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An assessment of the progress made in the implementation of the regional framework for cholera prevention and control in the WHO African region.
BMJ Glob Health
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Emergency Preparedness and Response, WHO Regional Office for Africa, Brazzaville, Congo.
High-burden cholera outbreaks, spreading beyond the traditional cholera-endemic countries, have been reported since 2021 in the WHO African region. Member states in the region have committed to the global goal of cholera elimination by 2030. To track progress towards this goal, WHO-African countries adopted a regional cholera prevention and control framework in 2018.
View Article and Find Full Text PDFSelf-assembled HO-1i-Pt(IV) nanomedicine targeting p38/MAPK and MDR pathways for cancer chemo-immunotherapy.
J Control Release
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Department of Chemical Biology and Tianjin Key Laboratory on Technologies Enabling Development of Clinical Therapeutics and Diagnostics, School of Pharmacy, Tianjin Medical University, Tianjin 300070, China; Key Laboratory of Immune Microenvironment and Disease of the Ministry of Education, Tianjin Medical University, Tianjin 300070, China. Electronic address:
Platinum(II)-based antitumor drugs are widely used in clinics but limited by severe side effects and resistance. Multi-target Platinum(IV) complexes are emerging as ideal alternatives. Heme oxygenase-1 (HO-1) works as a rate-limiting step in heme degradation and is overexpressed in malignant tumors.
View Article and Find Full Text PDFAssessing the potential effects of climate change on the morphodynamics of the tropical coral reef islands in the Gulf of Mannar, Indian Ocean.
J Environ Manage
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Physical Oceanography Division, CSIR- National Institute of Oceanography, Dona Paula, 403 004, Goa, India; School of Oceanography, Academy of Scientific and Innovative Research (AcSIR), Ghaziabad, 201 002, India. Electronic address:
Low-lying and small tropical coral reef islands around the world are extremely vulnerable to the effects of global environmental change caused by the combination of anthropogenic climate change and escalating extreme hydrodynamic events. Erosion and inundation are anticipated to physically destabilize the tropical coral reef islands, rendering them uninhabitable within the next century. Therefore, it is crucial to assess the repercussions of these hazardous events on the delicate reef island ecosystem in order to conserve and ensure sustainable management.
View Article and Find Full Text PDFAssessment of the effectiveness of Monte Carlo Simulation for dose control at the Moroccan Boukhalef ionization facility.
Appl Radiat Isot
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Department of Physics, Nuclear Physics and Techniques Team, Faculty of Science, Ibn Tofail University, Kenitra, Morocco.
Controlling the absorbed dose received by a target is a major challenge encountered during ionizing radiation applications. For experimentally measuring absorbed dose, dosimetric systems are used. On the other hand, in addition to experimental methods of dose measurement, there are other alternatives for calculating absorbed doses, these are numerical methods based on the Monte Carlo method which are very sophisticated and widely used throughout the world.
View Article and Find Full Text PDFHyaluronic acid-conjugated lipid nanocarriers in advancing cancer therapy: A review.
Int J Biol Macromol
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Department of Respiration, Liaocheng People's Hospital, Liaocheng, Shandong, China. Electronic address:
Lipid nanoparticles are obtaining significant attention in cancer treatment because of their efficacy at delivering drugs and reducing side effects. These things are like a flexible platform for getting anticancer drugs to the tumor site, especially upon HA modification, a polymer that is known to target tumors overexpressing CD44. HA is promising in cancer therapy because it taregtes tumor cells by binding onto CD44 receptors, which are often upregulated in cancer cells.
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