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Rethinking the residual approach: leveraging statistical learning to operationalize cognitive resilience in Alzheimer's disease.
Brain Inform
January 2025
Department of Neurology, Massachusetts General Hospital, Harvard Medical School, Boston, MA, 02114, USA.
Cognitive resilience (CR) describes the phenomenon of individuals evading cognitive decline despite prominent Alzheimer's disease neuropathology. Operationalization and measurement of this latent construct is non-trivial as it cannot be directly observed. The residual approach has been widely applied to estimate CR, where the degree of resilience is estimated through a linear model's residuals.
View Article and Find Full Text PDFHelioseismic inference of the solar radiative opacity.
Nat Commun
January 2025
Los Alamos National Laboratory, Los Alamos, NM, 87545, USA.
The Sun is the most studied of all stars, and thus constitutes a benchmark for stellar models. However, our vision of the Sun is still incomplete, as illustrated by the current debate on its chemical composition. The problem reaches far beyond chemical abundances and is intimately linked to microscopic and macroscopic physical ingredients of solar models such as radiative opacity, for which experimental results have been recently measured that still await theoretical explanations.
View Article and Find Full Text PDFRelationship between structural properties and biological activity of (-)-menthol and some menthyl esters.
Comput Biol Chem
January 2025
Department of Natural Sciences, Novosibirsk State University, Novosibirsk 630090, Russia. Electronic address:
Menthol is a naturally occurring cyclic terpene alcohol and is the major component of peppermint and corn mint essential oils extracted from Mentha piperita L. and Mentha arvensis L..
View Article and Find Full Text PDF14-3-3 promotes sarcolemmal expression of cardiac Ca1.2 and nucleates isoproterenol-triggered channel superclustering.
Proc Natl Acad Sci U S A
February 2025
Department of Physiology and Membrane Biology, University of California Davis, Davis, CA 95616.
The L-type Ca channel (Ca1.2) is essential for cardiac excitation-contraction coupling. To contribute to the inward Ca flux that drives Ca-induced-Ca-release, Ca1.
View Article and Find Full Text PDFStrigolactones regulate Bambusa multiplex sheath senescence by promoting chlorophyll degradation.
Tree Physiol
January 2025
State Key Laboratory of Tree Genetics and Breeding, Co-Innovation Center for Sustainable Forestry in Southern China, Bamboo Research Institute, Key Lab of National Forestry and Grassland Administration on Subtropical Forest Biodiversity Conservation, School of Life Sciences, Nanjing Forestry University, Nanjing 210037, China.
Culm sheaths are capable of photosynthesis and are an important class of non-leaf organs in bamboo plants. The source-sink interaction mechanism has been found to play an important role in the interaction between culm sheaths and internodes in Bambusa multiplex. Research on the regulatory mechanisms of culm sheath senescence is important for the study of internode growth, but reports in this regard are limited.
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