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Development and feasibility testing of a new device for home-based leg heat therapy in patients with lower extremity peripheral artery disease.
J Vasc Surg Cases Innov Tech
February 2025
Department of Health and Kinesiology, Purdue University, West Lafayette, IN.
People with symptomatic lower extremity peripheral artery disease (PAD) suffer from severe leg pain, walking impairment, and reduced quality of life, but few effective treatments are available. Emerging evidence suggests that regular heat therapy (HT) may improve cardiovascular and physical function in patients with PAD. However, the lack of accessible, practical modalities for unsupervised HT, especially for elderly individuals, has hindered clinical implementation.
View Article and Find Full Text PDFAn mRNA vaccine induces antimycobacterial immunity by activating DNA damage repair and autophagy.
Mol Ther Nucleic Acids
March 2025
Department of Microbiology, School of Life Sciences, Fudan University, Shanghai 200438, China.
Effective vaccines are urgently needed for the control of tuberculosis (TB). Here, we report that an mRNA TB vaccine is highly effective and exhibits both prophylactic and therapeutic activity in the zebrafish model of TB. Adult zebrafish immunized with the mRNA vaccine survived significantly longer after challenge compared to those immunized with the DNA vaccine.
View Article and Find Full Text PDFProtein stabilization in spray drying and solid-state storage by using a 'molecular lock' - exploiting bacterial adaptations for industrial applications.
RSC Chem Biol
December 2024
SSPC - The Science Foundation Ireland Research Centre for Pharmaceuticals, Department of Chemical Sciences, Bernal Institute, University of Limerick Limerick Ireland
Small, stable biomedicines, like peptides and hormones, are already available on the market as spray dried formulations, however large biomolecules like antibodies and therapeutic enzymes continue to pose stability issues during the process. Stresses during solid-state formation are a barrier to formulation of large biotherapeutics as dry powders. Here, we explore an alternative avenue to protein stabilisation during the spray drying process, moving away from the use of excipients.
View Article and Find Full Text PDFCultural adaptation, validation and standardization of the developmental screening tools ASQ:SE-2 in Iranian children.
Heliyon
December 2024
Emergency devision, Bahrami hospital, school of medicine, Tehran University of Medical Science, Tehran, Iran.
The Ages and Stages Questionnaires: Social-Emotional, Second Edition (ASQ) is a parental-report tool designed to assess the social-emotional development of young children. Its adaptation and validation in diverse cultural contexts are vital for its effective application. This study aimed to culturally adapt, validate, and standardize the ASQ for Iranian children.
View Article and Find Full Text PDFAdvanced deep transfer learning techniques for efficient detection of cotton plant diseases.
Front Plant Sci
December 2024
School of Information Technology (IT) and Engineering, Melbourne Institute of Technology, Melbourne, VIC, Australia.
Introduction: Cotton, being a crucial cash crop globally, faces significant challenges due to multiple diseases that adversely affect its quality and yield. To identify such diseases is very important for the implementation of effective management strategies for sustainable agriculture. Image recognition plays an important role for the timely and accurate identification of diseases in cotton plants as it allows farmers to implement effective interventions and optimize resource allocation.
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