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Differential biodistribution of intravenously administered endothelial progenitor and cytotoxic T-cells in rat bearing orthotopic human glioma.
BMC Med Imaging
June 2013
Cellular and Molecular Imaging Laboratory, Radiology, Henry Ford Hospital, Detroit, MI, USA.
Background: A major challenge in the development of cell based therapies for glioma is to deliver optimal number of cells (therapeutic dose) to the tumor. Imaging tools such as magnetic resonance imaging (MRI), optical imaging, positron emission tomography (PET) and single-photon emission computed tomography (SPECT) has been used in cell tracking and/or biodistribution studies. In this study, we evaluate the dynamic biodistribution of systemic injected labeled cells [human cord blood derived endothelial progenitor cells (EPCs) and cytotoxic T-cells (CTLs)] in rat glioma model with in vivo SPECT imaging.
View Article and Find Full Text PDFIntegrins and monocyte migration to the ischemic myocardium.
J Invest Surg
April 2010
Department of Surgery, Dalhousie University, Halifax, Nova Scotia, Canada.
Aims: Characterize mononuclear cell migration after acute-myocardial infarction (MI).
Material And Methods: Male Lewis rats underwent a left thoracotomy and ligation of the left anterior descending coronary artery (MI group). Control animals underwent thoracotomy without ligation (Sham group).
Detection of abdominal aortic graft infection: comparison of magnetic resonance imaging and indium-labeled white blood cell scanning.
Ann Vasc Surg
September 2007
Department of Cardiothoracic and Vascular Surgery, University Hospital Aarhus/Skejby, Aarhus/Skejby, Denmark.
Infected abdominal aortic grafts rank as one of the most severe complications of vascular surgery, with high mortality and morbidity. The incidence of infection after prosthetic aortic reconstruction is 1-3%. Diagnosis of vascular graft infection can be occasionally difficult.
View Article and Find Full Text PDFFused SPECT/CT imaging of Peri-iliopsoas infection using Indium-111-labeled leukocytes.
Clin Nucl Med
December 2006
University Hospitals of Cleveland, Case Western Reserve University School of Medicine, Department of Radiology, Division of Nuclear Medicine, Cleveland, Ohio 44106, USA.
Nuclear imaging with In-111-labeled leukocytes has become an instrumental tool in localizing sites of infection and is superior to Ga-67 in localizing abdominal and pelvic abscesses resulting from absence of a normal bowel excretory pathway. Labeled white blood cells (WBCs) localize at sites of infection through diapedesis, chemotaxis, and enhanced vascular permeability and can thus be used to identify infection. The accuracy of this functional imaging modality can be enhanced by fusing SPECT images of labeled WBC with CT images that provide anatomic detail to facilitate reading as illustrated in the case described.
View Article and Find Full Text PDFImproved diagnosis of aortobifemoral vascular graft infection by In-111-labeled leukocyte SPECT.
Clin Nucl Med
June 2006
Department of Nuclear Medicine, Mont-Godinne Medical Center, Université Catholique de Louvain, Yvoir, Belgium.
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