Potential plant extinctions with the loss of the Pleistocene mammoth steppe.

During the Pleistocene-Holocene transition, the dominant mammoth steppe ecosystem across northern Eurasia vanished, in parallel with megafauna extinctions. However, plant extinction patterns are rarely detected due to lack of identifiable fossil records. Here, we introduce a method for detection of plant taxa loss at regional (extirpation) to potentially global scale (extinction) and their causes, as determined from ancient plant DNA metabarcoding in sediment cores (sedaDNA) from lakes in Siberia and Alaska over the past 28,000 years.

Inflammaging Markers in the Extremely Cold Climate: A Case Study of Yakutian Population.

Yakutia is one of the coldest permanently inhabited regions in the world, characterized by a subarctic climate with average January temperatures near -40 °C and the minimum below -60 °C. Recently, we demonstrated accelerated epigenetic aging of the Yakutian population in comparison to their Central Russian counterparts, residing in a considerably milder climate. In this paper, we analyzed these cohorts from the inflammaging perspective and addressed two hypotheses: a mismatch in the immunological profiles and accelerated inflammatory aging in Yakuts.

Amine antioxidants in water, ice, sediment and soil from the Songhua Wetland, Northeast China: Occurrence and fate.

Amine antioxidants (ANs) are emerging organic pollutants that are widely used in industrial products. The extensive use of ANs has polluted the environments. At present, there is no report on the pollution situation of ANs in wetland environment.

[Salivary minerals and caries experience among adolescents in Syktyvkar, Komi Republic].

Objective: To study the associations between salivary minerals concentrations and caries experience among adolescents in the conditions of one of the industrial centers of the Far North.

Material And Methods: In total, 146 adolescents aged 15-17 years took part in a cross-sectional study in Syktyvkar, Komi Republic. Caries experience was assessed as DMFT index and its components.

Machine Learning Prediction of the Corrosion Rate of Zinc-Based Alloys Containing Copper, Lithium, Magnesium, and Silver.

Implementation of machine learning (ML) techniques in materials science often requires large data sets. However, a proper choice of features and regression methods allows the construction of accurate ML models able to work with a relatively small data set. In this work, an extensive, although still limited, experimental data set of corrosion-related properties of Zn-based alloys used in biomedicine was created.

Protein-Variant-Phenotype Study of NBAS Using AlphaFold in the Aspect of SOPH Syndrome.

NBAS gene variants cause phenotypically distinct and nonoverlapping conditions, SOPH syndrome and ILFS2. NBAS is a so-called "moonlighting" protein responsible for retrograde membrane trafficking and nonsense-mediated decay. However, its three-dimensional model and the nature of its possible interactions with other proteins have remained elusive.

To Stay or to Leave: The Role of School, Family, and Prosocial Goals in Migration Intentions of Russian High School Students.

Background: Migration intentions are extremely common among modern youth practically all around the globe. They do not always result in actual migration, but they should definitely be considered as an important indicator for the society, since the potential loss of the most valuable human resources entails long-term consequences for the development of a country or region. This study aims to examine the system of psychological factors that determine the desire of young people to stay in their region.

Using Thin Ultra-High-Molecular-Weight Polyethylene Coatings to Reduce Friction in Frost-Resistant Rubbers.

Frost-resistant rubbers retain their highly elastic properties over a wide temperature range. They are used in various friction units (e.g.

Genotype-phenotype analysis of hearing function in patients with DFNB1A caused by the c.-23+1G>A splice site variant of the GJB2 gene (Cx26).

The audiological features of hearing loss (HL) in patients with autosomal recessive deafness type 1A (DFNB1A) caused by splice site variants of the GJB2 gene are less studied than those of patients with other variants of this gene. In this study, we present the audiological features of DFNB1A in a large cohort of 134 patients with the homozygous splice site variant c.-23+1G>A and 34 patients with other biallelic GJB2 genotypes (n = 168 patients with DFNB1A).

Screening and quantification of pesticides in wetland water, ice, sediment and soil: Occurrence, transport and risk assessment.

Current researches on pesticides in wetlands are limited in terms of screening and quantification of many types of pesticides. Understanding the spatial and temporal dynamics, distribution patterns, and environmental risks of pesticides in multiple media is important for wetland ecological conservation. In this study, 222 pesticides were determined in multimedia samples collected simultaneously from the Songhua Wetland during four seasons.

Associations of the AVPR1A RS1 Microsatellite Locus with the Level of Hormones of the Anterior Pituitary Gland and Personality Traits.

The arginine vasopressin receptor gene (AVPR1A) is one of the genes affecting mental processes. The aim of this study was to search for associations of microsatellite locus RS1, which is related to the AVPR1A expression level, with the level of hormones of the anterior pituitary gland and personality traits. The study sample included Yakut men aged 18-26 years (n = 121).

Metabolomics combined with physiology reveal how white clover (Trifolium repens L.) respond to 6PPD stress.

As a ubiquitous tire antioxidant, N-(1,3-Dimethyl-butyl)-N'-phenyl-p-phenylene- diamine (6PPD) exists widely in various environmental media and has been detected at high levels in the environment. However, the effects of 6PPD on plants are still poorly understood. In this study, a hydroponic experiment was carried out to investigate the response of white clover (Trifolium repens L.

Density Functional Theory-Based Indicators to Estimate the Corrosion Potentials of Zinc Alloys in Chlorine-, Oxidizing-, and Sulfur-Harsh Environments.

Nowadays, biodegradable metals and alloys, as well as their corrosion behavior, are of particular interest. The corrosion process of metals and alloys under various harsh conditions can be studied via the investigation of corrosion atom adsorption on metal surfaces. This can be performed using density functional theory-based simulations.

Variational inequality for a Timoshenko plate contacting at the boundary with an inclined obstacle.

A class of variational inequalities describing the equilibrium of elastic Timoshenko plates whose boundary is in contact with the side surface of an inclined obstacle is considered. At the plate boundary, mixed conditions of Dirichlet type and a non-penetration condition of inequality type are imposed on displacements in the mid-plane. The novelty consists of modelling oblique interaction with the inclined obstacle which takes into account shear deformation and rotation of transverse cross-sections in the plate.

[The population morbidity with diseases of ear and mastoid and accessibility of otorhinolaryngological care].

The article analyses level and dynamics of morbidity of diseases of ear and mastoid in the Sakha Republic (Yakutia) in 2020-2021 and availability of otorhinolaryngological care. The methods of comparative statistics and mathematical analysis were applied to analyze official data provided by the Yakut Republic Medical Information and Analytical Center, the specialized Department of Otorhinolaryngology, the Republic Hospital № 2 - Center for Emergency Medical Care and the Federal State Statistics Service of Russia. The study established increasing trend of increasing morbidity of these diseases in both the adult and child population.

Three-dimensional genome architecture persists in a 52,000-year-old woolly mammoth skin sample.

Analyses of ancient DNA typically involve sequencing the surviving short oligonucleotides and aligning to genome assemblies from related, modern species. Here, we report that skin from a female woolly mammoth (†Mammuthus primigenius) that died 52,000 years ago retained its ancient genome architecture. We use PaleoHi-C to map chromatin contacts and assemble its genome, yielding 28 chromosome-length scaffolds.

High prevalence of m.1555A > G in patients with hearing loss in the Baikal Lake region of Russia as a result of founder effect.

Mitochondrial forms account approximately 1-2% of all nonsyndromic cases of hearing loss (HL). One of the most common causative variants of mtDNA is the m.1555A > G variant of the MT-RNR1 gene (OMIM 561000).

A Case of Adult-Onset Still's Disease With Positive Antinuclear Antibodies and Positive Antineutrophil Cytoplasmic Antibodies.

Adult-onset Still's disease (AOSD) is a rare autoinflammatory disease characterized by nonspecific symptoms such as fever, maculopapular rash, and arthralgias. The exact etiology and pathogenesis remain unclear despite advancements in medical science. Diagnosis is typically established using the Yamaguchi criteria, which include a negative antinuclear antibody (ANA) test as one of the minor criteria.

IFN-I Score and Rare Genetic Variants in Children with Systemic Lupus Erythematosus.

Interferon I (IFN I) signaling hyperactivation is considered one of the most important pathogenetic mechanisms in systemic lupus erythematosus (SLE). Early manifestation and more severe SLE courses in children suggest a stronger genetic influence in childhood-onset SLE (cSLE). To evaluate IFN-I score and SLE-associated genetic variants in cSLE.

High Frequency of Ancestral Haplotype A of Fatty Acid Desaturase Genes in the Yakut Population.

The purpose of this study was to study the correlation of the body weight of Yakuts with the variability of polymorphisms rs174537, rs174546 and rs3834458 of the region to identify the connection of certain genotypes with obesity. For genotyping, classical methods of PCR-RFLP analysis were used. A sample of 446 DNA samples from Yakut volunteers without chronic diseases (143 women and 303 men) was studied.