

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: The upper posterior teeth are typically regarded as being exclusively inferior to the maxillary sinus (MS). The expansion of the nasal fossa above the maxillary alveolar base (MAB) needs better investigation. The hypothesis was raised that the MAB in the upper premolar region, which is usually addressed by surgeons for the elevation of the antral floor, is not exclusively beneath the MS.

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Article Synopsis
  • Rheumatoid arthritis (RA) increases the risk of osteoporosis, with treatment type and certain vitamin levels affecting bone health.
  • A study compared the effects of biological (bDMARDs) and conventional synthetic (csDMARDs) treatments on trabecular bone scores (TBS) in 64 RA patients, finding both types improved TBS and bone mineral density (BMD) after one year.
  • The results were particularly positive for patients treated with the anti-TNF drug Adalimumab, and factors like high homocysteine and low vitamin D negatively impacted bone scores, highlighting the importance of managing these levels for RA patients.
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Introduction: Oropharyngeal cancer requires a comprehensive evaluation of treatment options, including surgery, radiation therapy, and chemotherapy. It is crucial to customize these treatments based on the stage of the tumor and the overall health of the patient, enabling personalized or combined approaches. Transoral surgical techniques have regained popularity due to the advancements and limitations of non-surgical strategies.

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The incidence of microbial infections in orthopedic prosthetic surgeries is a perennial problem that increases morbidity and mortality, representing one of the major complications of such medical interventions. The emergence of novel technologies, especially 3D printing, represents a promising avenue of development for reducing the risk of such eventualities. There are already a host of biomaterials, suitable for 3D printing, that are being tested for antimicrobial properties when they are coated with bioactive compounds, such as antibiotics, or combined with hydrogels with antimicrobial and antioxidant properties, such as chitosan and metal nanoparticles, among others.

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The management of the long head of the biceps tendon (LHBT) during shoulder arthroscopy has been a subject of controversy for many years, with evolving discussions and trends. Despite long-standing debate, the nature of the surgical indication regarding how to treat concomitent LHBT injuries has undergone changes in recent years. It now extends beyond the timing of tenotomy to encompass considerations of alternative methods for preserving the LHBT, along with an ongoing exploration of how it can be effectively utilized in reconstructive shoulder surgery.

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Cannabinoids have incited scientific interest in different conditions, including malignancy, due to increased exposure to cannabis. Furthermore, cannabinoids are increasingly used to alleviate cancer-related symptoms. This review paper aims to clarify the recent findings on the relationship between cannabinoids and oral cancer, focusing on the molecular mechanisms that could link cannabinoids with oral cancer pathogenesis.

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Along with the rapid and extensive advancements in the 3D printing field, a diverse range of uses for 3D printing have appeared in the spectrum of medical applications. Vat photopolymerization (VPP) stands out as one of the most extensively researched methods of 3D printing, with its main advantages being a high printing speed and the ability to produce high-resolution structures. A major challenge in using VPP 3D-printed materials in medicine is the general incompatibility of standard VPP resin mixtures with the requirements of biocompatibility and biofunctionality.

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Monitoring disease activity in inflammatory bowel disease (IBD) is challenging since clinical manifestations do not represent reliable surrogates for an accurate reflection of the inflammatory burden. Endoscopic remission had been the most significant endpoint target in the last years; nevertheless, a remarkable proportion of patients continue to relapse despite a normal-appearing mucosa, highlighting that endoscopy may underestimate the true extent of the disease. A subtle hint of the importance that histology plays in the long-term course of the disease has been endorsed by the STRIDE-II consensus, which recommends considering histologic healing for ulcerative colitis (UC), even though it is not stated to be a compulsory formal target.

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Chronic heart failure is a terminal point of a vast majority of cardiac or extracardiac causes affecting around 1-2% of the global population and more than 10% of the people above the age of 65. Inflammation is persistently associated with chronic diseases, contributing in many cases to the progression of disease. Even in a low inflammatory state, past studies raised the question of whether inflammation is a constant condition, or if it is, rather, triggered in different amounts, according to the phenotype of heart failure.

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Background: Routine anticoagulation therapy in acute pancreatitis (AP) is not recommended by the guidelines in the field, although it is frequently used in clinical practice.

Objectives: We aimed to analyze the efficacy and safety of adding anticoagulants therapy to AP management.

Methods: The systematic search was performed in three databases on the 14th of October 2022 without restrictions.

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Influence of exposure to climate-related hazards in the phenotypic expression of primary Sjögren's syndrome.

Clin Exp Rheumatol

December 2023

Department of Autoimmune Diseases, ICMiD, Hospital Clínic, Barcelona, and Department of Medicine, University of Barcelona, Spain.

Article Synopsis
  • - The study investigates how environmental factors, specifically climate-related natural hazards, may affect the diagnosis and symptoms of Sjögren's syndrome across different countries, examining aspects like epidemiological profiles and sicca symptoms.
  • - Researchers analyzed data from 16,042 patients in 23 countries, determining that those in countries severely impacted by climate hazards (like extreme precipitation and flooding) were often diagnosed with Sjögren's syndrome earlier and exhibited varying symptom frequencies.
  • - Findings revealed statistically significant patterns, indicating lower occurrences of dry eyes and mouth in patients from countries facing specific climate threats, while showing that increased climate-related risks correlated with higher disease activity scores (ESSDAI).
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Objectives: To analyse how the potential exposure to air pollutants can influence the key components at the time of diagnosis of Sjögren's phenotype (epidemiological profile, sicca symptoms, and systemic disease).

Methods: For the present study, the following variables were selected for harmonization and refinement: age, sex, country, fulfilment of 2002/2016 criteria items, dry eyes, dry mouth, and overall ESSDAI score. Air pollution indexes per country were defined according to the OECD (1990-2021), including emission data of nitrogen and sulphur oxides (NO/SO), particulate matter (PM2.

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