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New molecular hybrids integrated with quinoxaline and pyrazole structural motifs: VGFR2 inhibitors and apoptosis inducers.
Bioorg Chem
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Department of Chemistry, Faculty of Science, Al-Azhar University, Cairo 11754 Egypt.
The vascular endothelial growth factor receptor is essential for the angiogenesis of cancer. Tumor propagation was effectively suppressed by inhibiting VEGFR-2 activity. As a result, the target quinoxaline-pyrazole hybrids were created in a way that closely resembled the structural characteristics of VEGFR-2 inhibitors.
View Article and Find Full Text PDFSensorless Junction Temperature Estimation of Onboard SiC MOSFETs Using Dual-Gate-Bias-Triggered Third-Quadrant Characteristics.
Sensors (Basel)
January 2025
School of Mechanical and Engineering, Shanghai Jiao Tong University, Shanghai 200240, China.
Silicon carbide (SiC) metal oxide semiconductor field-effect transistors (MOSFETs) are a future trend in traction inverters in electric vehicles (EVs), and their thermal safety is crucial. Temperature-sensitive electrical parameters' (TSEPs) indirect detection normally requires additional circuits, which can interfere with the system and increase costs, thereby limiting applications. Therefore, there is still a lack of cost-effective and sensorless thermal monitoring techniques.
View Article and Find Full Text PDFDetermination of Mechanical Properties of Blind Rivet Joints Using Numerical Simulations and Experimental Testing.
Materials (Basel)
January 2025
Faculty of Mechanical Engineering, University of West Bohemia, Univerzitni 2732/8, 301 00 Pilsen, Czech Republic.
This study explores the tensile performance of blind rivet joints in galvanized steel sheets, focusing on their behavior under shear and normal load conditions. Blind rivets are frequently used in structural applications due to their ease of installation and ability to be applied from one side, making them highly effective in industries like aerospace and automotive. Two types of DIN 7337-4.
View Article and Find Full Text PDFDeterminants of Human Corneal Mechanical Wave Dispersion for In Vivo Optical Coherence Elastography.
Transl Vis Sci Technol
January 2025
College of Optometry, University of Houston, Houston, TX, USA.
Purpose: To characterize frequency-dependent wave speed dispersion in the human cornea using microliter air-pulse optical coherence elastography (OCE), and to evaluate the applicability of Lamb wave theory for determining corneal elastic modulus using high-frequency symmetric (S0) and anti-symmetric (A0) guided waves in cornea.
Methods: Wave speed dispersion analysis for transient (0.5 ms) microliter air-pulse stimulation was performed in four rabbit eyes ex vivo and compared to air-coupled ultrasound excitation.
Evaluation of the Effects of Retro-Cavity Preconditioning with or Without Ethylenediaminetetraacetic Acid on Root Surface pH and Dislodgement Resistance of NeoMTA2 and Mineral Trioxide Aggregate Flow Retro-Fills: An Ex Vivo Investigation.
J Funct Biomater
December 2024
Department of Surgical Sciences and Integrated Diagnostics, University of Genoa, Viale Benedetto XV, 6, 16132 Genoa, Italy.
The aim of this study was to investigate the effects of retro-cavity preconditioning with or without 17% ethylenediaminetetraacetic acid (EDTA) solution on root surface pH as well as dislodgement resistance of NeoMTA2 and MTA Flow retro-fills. Forty-eight single-rooted human incisors were selected. After completion of endodontic treatment, root-end resections were performed, and retro-cavities were prepared.
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