713 results match your criteria: ""Ştefan cel Mare" University[Affiliation]"

Tropical cyclones (TCs) are one of the major natural hazards to island and coastal communities and ecosystems. However, isotopic compositions of TC-derived precipitation (P) in surface water (SW) and groundwater (GW) reservoirs are still lacking. We tested the three main assumptions of the isotope storm "spike" hypothesis (sudden spikes in isotopic ratios).

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Balancing increasing demand for wood products while also maintaining forest biodiversity is a paramount challenge. Europe's Biodiversity and Forest Strategies for 2030 attempt to address this challenge. Together, they call for strict protection of 10% of land area, including all primary and old growth forests, increasing use of ecological forestry, and less reliance on monocultural plantations.

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Interest in the transition of care for cystic fibrosis (CF) patients has grown significantly over time, driven by advancements in treatment that have extended life expectancy. As more CF patients survive into adulthood, the need for structured transition strategies has become a priority for healthcare systems worldwide. Transition programs for CF differ globally, reflecting varying resources and healthcare systems.

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Background: Occupational stress and burnout in the medical field are common factors that can have a negative impact on the quality of clinical care. In the Romanian healthcare environment, there exists important financial difficulties contributing additionally to stress in this study, we aimed to investigate if resilience and emotional intelligence would prove to be protective factors against stress.

Methods: In our cross-sectional study, we investigated 189 medical professionals, using convenience sampling, from July 2022 to September 2022 in two university centers.

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Unlocking the Potential of Pyrrole: Recent Advances in New Pyrrole-Containing Compounds with Antibacterial Potential.

Int J Mol Sci

November 2024

Scientific Center for Drug Research, Pharmaceutical and Toxicological Chemistry Department, "Nicolae Testemitanu" State University of Medicine and Pharmacy, 165 Bd. Stefan Cel Mare si Sfant, MD-2004 Chisinau, Moldova.

Nitrogen heterocycles are valuable structural elements in the molecules of antibacterial drugs approved and used to treat bacterial infections. Pyrrole is a five-atom heterocycle found in many natural compounds with biological activity, including antibacterial activity. Numerous compounds are being develop based on the pyrrole heterocycle as new potential antibacterial drugs.

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Environmental Indicator Plants in Mountain Forests: A Review.

Plants (Basel)

November 2024

Department of Chemistry, Physics and Environment, Faculty of Sciences and Environmental, Dunarea de Jos University Galati, Domneasca Street No. 47, 800008 Galati, Romania.

Plant indicators are important in studies related to the environment, and mountain forests are rich in such plants. We conducted this study using the Web of Science Core Collection tools and the VOSviewer program combined with a classic review, based on the specialty literature. The topic of indicator plants in mountain forests has been (the first article published in a prestigious journal dates back to 1980) and remains relevant (after 2015, between 40 and 60 articles were published annually), with the total number of publications found being 665 articles and 22 review articles.

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Article Synopsis
  • The study investigates how nutritional knowledge, attitudes, and practices affect diet quality in women of reproductive age, highlighting the role of socioeconomic factors and information sources.
  • Data was collected from 465 women through an anonymous online questionnaire, assessing their diet quality using the FIGO diet quality score, while also examining the influence of healthcare advice and personal knowledge.
  • Results showed that better food choices, higher knowledge levels, and healthcare advice all significantly improved diet quality, with knowledge acting as a key mediator for the effectiveness of healthcare guidance.
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Hydrogels are interesting materials as delivery systems of various therapeutic agents, mainly due to the water-swollen network and the localized and sustained drug release. Herein, single-component starch-based hydrogels with enhanced degradation rates were produced by applying a facile synthesis and proposed for a novel delivery system of therapeutic molecules. Starch was oxidized with sodium periodate in water and mild conditions to generate aldehyde derivatives that, after a freeze-thaw procedure, were allowed to compact and stable hydrogels.

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Patients with COVID-19 suffering in the acute phase from both the sequelae of the disease and prolonged immobilization require a rehabilitation phase for functional recovery and a comprehensive functional evaluation. This study proposes using the 6-Minute Walk Test (6MWT) as a global functional assessment tool to quantify rehabilitation outcomes in post-COVID patients. Additionally, investigating the effect of High-Intensity Laser Therapy (HILT) on patients with musculoskeletal comorbidities was another key research question.

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Tuberculosis is the primary cause of death due to infection in the world. Identification of in sputum is a diagnostic test, which can be used in screening programs-especially in countries with a high incidence of tuberculosis-to identify and treat those persons with the highest risk of disseminating the infection. We previously developed an algorithm which is able to automatically detect mycobacteria on tissue; in particular, our algorithm identified acid-fast bacilli on tissue with 100% specificity, 95.

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The medial patellofemoral ligament (MPFL) is critical for patellar stability. This study investigates the efficacy of a one-year physical therapy rehabilitation program following MPFL reconstruction using Synthetic Graft (SG) and Quadriceps Tendon Autograft (QTA). Thirty-five patients aged 18-38 underwent MPFL reconstruction (20 SG, 15 QTA).

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Sodium Alginate-Starch Capsules for Enhanced Stability of Metformin in Simulated Gastrointestinal Fluids.

Biomimetics (Basel)

November 2024

The Department of Biological and Morphofunctional Sciences, College of Medicine and Biological Science, Stefan cel Mare University of Suceava, 720229 Suceava, Romania.

The use of biopolymers in pharmaceuticals is well established, particularly for encapsulating biologically active compounds due to their beneficial properties. Alginate, widely recognized for its excellent encapsulation abilities, is the most commonly used biopolymer, while starch, typically known as insoluble dietary fiber, also serves as an effective agent for trapping and protecting compounds during processing, storage, and gastrointestinal transit. Sodium alginate-starch capsules with varying compositions were analyzed to develop metformin hydrochloride (MET) containing capsules with adequate physicochemical properties.

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The key locations of freshwater input driving Atlantic Meridional Overturning Circulation (AMOC) slowdown and their climate responses remain inconclusive. Using a state-of-the-art global climate model, we conduct freshwater hosing experiments to reexamine AMOC sensitivity and its climate impacts. The Irminger basin emerges as the most effective region for additional freshwater fluxes, causing the greatest AMOC weakening.

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Rapeseeds (), cultivated widely as a source of oil, generate substantial by-products after oil extraction. Unfortunately, rapeseed meal is considered a waste product and as such is discharged into environment as compost or used as animal feed. However, this meal is rich in bioactive compounds (proteins, minerals, fibers and polyphenols), indicating its potential for the development of value-added products.

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Article Synopsis
  • * Conducted in Romanian maternity hospitals from 2015-2023, the study analyzed data from 104 patients with preeclampsia, revealing that 82.6% of those who had seizures suffered significant health complications.
  • * Key risk factors for maternal morbidity included advanced age, thrombotic disorders, obesity, and smoking, indicating the need for careful monitoring and intervention during pregnancy to potentially reduce these risks.
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A quality assessment and systematic review of clinical practice guidelines on hormone replacement therapy for menopause using the AGREE II instrument.

Eur J Obstet Gynecol Reprod Biol

December 2024

Mother and Child Department, "Iuliu Hațieganu" University of Medicine and Pharmacy, 8 Victor Babes Str, Cluj-Napoca 400347, Romania; 2(nd) Obstetrics and Gynaecology Clinical Section, Cluj County Emergency Clinical Hospital, 55-57 21(st) of December 1989 Bld, Cluj-Napoca 400124, Romania.

Clinical Practice Guidelines (CPGs) have an indispensable role in guiding the selection of treatments for menopause. Variations in guidelines can impact treatments and health outcomes. The aim of this study was to assess CPGs on hormone replacement therapy (HRT) for menopause, systematically reviewing their quality and compiling recommendations for HRT usage.

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Article Synopsis
  • This study investigates risk factors for all-cause mortality and major cardiovascular events in patients undergoing ambulatory blood pressure monitoring, which helps track blood pressure outside of clinical settings.! -
  • The research analyzed data from 1,291 patients, finding that survival rates improved with certain blood pressure patterns and age, while poorer outcomes were associated with smoking and specific blood pressure dips.! -
  • The study emphasizes the importance of diastolic blood pressure dipping and nighttime variability in predicting health outcomes, highlighting the need for personalized treatment approaches in hypertension management.!
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Drought events are increasingly impacting Europe. The study of past droughts helps disentangle the different factors that trigger hydrological drought, helping to forecast future drought severity. Here we identify the historical drought events of the twentieth and twenty-first centuries in geochemical records of a stalagmite from Caumont cave in Northern France and develop a mechanistic understanding of their root causes.

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Rationale: Sporadic cases of acute appendicitis (AA) in children with SARS-CoV-2 infection were still recorded at the end of COVID-19 pandemics. We consider that analyses of clinical courses and outcomes is useful to improve the clinical management of such cases in the setting of a general hospital.

Patient Concerns: Patient #1 was a 14-year-old girl who presented with nausea, right lower quadrant (RLQ) pain, myalgia, ad low-grade fever for 24 hours.

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Acetone Sensors Based on Al-Coated and Ni-Doped Copper Oxide Nanocrystalline Thin Films.

Sensors (Basel)

October 2024

Center for Nanotechnology and Nanosensors, Technical University of Moldova, 168 Stefan cel Mare Av., MD-2004 Chisinau, Moldova.

Acetone detection is of significant importance in various industries, from cosmetics to pharmaceuticals, bioengineering, and paints. Sensor manufacturing involves the use of different semiconductor materials as well as different metals for doping and functionalization, allowing them to achieve advanced or unique properties in different sensor applications. In the healthcare field, these sensors play a crucial role in the non-invasive diagnosis of various diseases, offering a potential way to monitor metabolic conditions by analyzing respiration.

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This study aimed to evaluate the changes in quality of life (QoL) over a 12-month period among opiate users in Romania, identifying factors that contribute to a worsening of their condition. By examining these dynamics, the research intended to inform targeted interventions and support mechanisms to mitigate the negative outcomes associated with opiate use. Conducted as a longitudinal cohort analysis, this study enrolled 74 participants diagnosed with opioid use disorders from multiple healthcare settings in Romania.

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Background: High-Intensity Laser (HIL) therapy, known for its biostimulatory effects on nerve cell growth and repair, shows promise for improving motor deficits caused by morphopathological changes. This research study aimed to comprehensively assess muscle strength changes through muscle testing, complemented by functional tests evaluating factors contributing to disability in patients with Lumbar Disc Herniation (LDH) and associated motor impairment, following a complex rehabilitation protocol incorporating HIL therapy.

Methods: A total of 133 individuals with LDH and motor deficits were divided into two groups.

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Autoimmune blistering diseases represent a group of chronic severe, disabling, and potentially fatal disorders of the skin and/or mucous membranes, primarily mediated by pathogenic auto-antibodies. Despite their rarity, these diseases are associated with significant morbidity and mortality and profound negative impact on the patient's quality of life and impose a considerable economic burden. Rituximab, an anti-CD-20 monoclonal antibody, represents the first line of therapy for pemphigus, regardless of severity and a valuable off-label therapeutic alternative for subepidermal autoimmune blistering diseases as it ensures high rates of rapid, long-lasting complete remission.

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The fruit, juice, and pomace of black chokeberry () are a rich source of phenolic compounds and can be used to obtain enriched dairy products. Chokeberry fruit, due to its astringent taste, is less favorable or even unacceptable to consumers and is usually processed into juice, resulting in large quantities of pomace, which is often discarded as waste. The aim of this study is to valorize chokeberry fruit, juice, and pomace by incorporating them in different percentages (1, 2, and 3%) into yogurt as functional ingredients.

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This study provides new insights into the oviposition strategy of (Linnaeus, 1758) (Lepidoptera, Lasiocampidae), an endangered species of moth found in semi-natural habitats within agricultural landscapes. Protected under various European directives and listed as Data Deficient by the IUCN, inhabits warmer regions of the Western Palearctic. Despite noted geographic variations in its ecological preferences, few studies have statistically significant data on its ecology.

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