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A critical view of silk fibroin for non-viral gene therapy.
Int J Biol Macromol
January 2025
National Engineering Laboratory for Modern Silk, College of Textile and Clothing Engineering, Soochow University, No. 199 Ren'ai Road, Industrial Park, Suzhou 215123, PR China. Electronic address:
Exogenous genes are inserted into target cells during gene therapy in order to compensate or rectify disorders brought on by faulty or aberrant genes. However, gene therapy is still in its early stages because of its unsatisfactory therapeutic effects which are mainly due to low transfection efficiency of vectors, high toxicity, and poor target specificity. A natural polymer with numerous bioactive sites, good mechanical qualities, biodegradability, biocompatibility, and processability called silk fibroin has gained attention as a possible gene therapy vector.
View Article and Find Full Text PDFLessons learned from 5 years of pegvaliase in US clinics: A case series.
Mol Genet Metab Rep
March 2025
Hayward Genetics Center, Dept of Pediatrics, Tulane University Medical School, New Orleans, LA, USA.
Objective: To provide insights and strategies for pegvaliase management in challenging cases with phenylketonuria (PKU) based on the first 5 years of experience with pegvaliase in real-world clinical practice.
Methods: Twelve PKU experts gathered during a one-day, in-person meeting to discuss clinical cases illustrating important lessons from their experiences treating patients with pegvaliase in real-world clinical practice. Challenges with pegvaliase experienced prior to and during treatment and corresponding strategies to overcome them were discussed.
Topological interface states (TISs), known for their distinctive capabilities in manipulating electromagnetic waves, have attracted significant interest. However, in conventional all-dielectric one-dimensional photonic crystal (1DPC) heterostructures, TISs strongly depend on incident angle, which limits their practical applications. Here, we realize an angle-independent TIS in 1DPC heterostructures containing hyperbolic metamaterials (HMMs) for transverse magnetic polarized waves.
View Article and Find Full Text PDFImpact of Botfly Parasitism on the Behavior of Mantled Howler Monkeys.
Am J Primatol
January 2025
Primate Behavioral Ecology Lab, Instituto de Neuro-etología, Universidad Veracruzana, Xalapa, México.
Parasitism, a widespread nutrient acquisition strategy among animals, results from a long evolutionary history where one species derives its metabolic needs from another. Parasites can significantly reduce host fitness, affecting reproduction, growth, and survivability. Vertebrate hosts exhibit defensive strategies against parasites, including "sickness behaviors" such as lethargy and self-grooming to remove ectoparasites.
View Article and Find Full Text PDFResolving tissue complexity by multimodal spatial omics modeling with MISO.
Nat Methods
January 2025
Statistical Center for Single-Cell and Spatial Genomics, Department of Biostatistics, Epidemiology and Informatics, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA.
Spatial molecular profiling has provided biomedical researchers valuable opportunities to better understand the relationship between cellular localization and tissue function. Effectively modeling multimodal spatial omics data is crucial for understanding tissue complexity and underlying biology. Furthermore, improvements in spatial resolution have led to the advent of technologies that can generate spatial molecular data with subcellular resolution, requiring the development of computationally efficient methods that can handle the resulting large-scale datasets.
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