Defencath (taurolidine, heparin)
Research Synopsis
Defencath (taurolidine, heparin)
Inhibition of peritoneal tumor cell growth and implantation in laparoscopic surgery in a rat model.
London, UK
2 hours ago
1 Received
- - The study investigates the impact of taurolidine and heparin on the growth of colon cancer cells, aiming to understand how to prevent tumor recurrence after laparoscopic surgery.
- - In laboratory tests, both taurolidine and a combination of taurolidine and heparin reduced cancer cell growth, whereas heparin alone had a minimal effect.
- - In a rat model, tumor weights significantly decreased when animals were treated with taurolidine and heparin together compared to controls, indicating that taurolidine is particularly effective against tumor growth.
$100 - $150
Hourly Rate
[Peritoneal instillation of taurolidine and heparin for preventing intraperitoneal tumor growth and trocar metastases in laparoscopic operations in the rat model].
London, UK
2 hours ago
1 Received
- * Results showed that while heparin had little impact on tumor growth, taurolidine significantly reduced tumor cell growth both in vitro and in vivo.
- * The combination of taurolidine and heparin further decreased tumor weight and metastases compared to controls, suggesting a potential strategy for preventing tumor implantation post-surgery.
$100 - $150
Hourly Rate
Influence of different gases and intraperitoneal instillation of antiadherent or cytotoxic agents on peritoneal tumor cell growth and implantation with laparoscopic surgery in a rat model.
London, UK
2 hours ago
1 Received
- A study was conducted to evaluate alternative gases and agents (taurolidine, heparin, povidone-iodine) for reducing tumor growth during laparoscopic surgery in rats, with significant tumor cells introduced.
- Results showed that taurolidine and taurolidine with heparin effectively reduced tumor weight across different gas environments (CO2, helium, xenon), while povidone-iodine was only beneficial in the CO2 group.
- The findings suggest that the use of xenon or the combination of xenon with povidone-iodine may actually increase tumor growth, highlighting the need for careful selection of surgical gases and agents in cancer patients.
$100 - $150
Hourly Rate
New therapeutic strategies to avoid intra- and extraperitoneal metastases during laparoscopy: results of a tumor model in the rat.
London, UK
2 hours ago
1 Received
- Therapeutic approaches to prevent cancer recurrence at port sites during laparoscopic surgery were explored for the first time, focusing on three agents: taurolidine, heparin, and povidone iodine.
- In vitro studies showed that tumor growth was reduced by taurolidine and combinations of the agents, with taurolidine also suppressing cytokine release stimulated by carbon dioxide.
- In vivo results indicated that while heparin and povidone iodine marginally reduced tumor weight, taurolidine and its combination with heparin led to the most significant decrease in tumor growth and metastases.
$100 - $150
Hourly Rate
Modulation of tumor-induced lethality after pneumoperitoneum in a mouse model.
London, UK
2 hours ago
1 Received
- A study investigated the impact of carbon dioxide pneumoperitoneum on survival in mice with ovarian carcinoma after laparoscopic surgery, finding it significantly reduced survival time compared to control groups without pneumoperitoneum.
- The research also examined the effectiveness of two chemotherapy treatments, mitoxantrone and taurolidine combined with heparin, concluding that pneumoperitoneum diminished mitoxantrone's survival benefits but allowed some positive impact of taurolidine/heparin on survival in that context.
- Ultimately, the study suggests that while pneumoperitoneum may promote tumor growth and reduce chemotherapy effectiveness, the combination of taurolidine/heparin could mitigate some of these adverse effects.
$100 - $150
Hourly Rate
Influence of intraperitoneal and systemic application of taurolidine and taurolidine/heparin during laparoscopy on intraperitoneal and subcutaneous tumour growth in rats.
London, UK
2 hours ago
1 Received
- Recent studies highlight the issue of portsite metastases after laparoscopic surgery for malignant tumors, with no established prevention methods currently available.
- Researchers conducted experiments on rats to test the effects of taurolidine and heparin on tumor growth after laparoscopic resection, using different administration methods (intraperitoneal and intravenous).
- Results showed that intraperitoneal administration of taurolidine significantly decreased tumor weight compared to controls, while no significant changes were observed in subcutaneous tumor growth; some reduction in trocar recurrences was noted with taurolidine treatment.
$100 - $150
Hourly Rate
Antimicrobial activity of a novel catheter lock solution.
London, UK
2 hours ago
1 Received
- Intravascular catheter-associated bloodstream infections lead to increased illness and hospital costs due to microbial colonization and biofilm formation, which are tough to treat with antibiotics.
- A study tested a new catheter lock solution with taurolidine and citrate, demonstrating that it significantly reduces the growth of various harmful bacteria and fungi in lab models compared to traditional heparin treatment.
- The taurolidine-citrate solution also effectively eradicated biofilms, showing greater reduction rates than heparin, indicating its potential as a strong preventive and treatment option for catheter-related infections.
$100 - $150
Hourly Rate
Stability and in vitro efficacy of antibiotic-heparin lock solutions potentially useful for treatment of central venous catheter-related sepsis.
London, UK
2 hours ago
1 Received
- The study aimed to evaluate the stability and effectiveness of antibiotic-heparin lock solutions in preventing and treating infections related to central venous catheters.
- Various antibiotics were tested individually and in combinations with heparin to determine their compatibility and efficacy against common infection-causing microorganisms.
- Results suggest that certain antibiotic-heparin combinations show promise for use in clinical settings, indicating the need for further clinical trials to assess their impact on catheter-related infections.
$100 - $150
Hourly Rate
Prophylaxis against dialysis catheter-related bacteremia with a novel antimicrobial lock solution.
London, UK
2 hours ago
1 Received
- Catheter-related bacteremia is a common issue for patients on hemodialysis, but can potentially be prevented by targeting catheter biofilms.
- An investigational catheter lock solution (CLS) containing taurolidine and citrate was tested in 20 hemodialysis patients, compared to 30 patients using heparin.
- Results showed that CLS significantly reduced bacteremia cases (94% survival vs. 47%) but required more thrombolytic treatments for maintaining catheter flow (32% patency vs. 76%).
$100 - $150
Hourly Rate
The influence of adhesion prophylactic substances and taurolidine/heparin on local recurrence and intraperitoneal tumor growth after laparoscopic-assisted bowel resection of colon carcinoma in a rat model.
London, UK
2 hours ago
1 Received
- - The study aimed to assess how different substances (Interceed/Intergel and taurolidine/heparin) affect tumor growth and recurrence after laparoscopic cecum surgery in a rat model with colon cancer.
- - Sixty BDIX rats were divided into four groups (three treatment groups and one control), with one treatment involving these substances and the control receiving saline. After four weeks, tumor growth and adhesion formation were measured post-euthanasia.
- - Results showed that taurolidine/heparin notably reduced the size and weight of tumors but did not affect local recurrence rates or adhesion formation, while Interceed and Intergel had no significant impact on tumor growth.
$100 - $150
Hourly Rate
Local and systemic chemotherapy with taurolidine and taurolidine/heparin in colon cancer-bearing rats undergoing laparotomy.
London, UK
2 hours ago
1 Received
- Experimental studies demonstrate that while various cytotoxic agents can reduce the growth of malignant tumors in the abdomen, there's no widely accepted method to prevent tumor recurrence.
- In a rat model, researchers injected colon adenocarcinoma cells and tested the effects of taurolidine and taurolidine combined with heparin on tumor growth through both local (intraperitoneal) and systemic (intravenous) applications.
- Results showed that intraperitoneal administration of taurolidine alone or in combination with heparin significantly reduced local tumor growth compared to a control group, while subcutaneous tumor growth and abdominal wound recurrences were similar across all treatment groups.
$100 - $150
Hourly Rate
Prevention of dialysis catheter-related sepsis with a citrate-taurolidine-containing lock solution.
London, UK
2 hours ago
1 Received
- - The study investigates the effectiveness of a catheter lock solution containing the antimicrobial taurolidine versus heparin in preventing catheter-related sepsis in patients undergoing haemodialysis.
- - Despite similar rates of catheter colonization and exit-site infections, the taurolidine group had no cases of catheter-related sepsis, while the heparin group experienced four cases.
- - The findings suggest that taurolidine is not only effective in reducing sepsis risk but also safe, lacking the side effects associated with other antimicrobial solutions.
$100 - $150
Hourly Rate
Irrigation of port sites: prevention of port site metastases?
London, UK
2 hours ago
1 Received
- Port site metastases may occur when tumor cells implant at trocar wounds during surgeries, leading researchers to investigate irrigation with cytotoxic agents as a preventive measure.
- The study involved WAG rats that received injections of tumor cells and were then irrigated with different solutions after surgery, including povidone-iodine, taurolidine and heparin, or sodium chloride, whereas control rats had no irrigation.
- Results showed no significant difference in tumor growth at trocar wounds between the various irrigation methods and the control group, indicating that irrigation did not provide any benefits or harms in this model.
$100 - $150
Hourly Rate
[Catheter lock solution--taurolock for prevention of catheter-related bacteremia in hemodialysis patients].
London, UK
2 hours ago
1 Received
- Bacteremia and thrombosis are serious complications associated with tunneled cuff central vein catheters used for hemodialysis, and bacterial biofilm is a leading cause of catheter-related infections.
- The study involved 13 chronic hemodialysis patients: 5 with a history of bacteremia (Group A) and 8 with new catheters (Group B), utilizing a catheter lock solution (TauroLock) to prevent infections.
- Results showed a significant decrease in infection rates, with Group A seeing a drop in bacteremia episodes and Group B reporting no infections at all, highlighting TauroLock’s effectiveness in enhancing patient care.
$100 - $150
Hourly Rate
Influence of intraperitoneal application of taurolidine/heparin on expression of adhesion molecules and colon cancer in rats undergoing laparoscopy.
London, UK
2 hours ago
1 Received
- - Recent studies indicate that taurolidine/heparin, when administered intraperitoneally after laparoscopy, can significantly reduce local tumor growth in rats, potentially due to their anti-adherent properties.
- - In the experiment, rats were treated with either taurolidine/heparin or saline after receiving colon cancer cells, with results showing a notable decrease in tumor weight and number in the taurolidine/heparin group, despite some adhesion molecule levels remaining unchanged.
- - The treatment resulted in a marked reduction of E-cadherin expression, raising questions about its role in tumor biology, highlighting the need for further research to clarify its significance in cancer development.
$100 - $150
Hourly Rate
Catheter lock solutions: it's time for a change.
London, UK
2 hours ago
1 Received
- The use of central vascular catheters (CVCs) in hemodialysis patients has increased, bringing risks of bloodstream infections and dialysis complications.
- Alternative locking solutions like trisodium citrate, citrate, and taurolidine are safer and more effective than heparin, which can encourage biofilm formation.
- High concentrations of citrate can help reduce clotting in catheters but require further research with larger groups to ensure safety and proper application by trained professionals.
$100 - $150
Hourly Rate
Instillation of taurolidine/heparin after laparotomy reduces intraperitoneal tumour growth in a colon cancer rat model.
London, UK
2 hours ago
1 Received
- The study aimed to see if rinsing the abdominal cavity with taurolidine/heparin during colon surgery could lower tumor growth and local recurrence in rats with colon cancer.
- 60 rats underwent surgery and received either taurolidine/heparin, Intergel, Interceed, or saline, after which their metastatic growth and adhesions were evaluated.
- Results showed that taurolidine/heparin significantly reduced both the number and weight of tumors in the abdominal cavity compared to the control group, suggesting it could be beneficial during colon cancer surgeries.
$100 - $150
Hourly Rate
Intra-abdominal use of taurolidine or heparin as alternative products to an antiadhesive barrier (Seprafilm) in adhesion prevention: an experimental study on mice.
London, UK
2 hours ago
1 Received
- - This study aimed to evaluate the effectiveness of taurolidine, heparin, and Seprafilm in preventing postoperative adhesions using a mouse model with cecal abrasion.
- - Results showed that while all treatments reduced adhesion severity compared to the control group, heparin provided the best results but had a significantly higher mortality rate due to bleeding.
- - The study suggests that taurolidine could be a potential alternative to Seprafilm for adhesion prevention, although further research is needed to confirm its effectiveness.
$100 - $150
Hourly Rate
The effect of taurolidine on experimental thrombus formation.
London, UK
2 hours ago
1 Received
- Venous thrombosis poses a health risk in clinics, and this study evaluates the impact of taurolidine, an antimicrobial agent, on thrombus formation compared to low-molecular weight heparin.
- Four groups of Wistar-Albino rats were administered different treatments, and measurements were taken to assess thrombus weight and coagulation factors.
- Results indicated that taurolidine reduced thrombus weight but was less effective than low-molecular weight heparin, possibly due to its limited impact on certain coagulation factors.
$100 - $150
Hourly Rate
Taurolidine-citrate lock solution (TauroLock) significantly reduces CVAD-associated grampositive infections in pediatric cancer patients.
London, UK
2 hours ago
1 Received
- Taurolidin/Citrate (TauroLock) shows potential in reducing bloodstream infections (BSIs) caused by coagulase-negative staphylococci (CoNS) in pediatric cancer patients with central venous access devices (CVADs).
- A study comparing two groups over four years found that the group using TauroLock had significantly fewer BSIs (12%) compared to the heparin group (47%).
- The results indicate that using TauroLock markedly decreases both the number of BSIs and their incidence density, suggesting it's a more effective lock solution for preventing infections in this patient population.
$100 - $150
Hourly Rate