4,406 results match your criteria: "" Soroka University Medical Center[Affiliation]"

For patients undergoing abdominal surgery, postoperative pulmonary complications (PPCs) are a major source of morbidity and mortality. The use of point-of-care ultrasonography (POCUS), and specifically POCUS of the lungs, has seen many advancements in recent years. We hypothesize that perioperative lung ultrasonography can be used as a predictor for PPCs.

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Corneal cross-linking.

Prog Retin Eye Res

January 2025

ELZA Institute, Webereistrasse 2, CH-8953, Dietikon, Switzerland; Laboratory for Ocular Cell Biology, University of Zurich, Winterthurerstrasse 190, CH-8057, Zurich, Switzerland; Faculty of Medicine, University of Geneva, Rue Michel-Servet 1, CH-1206, Geneva, Switzerland. Electronic address:

First introduced over 20 years ago as a treatment for progressive keratoconus, the original "Dresden" corneal cross-linking (CXL) protocol involved riboflavin saturation of the stroma, followed by 30 min of 3 mW/cm-intensity ultraviolet-A (UV-A) irradiation. This procedure generates reactive oxygen species (ROS) that cross-link stromal molecules, thereby stiffening the cornea and counteracting the ectasia-induced weakening. Due to their large size, riboflavin molecules cannot readily pass through the corneal epithelial cell tight junctions; thus, epithelial debridement was performed.

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Extensive research has been published on atopic dermatitis (AD), a prevalent skin condition among pediatricians. To assess the pediatric representation in the most cited literature on AD, using bibliometric analysis. Web of Science citation indexing database was used to identify publications with "atopic" and "dermatitis" or "eczema" in their title.

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A novel tool to predict lymph node metastasis in patients with prostate cancer based on clinical and Ga-PSMA PET/CT parameters.

Can Urol Assoc J

December 2024

Department of Urology, Tel-Aviv Sourasky Medical Center, Sackler School of Medicine, Tel-Aviv University, Tel Aviv, Israel.

Introduction: We sought to develop a model that predicts lymph node invasion (LNI) in patients with intermediate- and high-risk prostate cancer incorporating preoperative clinical and Ga-prostate-specific membrane antigen positron emission tomography/computed tomography (PSMA PET/CT) parameters.

Methods: A cohort of 413 consecutive patients diagnosed with prostate cancer who underwent Ga- PSMA PET/CT prior to radical prostatectomy from 2015-2020 was used to develop and validate the model. The cohort was split into a learning (70%) and a validation group (30%).

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Children with specific psychophysiological profiles may be more strongly affected by adverse environmental experiences. Guided by a biopsychosocial perspective, we examined whether infant respiratory sinus arrhythmia (RSA), an index of parasympathetic functioning, moderates the associations between paternal postpartum depression (PPD) symptoms and infants' observed empathy-related responses. Participants were 142 families with infants (51% female) assessed at two time points.

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Treatment With mTOR Inhibitors as Primary Immunosuppression After Combined Heart and Kidney Transplantation.

J Card Fail

December 2024

Department of Cardiovascular Diseases and Health Sciences Research and the William J. von Liebig Center for Transplantation and Clinical Regeneration, Mayo Clinic, Rochester, MN, USA. Electronic address:

Aims: Sirolimus (SRL) mitigates cardiac allograft vasculopathy (CAV) progression and confers renal protection after heart transplantation (HT). However, its safety and efficacy in patients undergoing combined heart and kidney transplantation (HKT) are unclear. This study aimed to investigate the impact of conversion from calcineurin inhibitors (CNI) to SRL on CAV progression, renal function, and outcomes in HKT compared to isolated HT.

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Introduction: Despite the declining public health emergency status, COVID-19 still poses significant risks, especially for immunocompromised individuals. We aimed to evaluate the effectiveness of tixagevimab-cilgavimab (T-C) prophylaxis in preventing severe COVID-19 in patients with hematologic malignancies (HM) treated with anti-CD20 therapy during the early Omicron variant phase of the pandemic.

Methods: The European Society of Clinical Microbiology and Infectious Diseases Study Group for Respiratory Viruses (ESGREV) conducted a multicenter retrospective cohort study involving 15 centers from 5 countries.

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Treatment effects of elexacaftor/tezacaftor/ivacaftor on people with cystic fibrosis heterozygous for 3849+10kbC->T and a class I variant.

J Cyst Fibros

December 2024

Pulmonology Institute and Adult CF Center, Rabin Medical Center, Petach Tikva, Israel; School of Medicine, Faculty of Medical and Health Sciences, Tel Aviv University, Tel Aviv, Israel.

Background: The splice variant 3849+10kbC->T (c.3717+12191C>T) (3849 variant) is a residual function CFTR variant, characterized by insertion of an in-frame stop codon into most CFTR transcripts. Both ivacaftor (Iva) and tezacaftor/ivacaftor (Tez/Iva) have been approved for people with CF (pwCF) carrying the 3849 variant.

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We describe a rare case of metastatic prostate carcinoma to the heel. Bone scintigraphy revealed high uptake simulating fractures. Standard PSMA PET/CT was negative.

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Onasemnogene abeparvovec (OA) is a novel gene replacement therapy for patients with spinal muscular atrophy (SMA). This study provides real-world respiratory data for pediatric SMA patients receiving OA who were assessed before and one year after treatment in a multicenter cohort study conducted from 2019 to 2021. Twenty-five OA-treated SMA patients (23 with type 1 and 2 with type 2; median age at treatment 6.

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Article Synopsis
  • Alopecia Areata (AA) is an autoimmune disease that influences white blood cell activity, but previous research hasn't linked blood ratios to the condition's severity.
  • A study comparing various blood cell ratios in over 147,000 AA patients and 141,000 healthy controls found higher Neutrophils-to-Lymphocytes Ratio (NLR) and Eosinophils-to-Lymphocytes Ratio (ELR) in AA patients, especially in those with moderate-severe cases.
  • The findings suggest that these blood ratios could be useful for predicting and managing AA, contrary to earlier studies, making them a cost-effective tool for disease assessment.
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Risk of pneumonia among children with cleft palate before and after palatoplasty: a population-based study.

Eur J Pediatr

December 2024

Faculty of Health Sciences, Department of Plastic Surgery, Soroka University Medical Center, Ben-Gurion University of the Negev, Be'er Sheva, Israel.

Unlabelled: Pneumonia remains the primary cause of mortality among children under age 5. Cleft palate (CP) poses various challenges including velopharyngeal disfunction, potentially increasing rates of pneumonia. However, clinical evidence linking pneumonia to defect is lacking.

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Introduction: This prospective, observational study investigated the impact of patient/anesthesiologist interactions and socioeconomic factors on administering intravenous analgesics and anxiolytics during elective Cesarean delivery under spinal anesthesia. The study explored the role of emotional experiences and psychosocial characteristics on intraoperative administration of intravenous adjuncts.

Methods: The study included 502 patient/anesthesiologist dyads from two hospitals in Israel.

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The association between female sex and depression following traumatic brain injury: A systematic review and meta-analysis.

Neurosci Biobehav Rev

January 2025

Department of Anesthesiology and Perioperative Medicine, Mayo Clinic, Jacksonville, FL, USA. Electronic address:

While women tend to experience more severe psychiatric and neurobehavioral symptoms following traumatic brain injury (TBI), the connection between sex and post-TBI depression remains poorly understood. To explore the potential association between sex and post-TBI depression, we conducted a systematic review and meta-analysis, including studies with participants who had no prior diagnosis of depression. Thirteen studies met the criteria for inclusion, collectively investigating a cohort of 449,471 individuals with TBI.

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Objective: Patients with chronic idiopathic intracranial hypertension (IIH) commonly experience a high level of disability and low satisfaction with medical treatment. We aim to evaluate long-term functional improvement and patient satisfaction in IIH patients with similar symptoms by comparing venous sinus stenting (VSS) to standard medical therapy.

Methods: We conducted a cross-sectional questionnaire study of 111 IIH patients, comparing 37 adult female patients who underwent venous sinus stenting with 74 patients treated medically.

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Background: The respiratory syncytial virus (RSV) is a leading cause of lower respiratory tract infections in infants and is associated with an increased risk of asthma development. Palivizumab, an RSV prophylactic, reduces RSV-related hospitalizations in high-risk infants, but its impact on long-term asthma outcomes remains unclear. This study compares asthma-related healthcare utilization in preschool children born prematurely between those who received Palivizumab (the Prophylaxis (+) group) and those who did not (the Prophylaxis (-) group).

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The impact of obstetrical anal sphincter injuries on the interpregnancy interval and pregnancy complications of subsequent delivery: A retrospective study.

Int J Gynaecol Obstet

November 2024

Department of Obstetrics and Gynecology, Soroka University Medical Center (SUMC), Faculty of Health Sciences, Ben-Gurion University of the Negev, Beer-Sheva, Israel.

Article Synopsis
  • The study aimed to assess the interpregnancy interval (IPI) of women who suffered obstetric anal sphincter injuries (OASIS) during childbirth and compare outcomes based on IPI length.
  • Researchers analyzed data from women who had subsequent pregnancies after OASIS alongside a control group without such injuries, using medical records from 2015 to 2019.
  • Results showed no significant difference in mean IPI between the groups, but women with OASIS had higher rates of repeat perineal tears, episiotomies, and cesarean sections in their next deliveries, indicating ongoing risks despite not delaying future pregnancies.
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Article Synopsis
  • - The study investigates the link between non-arteritic anterior ischemic optic neuropathy (NAION) and hypoperfusion states, considering cardiovascular risk factors like hypertension and diabetes.
  • - Researchers analyzed medical records of 1,374 NAION patients and 5,496 matched controls, finding a 6.5-fold increased risk of NAION associated with hypoperfusion events in the month leading to diagnosis.
  • - Key findings highlight cardiac dysfunction and hypovolemia as major risk factors for NAION, with cerebrovascular accidents also posing a significant independent risk.
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A substantial body of literature has been published on acne vulgaris (AV) in the past five decades. Bibliometric analysis (BA) is a scientific, statistical evaluation review of published articles, providing a quantitative assessment of past research. The Web of Science (webOS) citation indexing database was used on 11 June 2023 to identify the top 100 cited articles on AV.

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Association between metabolic and bariatric surgery and malignancy: a systematic review, meta-analysis, trends, and conclusions.

Surg Obes Relat Dis

October 2024

Department of Surgery A, Soroka University Medical Center, Ben-Gurion University of the Negev, Beer-Sheva, Israel; The Department of Public Health, Faculty of Health Sciences, Ben-Gurion University of the Negev, Beer-Sheva, Israel. Electronic address:

Background: Conflicting studies have investigated the association between obesity, metabolic and bariatric surgery (MBS), and cancer.

Objectives: Our study aimed at elucidating the trends in cancer incidence that are related to obesity and weight loss managed through MBSs, like Colo-rectal, breast, uterine, and esophageal cancer.

Setting: We conducted a search using PubMed, Embase, and the Cochrane Library electronic databases through May 2020.

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