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Sexual Dimorphism in the Downregulation of Extracellular Matrix Genes Contribute to Aortic Structural Stiffness in Female Mice.
Am J Physiol Heart Circ Physiol
January 2025
Vascular Biology Center and Department of Medicine, Medical College of Georgia at Augusta University, Augusta, GA USA.
The contribution of sex hormones to cardiovascular disease, including arterial stiffness, is established; however, the role of sex chromosome interaction with sex hormones, particularly in women, is lagging. Arterial structural stiffness depends on the intrinsic properties and transmural wall geometry that comprise a network of cells and extracellular matrix (ECM) proteins expressed in a sex-dependent manner. In this study, we used four-core genotype (FCG) mice to determine the relative contribution of sex hormones versus sex chromosomes or their interaction with arterial structural stiffness.
View Article and Find Full Text PDFExploration of the dynamics of otic capsule and intracochlear pressure: Numerical insights with experimental validation.
J Acoust Soc Am
January 2025
Department of Otorhinolaryngology, Head and Neck Surgery, University Hospital Zurich, University of Zurich, Zurich, Switzerland.
The otic capsule and surrounding temporal bone exhibit complex 3D motion influenced by frequency and location of the bone conduction stimulus. The resultant correlation with the intracochlear pressure is not sufficiently understood, thus is the focus of this study, both experimentally and numerically. Experiments were conducted on six temporal bones from three cadaver heads, with BC hearing aid stimulation applied at the mastoid and classical BAHA locations across 0.
View Article and Find Full Text PDFTuning Colloidal Gel Properties: The Influence of Central and Noncentral Forces.
Langmuir
January 2025
Department of Materials, ETH Zurich, 8093 Zurich, Switzerland.
Colloidal gels, ubiquitous in industrial applications, can undergo reversible solid-to-liquid transitions. Recent work demonstrates that adding surface roughness to primary particles enhances the toughness and influences the self-healing properties of colloidal gels. In the present work, we first use colloidal probe atomic force microscopy (CP-AFM) to assess the quantitative changes in adhesive and frictional forces between thermoresponsive particles as a function of their roughness.
View Article and Find Full Text PDFMicrofluidic-assisted sol-gel preparation of monodisperse mesoporous silica microspheres with controlled size, surface morphology, porosity and stiffness.
Nanoscale
January 2025
National Engineering Research Center for Colloidal Materials, School of Chemistry & Chemical Engineering, Shandong University, Jinan 250100, P. R. China.
The controllable synthesis of monodisperse mesoporous silica microspheres with unique physicochemical properties is becoming increasingly important for a variety of applications such as catalysts, chromatography, drug delivery and sensors. Here, we report a facile microfluidic-assisted sol-gel method for the preparation of silica microspheres with precisely controlled properties such as the size of the microspheres, the surface morphology, porosity and stiffness. All these properties can be manipulated by changing specific synthesis parameters, such as changing the microfluidic channels to tune the size of the microdroplets (tens to hundreds of microns), changing the contents of the precursor solution to manipulate the surface morphology (wrinkled to smooth surface) and changing the gelation/annealing conditions to tune the porosity (surface area up to 1021 m g) and stiffness of the microspheres (elastic modulus tunable from 0.
View Article and Find Full Text PDFSodium caseinate‑sodium alginate binary complex stabilized W/O/W emulsion gels loaded with proanthocyanidins from Aronia melanocarpa (Michx.) Elliott: Formation, structure, stability, in vitro gastrointestinal digestion.
Int J Biol Macromol
January 2025
College of Food Science and Engineering, Changchun University, Changchun 130022, China. Electronic address:
This study developed a W/O/W emulsion gel encapsulating proanthocyanidins from Aronia melanocarpa (Michx.) Elliott (APC) using polyglycerol ricinoleate (PGPR) as the lipophilic emulsifier and sodium caseinate (NaCN)-alginate (Alg) as the hydrophilic emulsifier. The optimal preparation process was established based on particle size, zeta potential, phase separation, centrifugal stability, and microscopic morphology: 4.
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