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Embryonic exposure to valproic acid and neonicotinoid deteriorates the hyperpolarizing GABA shift and impairs long-term potentiation of excitatory transmission in the local circuit of intermediate medial mesopallium of chick telencephalon.
Cereb Cortex
February 2025
Faculty of Pharmaceutical Sciences, Health Sciences University of Hokkaido, Kanazawa 1757, 061-0293 Tobetsu, Japan.
Embryonic exposure to valproic acid and imidacloprid (a neonicotinoid insecticide) impairs filial imprinting in hatchlings, and the deteriorating effects of valproic acid are mitigated by post-hatch injection of bumetanide, a blocker of the chloride intruder Na-K-2Cl cotransporter 1. Here, we report that these exposures depolarized the reversal potential of local GABAergic transmission in the neurons of the intermediate medial mesopallium, the pallial region critical for imprinting. Furthermore, exposure increased field excitatory post-synaptic potentials in pre-tetanus recordings and impaired long-term potentiation (LTP) by low-frequency tetanic stimulation.
View Article and Find Full Text PDFTsc1 deletion in Purkinje neurons disrupts the axon initial segment, impairing excitability and cerebellar function.
Neurobiol Dis
February 2025
Department of Biology, Miami University, Oxford, OH 45056, United States. Electronic address:
Loss-of-function mutations in tuberous sclerosis 1 (TSC1) are prevalent monogenic causes of autism spectrum disorder (ASD). Selective deletion of Tsc1 from mouse cerebellar Purkinje neurons has been shown to cause several ASD-linked behavioral impairments, which are linked to reduced Purkinje neuron repetitive firing rates. We used electrophysiology methods to investigate why Purkinje neuron-specific Tsc1 deletion (Tsc1) impairs Purkinje neuron firing.
View Article and Find Full Text PDFPregnenolone sulfate potentiates tetrodotoxin-resistant Na channels to increase the excitability of dural afferent neurons in rats.
J Headache Pain
February 2025
Brain Science & Engineering Institute, Kyungpook National University, 2177 Dalgubeol-daero, Jung-gu, Daegu, 41940, Republic of Korea.
Background: Although peripheral administration of pregnenolone sulfate (PS) has been reported to produce pronociceptive effects, the mechanisms by which PS modulates the excitability of nociceptive neurons are poorly understood. Here, we report on the excitatory role of PS in peripheral nociceptive neurons, focusing on its effects on tetrodotoxin-resistant (TTX-R) Na channels.
Methods: TTX-R Na current (I) mediated by Na1.
Sleep-wake-related changes in intracellular chloride regulate plasticity at glutamatergic cortical synapses.
Curr Biol
February 2025
Department of Pharmacology, University of Oxford, Mansfield Road, Oxford OX1 3QT, UK. Electronic address:
Wakefulness and sleep affect the brain's ability to exhibit plastic changes. For instance, the potentiation of cortical excitatory synaptic connections is associated with the active period, when animals are mainly awake. It is unclear, however, how changes in neuronal physiology that are associated with sleep-wake history, affect the mechanisms responsible for synaptic plasticity.
View Article and Find Full Text PDFContinuously Tuning Negative Capacitance via Field-Driven Polar Skyrmions in Ferroelectric Trilayer Wrinkled Films.
ACS Nano
March 2025
School of Materials Science and Engineering, Beijing Institute of Technology, Beijing 100081, China.
Polar topological structures have emerged as a frontier in research due to their significant potential in nanoscale electronic devices. The periodic and ordered arrangement, as well as the dynamic control mechanisms, are essential for their practical applications. Here, we present theoretical phase-field simulations that reveal the periodic and ordered arrangement of skyrmions and in-plane vortices within (SrTiO)/(PbTiO)/(SrTiO) checkerboard-patterned wrinkled trilayer films.
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