Syntheses and structure-activity relationships (SAR) of cGMP selective phosphodiesterase inhibitors are discussed. Potent and selective inhibitors are produced when the C-2 position of tetracyclic guanine 1 is substituted with alkyl chains containing six carbon atoms.
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| http://dx.doi.org/10.1016/s0960-894x(98)00681-7 | DOI Listing |
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