Shark chondroitin sulfate gold nanoparticles: A biocompatible apoptotic agent for osteosarcoma.

Osteosarcoma is a highly aggressive tumor that originates in the bone and often infiltrates nearby bone cells. It is the most prevalent type of primary bone cancer among the various bone malignancies. Traditional cancer treatment methods such as surgery, chemotherapy, immunotherapy, and radiotherapy have had restricted success.

Analysis of Dry Needling Combined with an Exercise Program in the Treatment of Knee Osteoarthritis: A Randomized Clinical Trial.

Therapeutic exercise is recommended for people with knee osteoarthritis (OA), although it could be complemented with other treatments such as dry needling (DN). The purpose of this study was to evaluate and compare the resulting data on pain, functionality, strength and range of motion in subjects with knee osteoarthritis after being treated with a specific therapeutic physical exercise program alone or in combination with the DN technique in the popliteus muscle. : A total of 33 participants were randomly assigned to two groups: the dry needling plus therapeutic physical exercise group ( = 15) and the therapeutic physical exercise alone group ( = 18).

Benefits of Complementary Therapies During Pregnancy, Childbirth and Postpartum Period: A Systematic Review.

Background/objectives: The current trend in maternal health is to foster more natural and less medicalized therapies, with increasing interest in complementary therapies. This study has analyzed the benefits of complementary therapies during pregnancy, delivery and the postpartum period.

Methods: A paired systematic review was carried out (PROSPERO: CRD42024543981).

Prevalence of Urinary Incontinence in Female Professional Soccer Players by Category and Specific Position: A Comparative Study with a Control Group.

Background/objectives: Urinary incontinence (UI) significantly impacts quality of life, with varying prevalence in women depending on factors such as age, childbirth, and type of sport practiced. This study compared the prevalence, types, and severity of urinary incontinence (UI) between professional female soccer players and sedentary students, analyzing its relation to playing position and competitive level.

Methods: A descriptive, observational, and analytical cross-sectional study was conducted, assessing the prevalence, severity, and types of UI among 235 nulliparous professional female soccer players (experimental group, EG) and 252 sedentary female students (control group, CG).

Technological Innovations to Support Family Caregivers: A Scoping Review.

Introduction: Population aging increases the risk of dependency among older adults, which in turn necessitates care, primarily provided by family caregivers. This situation leads to physical and emotional strain on these caregivers. New technologies, such as tele-education, digital platforms, or mobile applications, can offer an accessible and equitable alternative for caregiver training and self-care support.

Influence of Perceived Maternal Self-Efficacy on Exclusive Breastfeeding Initiation and Consolidation: A Systematic Review.

Background/objectives: Different international organizations recommend exclusive breastfeeding during the neonate's first six months of life; however, figures of around 38% are reported at the global level. One of the reasons for early abandonment is the mothers' perception of supplying insufficient milk to their newborns. The objective of this research is to assess how mothers' perceived level of self-efficacy during breastfeeding affects their ability to breastfeed and the rates of exclusive breastfeeding up to six months postpartum.

The Effects of a 12-Week Training Multicomponent Exercise Program on Landing Mechanics in Recreational Athletes.

Background/objectives: This study investigated the impacts of a 12-week training program on kinetic parameters during landings in non-professional recreational athletes.

Methods: Fifty-seven non-elite recreational athletes performed three unilateral-landing trials from a 30 cm high structure on a force platform. The following outcome measures were analyzed: the ground reaction forces at initial ground contact (PF1) and the highest value (PF2), impulse (change in the moment of force during landing), stabilization time, and ankle and knee accelerations.

Impact of Frozen Storage on Sensory, Physicochemical, and Volatile Compounds Parameters of Different Extra Virgin Olive Oils.

Storage is important for virgin olive oil, a product obtained only during the harvest period, which requires a year-round storage until its best-before date. Low temperatures slow undesirable reactions, though this method is not widely applied. The objective of this paper is to assess the impact of frozen storage on the volatile composition and sensory properties of virgin olive oils.

Development of three-layer microneedle system for controlled and sustained release of Levonorgestrel: A pioneering approach to long-term contraceptive delivery.

The increasing prevalence of unintended pregnancies, a persistent issue affecting public health and hindering progress towards the Sustainable Development Goals (SDGs), highlights the critical need for innovative contraceptive approaches. While current methods, including hormonal contraceptives such as levonorgestrel (LNG), offer potential solutions, challenges like limited access and inconsistent use persist. This study introduces a new approach with the development of a three-layer microneedle (TIMN) containing LNG designed to provide extended contraceptive efficacy.

Plant transfer factors of naturally occurring radioactive decay series radionuclides, Be, and Cs in a semi-arid climate.

Arid and semi-arid climates give rise to drought stress in plants, implying an increased uptake of radionuclides through both leaves and roots. This study was carried out in the Tabernas Desert (Almería, Spain), classified as an arid climate. Seventeen plants were analyzed, collected from four areas of the study site.

Relationship between donor source, pre-transplant measurable residual disease, and outcome after allografting for adults with acute myeloid leukemia.

Lack of HLA-matched related/unrelated donor remains a barrier to allogeneic hematopoietic cell transplantation (HCT) for adult acute myeloid leukemia (AML), with ongoing uncertainty about optimal donor type if more than one alternative donor is available. To assess the relationship between donor type, pre-HCT measurable residual disease (MRD), and post-HCT outcomes, we retrospectively analyzed 1265 myelodysplastic neoplasm (MDS)/AML and AML patients allografted in first or second remission with an HLA-matched sibling (MSD) or unrelated donor (MUD), HLA-mismatched unrelated donor (MMD), an HLA-haploidentical donor, or umbilical cord blood (UCB) at a single institution. Relapse risk was non-significantly higher after HLA-haploidentical and lower after UCB HCT.

Investigation of Sn Promoter on Ni/CeO Catalysts for Enhanced Acetylene Semihydrogenation to Ethylene.

Ethylene, as an important chemical raw material, could be produced through the coal-based acetylene hydrogenation route. Nickel-based catalysts demonstrate significant activity in the semihydrogenation reaction of acetylene, but they encounter challenges related to catalyst deactivation and overhydrogenation. Herein, the effect of Sn promoter on Ni/CeO catalysts has been comprehensively explored for acetylene semihydrogenation.

Empty nose syndrome: new insights from a CFD approach.

Objectives: Empty Nose Syndrome (ENS) is a debilitating condition which usually arises after aggressive turbinate reduction. However, objective tests to help in the diagnosis of this condition are lacking. Accurate diagnosis of ENS patients is critical for effective diagnosis and treatment.

Protective factors and mental health in couples who expect a child in confinement.

Objective: Adverse situations can affect the mental health and support of pregnant women and their partners, such as the COVID-19 pandemic and the resulting confinement periods. The main objective of this study was to evaluate the protective factors in the mental health of pregnant women and their partners, as well as the interrelationships of these factors, in an adverse situation, through the assessment of resilience, perceived support, anxiety, depression and stress.

Methods: The sample consisted of 38 women with no pregnancy risk and 25 partners evaluated between gestation weeks 24 and 31.

High-throughput phenotyping using hyperspectral indicators supports the genetic dissection of yield in durum wheat grown under heat and drought stress.

High-throughput phenotyping (HTP) provides new opportunities for efficiently dissecting the genetic basis of drought-adaptive traits, which is essential in current wheat breeding programs. The combined use of HTP and genome-wide association (GWAS) approaches has been useful in the assessment of complex traits such as yield, under field stress conditions including heat and drought. The aim of this study was to identify molecular markers associated with yield (YLD) in elite durum wheat that could be explained using hyperspectral indices (HSIs) under drought field conditions in Mediterranean environments in Southern Spain.

Modulatory effects of CNNM4 on protein- l -isoaspartyl- O -methyltransferase repair function during alcohol-induced hepatic damage.

Background And Aims: Alcohol-associated liver disease (ALD) is a leading cause of liver-related mortality worldwide, with limited treatment options beyond abstinence and liver transplantation. Chronic alcohol consumption has been linked to magnesium (Mg 2+ ) deficiency, which can influence liver disease progression. The mechanisms underlying Mg 2+ homeostasis dysregulation in ALD remain elusive.

Endotyping in Chronic Rhinosinusitis-An EAACI Task Force Report.

Chronic rhinosinusitis (CRS) is a clinical syndrome defined by typical sinonasal symptoms persisting for at least 12 weeks. CRS is divided into two distinct phenotypes, CRS with nasal polyps (CRSwNP) and without (CRSsNP). The aim of the review is to provide an update on the current knowledge in CRS endotypes.

Impact of the deep squat on articular knee joint structures, friend or enemy? A scoping review.

Background: The squat exercise has been shown to improve athletic performance. However, the use of the deep squat has been questioned due to claims that it may cause knee joint injuries. Therefore, the purpose of this scoping review was to synthesize existing literature concerning the impact of deep squats on knee osteoarticular health in resistance-trained individuals.

Acute Responses to Different Velocity-Loss Thresholds During Squat Training With and Without Blood-Flow Restriction.

Purpose: To compare the acute effects on mechanical, metabolic, neuromuscular, and muscle contractile responses to different velocity-loss (VL) thresholds (20% and 40%) under distinct blood-flow conditions (free [FF] vs restricted [BFR]) in full squat (SQ).

Methods: Twenty strength-trained men performed 4 SQ protocols with 60% 1-repetition maximum that differed in the VL within the set and in the blood-flow condition (FF20: FF with 20% VL; FF40: FF with 40% VL; BFR20: BFR with 20% VL; and BFR40: BFR with 40% VL). The level of BFR was 50% of the arterial occlusion pressure.

Healthcare resource utilization and related cost of non-HIV comorbidity management in people with HIV in a Spanish cohort from 2007-2016.

Objective: To estimate the cost and healthcare resource utilization (HRU) associated with the prevalence of comorbidities in people living with HIV (PLWH) in a Spanish cohort over ten years.

Methods: A cohort study carried out at the HIV outpatient clinic of the University Hospital Virgen del Rocío based on data collected during 2007-2016. PLWH with at least one follow-up visit were included.