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Noninvasive ocular delivery of adalimumab-loaded nanostructured lipid carriers for targeted retinitis pigmentosa therapy.
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Group of Pathophysiology and Therapies for Vision Disorders, Príncipe Felipe Research Center (CIPF), Eduardo Primo Yúfera 3, Valencia 46012, Spain; Joint Research Unit on Rare Diseases CIPF-Health Research Institute Hospital La Fe (IIS-La Fe), Valencia 46026, Spain; Biomedical Research Networking Center in Rare Diseases (CIBER-ER), Institute of Health Carlos III, Monforte de Lemos, 3-5. Pabellón 11, Madrid 28029, Spain; Catholic University of Valencia (UCV), Faculty of Health Sciences, Quevedo, 2, Valencia 46001, Spain. Electronic address:
Retinitis pigmentosa is a genetically heterogeneous retinal degeneration process. There is hardly any treatment available. It is associated with extensive chronic inflammation and the release of proinflammatory cytokines such as TNFα.
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School of Physics and Optoelectronics, South China University of Technology, Guangzhou 510640, China.
Raman spectroscopy has demonstrated significant potential in molecular detection, analysis, and identification, particularly when it adopts single-molecule surface-enhanced Raman scattering (SM-SERS) substrates. A recent SM-SERS scheme incorporates two-fold Raman enhancement mechanisms: the electromagnetic enhancement enabled by a plasmonic nanogap hotspot formed from gold sphere nanoparticles sitting on a gold mirror and the chemical enhancement enabled by a two-dimensional material, WS, inserted into the nanogap. In this work we integrate multiple advanced concepts and techniques to achieve remarkable performance improvements of SM-SERS.
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Department of Electronic and Information Engineering, Tokyo University of Agriculture and Technology, Koganei-shi, Tokyo, 184-8588 Japan.
Unlabelled: Face masks became a part of everyday life during the SARS-CoV-2 pandemic. Previous studies showed that the face cognition mechanism involves holistic face processing, and the absence of face features could lower the cognition ability. This is opposed to the experience during the pandemic, when people could correctly recognize faces, although the mask covered a part of the face.
View Article and Find Full Text PDFMorphological covariates of the ontogenetic shift from nauplii to copepodite prey in larval fish.
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Northwest Atlantic Fisheries Centre, Fisheries and Oceans Canada, St. John's, Newfoundland Island, Canada.
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View Article and Find Full Text PDFModified double-flanged technique in the management of dislocated posterior intraocular lenses.
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Department of Ophthalmology, Sisli Hamidiye Etfal Education and Research Hospital, Halaskargazi Street, 34371, Istanbul, Turkey.
Purpose: To evaluate the modified double-flanged technique in cases of subluxated foldable single-piece intraocular lenses (IOLs).
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