Xdemvy (lotilaner)
Research Synopsis
- Lotilaner, marketed as Xdemvy (Credelio™), is a new oral medication for flea and tick control in dogs and cats, demonstrating high efficacy in killing ectoparasites.
- Research indicates that lotilaner achieves over 99% efficacy in killing fleas within 8 hours post-treatment, with sustained protection for at least 84 days in dogs.
- In various studies conducted across Europe and the USA, lotilaner was found to outperform other treatments like fipronil in both speed of kill and prolonged effectiveness against fleas and ticks.
- The flavored chewable tablets are well-tolerated by dogs and cats, with studies showing minimal side effects and high acceptance among pets.
- Lotilaner has been shown to alleviate symptoms of flea allergy dermatitis in dogs, providing significant clinical improvements alongside its antiparasitic effects.
- Comprehensive safety evaluations revealed that treatment with lotilaner did not adversely affect body weight, feeding behavior, or overall health during prolonged use.
- Pharmacokinetic studies highlighted that food enhances the absorption of lotilaner, leading to quicker peak concentrations and extended efficacy in both dogs and cats.
- Lotilaner also shows efficacy against common tick species, with studies reporting over 99% effectiveness against existing ticks, significantly reducing the risk of pathogen transmission.
- The product is part of the isoxazoline class, functioning as a potent antagonist to invertebrate GABA channels, which is unique compared to other insecticides, suggesting broad applications in parasitic control.
- Overall, lotilaner (Xdemvy) has proven to be a safe, effective, and practical option for pet owners managing flea and tick infestations across various environments.
Xdemvy (lotilaner)
Assessment of the speed of flea kill of lotilaner (Credelio™) throughout the month following oral administration to dogs.
London, UK
2 hours ago
1 Received
- Lotilaner is a new oral insecticide and acaricide for dogs that effectively kills fleas, with a half-life of 30 days allowing prolonged efficacy.
- Four studies were conducted to assess how quickly and effectively lotilaner can kill fleas after a single treatment, showing it achieves over 99% efficacy within the first 8 hours and maintains high effectiveness for 35 days.
- The results suggest that regular monthly use of lotilaner can help disrupt flea populations and mitigate health risks associated with flea infestations in dogs, with no observed adverse effects.
$100 - $150
Hourly Rate
Assessment of the onset of lotilaner (Credelio™) speed of kill of fleas on dogs.
London, UK
2 hours ago
1 Received
- Lotilaner (Credelio™) is a new oral treatment for flea infestations in dogs, developed to work quickly and effectively against ectoparasites.
- In a study involving Beagles, dogs were grouped and treated with lotilaner or left untreated, with flea counts measured at various intervals following treatment.
- The results showed that while there was no significant reduction in flea counts at 30 minutes and 1 hour, a 64% reduction was observed at 2 hours, increasing to 99.6% effectiveness at 8 hours, with no adverse effects reported.
$100 - $150
Hourly Rate
A randomised, blinded, controlled field study to assess the efficacy and safety of lotilaner tablets (Credelio™) in controlling fleas in client-owned dogs in European countries.
London, UK
2 hours ago
1 Received
- Lotilaner is a new oral medication for dogs that effectively kills fleas and ticks, showing high efficacy (over 99%) for at least 84 days after treatment in a field study conducted across Europe.
- In the study, 128 households received lotilaner and 64 received fipronil, with results showing lotilaner was consistently more effective at eliminating fleas than fipronil, with at least 90% of treated dogs flea-free.
- Lotilaner chewable tablets were found to be tasty and well-tolerated by dogs, successfully alleviating symptoms of flea allergy dermatitis, including itching.
$100 - $150
Hourly Rate
A randomized, controlled field study to assess the efficacy and safety of lotilaner flavored chewable tablets (Credelio™) in eliminating fleas in client-owned dogs in the USA.
London, UK
2 hours ago
1 Received
- A study tested a new flea and tick treatment for dogs, lotilaner (Credelio™), showing it provided rapid and sustained knockdown of fleas for at least three months.
- The trial involved 111 dogs receiving lotilaner and 50 receiving afoxolaner (Nexgard®), with significant reductions in flea counts seen within a month for both treatments.
- Lotilaner had a 100% flea-free rate by Day 90, while both treatments were well-accepted by dogs and effectively managed symptoms of flea allergy dermatitis.
$100 - $150
Hourly Rate
Lotilaner - a novel systemic tick and flea control product for dogs.
London, UK
2 hours ago
1 Received
$100 - $150
Hourly Rate
A randomized, controlled study to assess the efficacy and safety of lotilaner (Credelio™) in controlling ticks in client-owned dogs in Europe.
London, UK
2 hours ago
1 Received
- Lotilaner chewable tablets (Credelio™) for dogs show rapid tick-killing action and sustained efficacy for at least 35 days.
- A study conducted in Europe involved 19 clinics, comparing lotilaner's efficacy with another product (FSM) in treating ticks on client-owned dogs.
- Results indicated that lotilaner provided significantly greater tick count reductions (over 99% efficacy by Day 56) compared to FSM, and both treatments were well-tolerated by dogs.
$100 - $150
Hourly Rate
Laboratory evaluations of the immediate and sustained efficacy of lotilaner (Credelio™) against four common species of ticks affecting dogs in North America.
London, UK
2 hours ago
1 Received
- Lotilaner is a treatment for dogs that effectively controls infestations of common ticks, reducing the risk of pathogen transmission.
- Eight studies were conducted to test its efficacy against different tick species, including Dermacentor variabilis and Rhipicephalus sanguineus, using a standardized treatment protocol.
- The results showed that lotilaner achieved 100% effectiveness against existing tick infestations, with very few minor side effects reported.
$100 - $150
Hourly Rate
Two randomized, controlled studies to assess the efficacy and safety of lotilaner (Credelio™) in preventing Dermacentor reticulatus transmission of Babesia canis to dogs.
London, UK
2 hours ago
1 Received
- Dogs are at risk of Babesia spp. infections, leading to a study on the effectiveness of lotilaner (Credelio™) against Babesia canis.
- In two studies, dogs were divided into treatment and control groups, with some receiving lotilaner and others receiving no treatment while being exposed to infected ticks.
- The results showed that all control dogs became infected with B. canis, while all lotilaner-treated dogs remained free of the infection, demonstrating the treatment's 100% efficacy.
$100 - $150
Hourly Rate
The intravenous and oral pharmacokinetics of lotilaner in dogs.
London, UK
2 hours ago
1 Received
- Lotilaner is an oral treatment for fleas and ticks in dogs, available as flavored chewable tablets called Credelio™, and is a member of the isoxazoline class.
- A pharmacokinetic study involving 26 beagle dogs evaluated the absorption and effects of food on the drug's bioavailability after various methods of administration (oral and intravenous).
- Key findings show that when given orally to fed dogs, lotilaner is quickly absorbed with a peak concentration in about 2 hours and has a long half-life of approximately 30.7 days, with food significantly enhancing its absorption without affecting bioavailability under different feeding conditions.
$100 - $150
Hourly Rate
Laboratory evaluations of the immediate and sustained effectiveness of lotilaner (Credelio™) against three common species of ticks affecting dogs in Europe.
London, UK
2 hours ago
1 Received
- Lotilaner (Credelio™) is an effective new treatment for controlling tick infestations in dogs, showing rapid efficacy and sustained results against prevalent tick species in Europe.
- Two studies involving Beagle dogs demonstrated that optimized doses of lotilaner led to a significant reduction in live ticks, with 100% effectiveness reported in most assessments.
- The findings indicate lotilaner as a reliable option for tick control, with no live ticks found on treated dogs shortly after treatment and minimal re-infestation rates over time.
$100 - $150
Hourly Rate
Efficacy of lotilaner (Credelio™), a novel oral isoxazoline against naturally occurring mange mite infestations in dogs caused by Demodex spp.
London, UK
2 hours ago
1 Received
- - The study evaluated the effectiveness of lotilaner (Credelio™) in treating dogs with generalized demodicosis caused by Demodex spp. mites.
- - A group of 10 dogs received oral lotilaner treatment at specified intervals, resulting in a more than 99.9% reduction in mite counts and complete elimination of live mites by Day 84 post-treatment.
- - All treated dogs showed significant clinical improvement and no adverse effects, with noticeable hair regrowth beginning 6 weeks after treatment started.
$100 - $150
Hourly Rate
The novel isoxazoline ectoparasiticide lotilaner (Credelio™): a non-competitive antagonist specific to invertebrates γ-aminobutyric acid-gated chloride channels (GABACls).
London, UK
2 hours ago
1 Received
- Isoxazolines, including lotilaner (Credelio™), are a new class of drugs that effectively inhibit GABA-gated chloride channels, making them potent against various ectoparasites like fleas and ticks.
- The study successfully identified and functionally expressed GABACls from different species, revealing that lotilaner is a strong non-competitive antagonist that does not exhibit cross-resistance with other insecticides like dieldrin or fipronil.
- Results confirm that isoxazolines are specifically effective against invertebrate GABACls, showing potential for broad applications in controlling parasites while demonstrating no adverse effects on canines.
$100 - $150
Hourly Rate
Safety evaluation of lotilaner in dogs after oral administration as flavoured chewable tablets (Credelio™).
London, UK
2 hours ago
1 Received
- The study investigated the safety of lotilaner, a new flea and tick medication for dogs, administered monthly to healthy Beagle puppies over 8 months at varying doses.
- A group of 32 puppies was divided into treatment groups receiving different doses, while a control group went untreated, and various health assessments were conducted to monitor safety.
- Results showed that lotilaner was well-tolerated, with no adverse effects on body weight, food consumption, or clinical examinations in the treated dogs compared to controls.
$100 - $150
Hourly Rate
Laboratory evaluation of the speed of kill of lotilaner (Credelio™) against Ixodes ricinus ticks on dogs.
London, UK
2 hours ago
1 Received
- - Lotilaner, a new tick treatment for dogs, is highly effective, killing 98% of ticks for over a month after administering a chewable tablet.
- - In a study, dogs treated with lotilaner showed a 69.8% reduction in live tick counts within 4 hours and a near-total elimination (99.2%) at 8 hours post-treatment.
- - Lotilaner's efficacy remained strong over repeated infestations, with significant differences in tick counts observed compared to untreated dogs, and no adverse side effects reported.
$100 - $150
Hourly Rate
Laboratory evaluation of the efficacy and speed of kill of lotilaner (Credelio) against Ixodes ricinus ticks on cats.
London, UK
2 hours ago
1 Received
- Lotilaner, a chewable tablet approved for dogs and now also for cats (Credelio), offers a safe and effective way to control ticks in felines compared to topical treatments.
- Three key studies evaluated its effectiveness after a single oral dose of about 6 mg/kg against Ixodes ricinus ticks, measuring results at various intervals.
- Results showed over 99% efficacy in killing ticks within specified timeframes, with no significant adverse effects noted, confirming lotilaner's suitability as a parasiticide for cats.
$100 - $150
Hourly Rate
A randomized, controlled field study to assess the efficacy and safety of lotilaner (Credelio™) in controlling ticks in client-owned cats in Europe.
London, UK
2 hours ago
1 Received
- - A study was conducted across 20 clinics in Europe to evaluate the effectiveness and safety of lotilaner versus fipronil for treating tick infestations in cats, focusing on a minimum dosage of 6.0 mg/kg of lotilaner.
- - Results showed that lotilaner demonstrated a significantly higher efficacy (98.3-100%) in reducing tick counts compared to fipronil (89.6-99.6%), particularly on several assessment days, establishing lotilaner as a superior treatment option.
- - Both treatments were well tolerated by cats and successfully administered by owners throughout the study period, indicating practicality for use in real-world settings.
$100 - $150
Hourly Rate
Safety of lotilaner flavoured chewable tablets (Credelio) after oral administration in cats.
London, UK
2 hours ago
1 Received
- Lotilaner, a new isoxazoline drug, was tested for safety in healthy kittens (starting at 8 weeks old) through a study involving orally administered chewable tablets for 8 months at varying doses.
- Kittens were divided into groups receiving either the drug at 1× (26 mg/kg), 3× (78 mg/kg), or 5× (130 mg/kg) the maximum recommended dose, while a control group received no treatment.
- Results showed that all treated kittens had detectable levels of lotilaner with no significant negative effects on health, feeding, or clinical examinations, although some differences were noted in clinical pathology evaluations.
$100 - $150
Hourly Rate
A randomized, controlled field study to assess the efficacy and safety of lotilaner (Credelio™) in controlling fleas in client-owned cats in Europe.
London, UK
2 hours ago
1 Received
- Lotilaner is a new oral ectoparasiticide for cats, showing effective and prolonged flea control for at least one month, based on prior lab studies.
- A field study involving 121 households in Europe compared the efficacy of Lotilaner with a topical treatment (fipronil/(S)-methoprene) in controlling fleas and flea allergy dermatitis (FAD).
- Results indicated Lotilaner provided a significantly higher efficacy (97.2% on Day 14 and 98.1% on Day 28) compared to fipronil/(S)-methoprene (48.3% and 46.4% respectively), with at least 81% of Lotilaner-treated cats being
$100 - $150
Hourly Rate
Lotilaner - a novel formulation for cats provides systemic tick and flea control.
London, UK
2 hours ago
1 Received
$100 - $150
Hourly Rate
Pharmacokinetics of lotilaner following a single oral or intravenous administration in cats.
London, UK
2 hours ago
1 Received
- Credelio (lotilaner) is an oral treatment for flea and tick infestations in cats, available as flavored chewable tablets and developed to be highly effective.
- A pharmacokinetic study showed that when given orally, lotilaner is absorbed quickly in fed cats, achieving peak levels in about four hours and maintaining effectiveness for at least 33.6 days.
- The study confirmed that food enhances the absorption of lotilaner, leading to nearly 100% bioavailability, making it a reliable option for long-term parasite control in cats.
$100 - $150
Hourly Rate