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Rational design and modular synthesis of biodegradable ionizable lipids via the Passerini reaction for mRNA delivery.
Proc Natl Acad Sci U S A
February 2025
Leslie Dan Faculty of Pharmacy, University of Toronto, Toronto, ON M5S 3M2, Canada.
The ionizable lipid component of lipid nanoparticle (LNP) formulations is essential for mRNA delivery by facilitating endosomal escape. Conventionally, these lipids are synthesized through complex, multistep chemical processes that are both time-consuming and require significant engineering. Furthermore, the development of new ionizable lipids is hindered by a limited understanding of the structure-activity relationships essential for effective mRNA delivery.
View Article and Find Full Text PDFBoosting Electrode Performance and Bubble Management via Direct Laser Interference Patterning.
ACS Appl Mater Interfaces
January 2025
Institute of Fluid Dynamics, Helmholtz-Zentrum Dresden-Rossendorf, 01328 Dresden, Germany.
Article Synopsis
- Laser-structuring techniques, particularly Direct Laser Interference Patterning, can significantly enhance the performance of pure Ni electrodes in water electrolysis by optimizing their structure.
- A study revealed that the spatial distance between laser-structures is critical for improving electrode performance, resulting in an increase in the electrochemically active surface area by up to 12 times compared to nonstructured electrodes.
- Optimal structuring leads to lower onset potential and overpotential during the oxygen evolution reaction due to the superhydrophilic surface, which enhances bubble growth dynamics and minimizes electrode resistance.
Intrinsically Microporous Polyimides Based on a Rigid-Soft Structure for Hydrogen Separation.
ACS Appl Mater Interfaces
January 2025
School of Materials and Energy, Guangdong University of Technology, Guangzhou 510006, China.
Polyimide (PI)-based gas separation membranes are of great interest in the field of H purification owing to their good thermal stability, chemical stability, and mechanical properties. Among polyimide-based membranes, intrinsically microporous polyimides are easily soluble in common organic solvents, showing great potential for fabricating hollow fiber gas separation membranes. However, based on the solution-diffusion model, improving the free volume or the movability of polymer chains can improve gas permeability, but would result in poor thermal stability.
View Article and Find Full Text PDFMolecular dynamics simulations of the structure and dynamics in mixtures of ionic liquids and alcohols.
Phys Chem Chem Phys
January 2025
Department of Chemistry, Faculty of Nano and Bio Science and Technology, Persian Gulf University, Bushehr 75168, Iran.
Molecular dynamics simulations were conducted on mixtures of ionic liquids (ILs) and alcohols, specifically methanol, ethanol, and 1-propanol. Two different ILs, [Mmim][MeSO] and [Bmim][MeSO], were used with varying alcohol mole fractions to investigate the impact of alkyl chain length of cations, alcohol types, and alcohol concentrations on different structural and dynamic properties. Unique characteristics of the ILs were observed due to the varying polarity of solvents and the creation of diverse local environments surrounding the ILs.
View Article and Find Full Text PDFEarly events in G-quadruplex folding captured by time-resolved small-angle X-ray scattering.
Nucleic Acids Res
January 2025
Department of Medicine, UofL Health Brown Cancer Center, University of Louisville, Louisville KY, 505 S Hancock St, Louisville, KY 40202, United States.
Time-resolved small-angle X-ray experiments are reported here that capture and quantify a previously unknown rapid collapse of the unfolded oligonucleotide as an early step in the folding of hybrid 1 and hybrid 2 telomeric G-quadruplex structures. The rapid collapse, initiated by a pH jump, is characterized by an exponential decrease in the radius of gyration from 24.3 to 12.
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