4,343 results match your criteria: "" Alma Mater Studiorum-University of Bologna[Affiliation]"

Cellular motility is essential for making and maintaining multicellular organisms throughout their lifespan. Migrating cells can move either individually or collectively by a crawling movement that links the cytoskeletal activity to the adhesion surface. In vitro stimulation by electric fields can be achieved by direct, capacitive or inductive coupled setups.

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  • The study assesses the effectiveness of the BD BACTEC™ MGIT™ system for detecting non-tuberculous mycobacteria (NTM) in sanitary water, focusing on samples from heater-cooler units and haemodialysis instruments over a five-year period.
  • A total of 1,369 water samples from HCUs and 747 from dialysis machines were tested, with 261 and 20 cultures yielding NTM, respectively, verified through advanced techniques.
  • Results show that the MGIT system is not only reliable and reproducible for clinical applications but also effective for environmental testing of NTM, detecting concentrations as low as 4 CFU/mL.
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Genetic aspects of major blood metabolites in the Italian Simmental cattle population.

J Dairy Sci

February 2025

Department of Agronomy, Food, Natural resources, Animals and Environment, University of Padova, 35020 Legnaro, Italy.

Article Synopsis
  • The Simmental breed is less prone to ketosis and has better disease resistance than Holsteins, making it a resilient option in dairy farming.
  • A study analyzed blood metrics like BHB, NEFA, and urea from 3,549 cows to determine their genetic correlations with milk production and health traits.
  • Findings indicated that higher breeding values for BHB are linked to better metabolic health in offspring, suggesting that monitoring genetic variability in these traits could reduce disease risks in future generations.
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It is currently impossible to perform an evidence-based risk assessment for medication use during breastfeeding. The ConcePTION project aims to provide information about the use of medicines during lactation. The study aimed to develop and characterize an in vitro model of the blood-milk barrier to determine the extent of the milk transfer of xenobiotics, relying on either on human mammary epithelial cells (hMECs) or immortalized cell lines derived from breast tissue.

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Foot and ankle disorders are a very common diseases, represent a risk factor for falls in older people, and are associated with difficulty performing activities of daily living. With an increasing demand for cost-effective and high-quality clinical services, wearable technology can be strategic in extending our reach to patients with foot and ankle disorders. In recent years, wearable sensors have been increasingly utilized to assess the clinical outcomes of surgery, rehabilitation, and orthotic treatments.

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A Cloud Infrastructure for Health Monitoring in Emergency Response Scenarios.

Sensors (Basel)

October 2024

Experimental Pathology Research Group, Department of Clinical and Molecular Sciences, Università Politecnica delle Marche, 60121 Ancona, Italy.

Article Synopsis
  • Wearable devices and modern sensor technologies are transforming healthcare by enabling continuous vital sign monitoring, which is crucial for emergency management and worker safety.
  • Traditional infrastructure struggles with the data and computational demands of monitoring applications, but Cloud computing offers an effective solution with resilience and scalability.
  • A study monitored 900 paramedics over 12 months using a Cloud-based system for real-time tracking of vital signs, resulting in improved safety and efficiency in emergency response operations.
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Total Body Positron Emission Tomography/Computed Tomography: Current Status in Oncology.

Semin Nucl Med

January 2025

Nuclear Medicine, IRCCS Azienda Ospedaliero-Universitaria di Bologna, Bologna, Italy; Nuclear Medicine, Alma Mater Studiorum University of Bologna, Bologna, Italy.

Positron Emission Tomography (PET) is a crucial imaging modality in oncology, providing functional insights by detecting metabolic activity in tissues. Total-body (TB) PET and large field-of-view PET have emerged as advanced techniques, offering whole-body imaging in a single acquisition. TB PET enables simultaneous imaging from head to toe, providing comprehensive information on tumor distribution, metastasis, and treatment response.

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Sperm metabolism consists of a sophisticated network of biochemical reactions and varies between species, resulting in different metabolic strategies for ATP production to maintain sperm functionality. ATP can be produced through glycolysis or in the mitochondria by oxidative phosphorylation (OXPHOS). Since OXPHOS is the predominant metabolic pathway in horses spermatozoa, various assessments of mitochondrial activity are used to evaluate fertility, utilizing techniques such as fluorescent probes analysed via microscopy or flow cytometry, and polarographic electrode assays to measure current flow in response to an applied voltage.

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In recent years, the prevalence of chronic kidney disease (CKD) has significantly increased, with an estimated 843.6 million individuals affected in 2017 [1]. This rise is closely linked to the growing incidence of risk factors such as diabetes mellitus and obesity.

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Parameter analysis in stereoelectroencephalography-guided radiofrequency thermocoagulation: A common basis for objective comparison between protocols.

Epilepsy Res

December 2024

IRCCS Istituto delle Scienze Neurologiche di Bologna, Full Member of the European Reference Network EpiCARE, Bologna 40139, Italy. Electronic address:

Objective: Stereoelectroencephalography-guided radiofrequency thermocoagulation (SEEG-guided RF-TC) is an invasive procedure based on stereotactic lesioning of cortical targets in the brain using bipolar current through electrode contacts within the SEEG implant. To date, several RF-TC protocols have been described in the literature; however, a consensus has yet to be reached. This work aims to analyze the electrical parameters during RF-TC processes, offering a method to objectively describe and compare different SEEG-guided RF-TC protocols.

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  • * Current guidelines emphasize that lower levels of low-density lipoprotein cholesterol (LDL-C) are better, advocating for early and aggressive treatment, including a variety of effective medications beyond just statins.
  • * The International Lipid Expert Panel (ILEP) has published guidelines for optimizing LLT in post-ACS patients, highlighting the need for combination therapies and personalized care to improve adherence and treatment outcomes among high-risk individuals.
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Key Clinical Message: Obesity results in higher risk of some cancers while obesity stigma affect patient's quality of care. In this case report, a 46 kg ovary mass was misdiagnosed as severe obesity. Obesity stigma awareness and a sustained effort from healthcare professionals are required to deliver adequate patient care to patients with obesity.

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This case series aimed to assess the clinical outcomes of oncologic patients rehabilitated with a zygomatic implant-supported prosthesis. Ten oncologic patients who underwent upper jaw resections due to cancer were enrolled in the study. Zygomatic implants were utilized for rehabilitation according to specified inclusion criteria.

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New strategies for the treatment of hyperkalemia.

Eur J Intern Med

November 2024

Hypertension and Cardiovascular Disease Research Center, Medical and Surgical Sciences Department, Alma Mater Studiorum University of Bologna, Italy; Cardiovascular Medicine Unit, Heart-Chest-Vascular Department, IRCCS Azienda Ospedaliero-Universitaria di Bologna, Italy.

Article Synopsis
  • RAAS inhibitors and MRAs are crucial for treating patients with cardiovascular diseases, especially those with hypertension, diabetes, chronic kidney disease, and heart failure, as they effectively lower health risks.
  • However, up to 50% of these patients experience hyperkalaemia, leading to frequent treatment adjustments that may worsen their health outcomes.
  • Recent guidelines emphasize new strategies for managing hyperkalaemia to allow continuous use of RAASi and MRAs, aiming to improve patient management and reduce mortality and morbidity risks.
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  • The study explores late-onset immune-related adverse events (irAEs) from immune checkpoint inhibitors (ICIs), emphasizing the limited evidence available to date.
  • It analyzes data from 6006 individual case safety reports (ICSRs) collected in VigiBase, identifying the prevalence and types of late-onset irAEs, finding thyroiditis and pneumonitis to be among the most common.
  • The results indicate a strong association between late-onset irAEs and factors like ICI combination therapy, multiple irAEs, cutaneous irAEs, and the specific use of ICIs in melanoma patients.
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Campylobacteriosis is an infectious zoonotic disease caused by the genus Campylobacter. The disease is transmitted from animals to humans predominantly through the consumption of contaminated food and water. However, the lack of information on the status of Campylobacter makes it difficult to quantify the role of camel meat in the dissemination of the pathogen.

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  • - Fasting-mimicking diets (FMD), specifically a low-salt version (LS-FMD), were tested in rats with kidney damage and were found to restore normal kidney function and structure by inducing a nephrogenic gene program.
  • - LS-FMD activated pathways that promote cell reprogramming in the kidney, specifically targeting podocytes, which play a critical role in kidney health.
  • - A pilot study in patients with chronic kidney disease showed that FMD cycles improved kidney function and reduced protein levels in urine, indicating potential for further research in treating progressive kidney diseases.
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Background: Measuring psychological constructs in children presents unique challenges, as careful consideration of children's cognitive and socioemotional development is needed. The Trait Emotional Intelligence Questionnaire-Child Form (TEIQue-CF) was developed within the theoretical underpinnings of trait Emotional Intelligence theory and is predicated on primary aged children. This review aims to systematize the scientific literature on the TEIQue-CF, its corresponding short form, the TEIQue-CSF and the translated versions of these tools to identify the key outcomes predicted by these forms in children aged 8-13 years.

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We have warmly welcomed the opportunity to propose the Special Issue titled "Novel Diagnosis and Therapeutics Approaches in Retina Diseases", and numerous authors have decided to submit their works to it [...

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