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Designing Fluorescent Interfaces at Hotspots in a Plasmonic Nanopore for Homologous Optoelectronic Sensing.
Small
January 2025
Department of Chemistry and the MOE Key Laboratory of Spectrochemical Analysis & Instrumentation, College of Chemistry and Chemical Engineering, Xiamen University, Xiamen, 361005, P. R. China.
In this work, a site-selective functionalization strategy is proposed for modifying fluorescent dyes in the plasmonic nanopore, which highlights building optoelectronic dual-signal sensing interfaces at "hotspots" locations to construct multiparameter detection nanosensor. Finite-difference time-domain (FDTD) simulations confirmed the high-intensity electromagnetic field due to plasmonic nanostructure. It is demonstrated that adjusting the distance between the nanopore inner wall and fluorophore prevented the fluorescence quenching, resulting in more than a thirty fold fluorescence enhancement.
View Article and Find Full Text PDFCarbene-catalyzed chirality-controlled site-selective acylation of saccharides.
Nat Commun
January 2025
School of Chemistry, Chemical Engineering, and Biotechnology, Nanyang Technological University, Singapore, 637371, Singapore.
Acylation stands as a fundamental process in both biological pathways and synthetic chemical reactions, with acylated saccharides and their derivatives holding diverse applications ranging from bioactive agents to synthetic building blocks. A longstanding objective in organic synthesis has been the site-selective acylation of saccharides without extensive pre-protection of alcohol units. In this study, we demonstrate that by simply altering the chirality of N-heterocyclic carbene (NHC) organic catalysts, the site-selectivity of saccharide acylation reactions can be effectively modulated.
View Article and Find Full Text PDFSupramolecular Host:Guest Arrays Site-Selectively Recognize Peptide Phosphorylation and Kinase Activity.
J Am Chem Soc
January 2025
Department of Chemistry, University of California─Riverside, Riverside, California 92521, United States.
A synergistic combination of cationic styrylpyridinium dyes and water-soluble deep cavitand hosts can recognize phosphorylated peptides with both site- and state-selectivity. Two mechanisms of interaction are dominant: either the cationic dye interacts with Trp residues in the peptide or the host:dye pair forms a heteroternary complex with the peptide, driven by both strong dye-peptide and cavitand-peptide binding ( values up to 4 μM). The presence of multiple recognition mechanisms results in varying fluorescence responses dependent on the phosphorylation state and position, eliminating the need for covalent modification of the peptide target.
View Article and Find Full Text PDFMolecular Engineering of Ultrabright Biomimetic NanoGhost for Site-Selective Tumor Imaging and Biodistribution.
Adv Healthc Mater
December 2024
School of Biochemical Engineering, Indian Institute of Technology (BHU) Varanasi, Varanasi, Uttar Pradesh, 221005, India.
Optically active ultrabright imaging agents are shown to delineate tumor location with deep tissue visualization in pre noclinical tumor models. NanoGhosts (NGs) particles are reconstructed from the cell membrane and integrated with organic fluorophores to attain ultra-brightness for solid tumor imaging. Moreover, the integration of amphiphilic and lipophilic molecules reveals structural characteristics of NGs (≈70 nm), which also alter their brightness.
View Article and Find Full Text PDFSelective on-site detection and quantification of polystyrene microplastics in water using fluorescence-tagged peptides and electrochemical impedance spectroscopy.
J Hazard Mater
December 2024
School of Engineering and Computer Science, University of Victoria, Victoria, BC V8P 5C2, Canada. Electronic address:
In this study, we developed a method for the on-site selective detection and quantification of microplastics in various water matrices using fluorescence-tagged peptides combined with electrochemical impedance spectroscopy (EIS). Among the types of plastics found in seawater, polystyrene (PS) microplastics were selected. Fluorometry, scanning electron microscopy (SEM), and Raman spectroscopy were used to verify the specific interaction of these peptides with PS spherical particles of different sizes (ranging from 0.
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