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Optimized convolutional neural network using African vulture optimization algorithm for the detection of exons.
Sci Rep
January 2025
Department of Communication Engineering, School of Electronics Engineering, Vellore Institute of Technology, Vellore, Tamil Nadu, 632014, India.
The detection of exons is an important area of research in genomic sequence analysis. Many signal-processing methods have been established successfully for detecting the exons based on their periodicity property. However, some improvement is still required to increase the identification accuracy of exons.
View Article and Find Full Text PDFObservation of ultraviolet photothermoelectric bipolar impulse in gallium-based heterostructure nanowires.
Nat Commun
January 2025
Key Laboratory of Advanced Photonic and Electronic Materials, Key Laboratory of Optoelectronic Devices and Systems with Extreme Performances of MOE and School of Electronic Science and Engineering, Nanjing University, Nanjing, 210093, China.
The incorporation of thermal dynamics alongside conventional optoelectronic principles holds immense promise for advancing technology. Here, we introduce a GaON/GaN heterostructure-nanowire ultraviolet electrochemical cell of observing a photothermoelectric bipolar impulse characteristic. By leveraging the distinct thermoelectric properties of GaON/GaN, rapid generation of hot carriers establishes bidirectional instantaneous gradients in concentration and temperature within the nanoscale heterostructure via light on/off modulation.
View Article and Find Full Text PDFSite-specific substitution in atomically precise carboranethiol-protected nanoclusters and concomitant changes in electronic properties.
Nat Commun
January 2025
DST Unit of Nanoscience (DST UNS) and Thematic Unit of Excellence (TUE), Department of Chemistry, Indian Institute of Technology, Madras, Chennai, 600036, India.
We report the synthesis of [Ag(o-CBT)] abbreviated as Ag, a stable 8e⁻ anionic cluster with a unique Ag@Ag@Ag core-shell structure, where o-CBT is ortho-carborane-1-thiol. By substituting Ag atoms with Au and/or Cu at specific sites we created isostructural clusters [AuAg(o-CBT)] (AuAg), [AgCu(o-CBT)] (AgCu) and [AuAgCu(o-CBT)] (AuAgCu). These substitutions make systematic modulation of their structural and electronic properties.
View Article and Find Full Text PDFThermal-Sensitive Artificial Ionic Skin with Environmental Stability and Self-Healing Property.
ACS Appl Mater Interfaces
January 2025
Key Laboratory of Organic Optoelectronics and Molecular Engineering and Laboratory of Flexible Electronics Technology, Department of Chemistry, Tsinghua University, Beijing 100084, P. R. China.
Wearable temperature-sensitive electronic skin enables robots to rapidly detect environmental changes and respond intelligently, thereby reducing temperature-related mechanical failures. Additionally, this temperature-sensitive skin can measure and record the temperature of external objects, broadening its potential applications in the medical field. In this study, we designed a thermally sensitive artificial ionic skin using ionic liquids (ILs) as solvents and carbon nanotubes (CNTs) as thermally conductive fillers.
View Article and Find Full Text PDFThe absorption, distribution, metabolism and elimination characteristics of small interfering RNA therapeutics and the opportunity to predict disposition in pregnant women.
Drug Metab Dispos
January 2025
ReNAgade Therapeutics Management Inc, Cambridge, Massachusetts. Electronic address:
Small interfering RNA (siRNA) therapeutics represent an emerging class of pharmacotherapy with the potential to address previously hard-to-treat diseases. Currently approved siRNA therapeutics include lipid nanoparticle-encapsulated siRNA and tri-N-acetylated galactosamine-conjugated siRNA. These siRNA therapeutics exhibit distinct pharmacokinetic characteristics and unique absorption, distribution, metabolism, and elimination (ADME) properties.
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