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Novel insertions in the mitochondrial maxicircle of , a mouse trypanosome.
Parasitology
October 2022
Guangdong Provincial Key Laboratory of Aquatic Economic Animals, State Key Laboratory of Biocontrol, School of Life Sciences, Sun Yat-Sen University, Guangzhou 510275, The People's Republic of China.
is a, globally distributed, mouse-specific haemoflagellate, of the family Trypanosomatidae, which shares similar characteristics in morphology with . The kinetoplast (mitochondrial) DNA of Trypanosomatidae flagellates is comprised of catenated maxicircles and minicircles. However, genetic information on the kinetoplast remains largely unknown.
View Article and Find Full Text PDFInfection with or may promote the spread of .
Parasitology
May 2021
Center for Parasitic Organisms, State Key Laboratory of Biocontrol, School of Life Sciences, Sun Yat-Sen University, Guangzhou510275, China.
Toxoplasma gondii can infect almost all warm-blooded vertebrates with pathogensis being largely influenced by the host immune status. As important epidemiological hosts, rodents are globally distributed and are also commonly found infected with haemoflagellates, such as those in the genus Trypanosoma. We here address whether and how co-infection with trypanosomes can influence T.
View Article and Find Full Text PDFCrosstalk between TAp73 and TGF-β in fibroblast regulates iNOS expression and Nrf2-dependent gene transcription.
Free Radic Biol Med
April 2019
Institute for Integrative Biology of the Cell (I2BC) CEA, CNRS, Univ. Paris-Sud, Université Paris-Saclay, UMR9198, F-91198, Gif-sur-Yvette Cedex, France. Electronic address:
Article Synopsis
- iNOS activity has both anti-tumor and carcinogenic effects, with p53 playing a key role in downregulating its expression to prevent DNA damage.
- TAp73, a p53 homologue, was found to enhance iNOS expression in certain cells, suggesting it regulates its expression differently than p53.
- The study indicates that TAp73 and TGF-β work together to control iNOS levels, impacting how cells respond to stress and fight off pathogens.
The effect of normal human serum on the mouse trypanosome Trypanosoma musculi in vitro and in vivo.
Exp Parasitol
January 2018
Center for Parasitic Organisms, State Key Laboratory of Biocontrol, School of Life Sciences, Sun Yat-Sen University, Guangzhou 510275, PR China. Electronic address:
Trypanosoma musculi, a common blood flagellate found in mice, is similar in morphology and life cycle to the rat trypanosome T. lewisi. Both species belong to the subgenus Herpetosoma, and as T.
View Article and Find Full Text PDFInfection in Mice Critically Relies on Mannose Receptor-Mediated Arginase Induction by a KHC1 Kinesin H Chain Homolog.
J Immunol
September 2017
Laboratoire de Parasitologie, UMR 177 IRD/CIRAD "INTERTRYP, " Université Bordeaux, F-33000 Bordeaux, France;
Arginase activity induction in macrophages is an escape mechanism developed by parasites to cope with the host's immune defense and benefit from increased host-derived growth factor production. We report that arginase expression and activity were induced in macrophages during mouse infection by , a natural parasite of this host. This induction was reproduced in vitro by excreted/secreted factors of the parasite.
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