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Current research trends and hotspots of boron neutron capture therapy: a bibliometric and visualization analysis.
Front Oncol
December 2024
Department of Radiation Oncology, National Cancer Center/National Clinical Research Center for Cancer/Cancer Hospital & Shenzhen Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Shenzhen, China.
Purpose: This study aimed to describe the trends, current hotspots, and future directions in boron neutron capture therapy (BNCT) through a bibliometric analysis.
Methods: Articles related to BNCT published before 2023-12-31 were retrieved from the Web of Science Core Collection database. VOSviewer, R, and CiteSpace were used for bibliometric analysis and visualization.
Interplay between A-site and oxygen-vacancy ordering, and mixed electron/oxide-ion conductivity in = 1 Ruddlesden-Popper perovskite SrNdZnO.
Chem Sci
December 2024
College of Chemistry and Chemical Engineering, Chongqing University Chongqing 401331 China
Oxygen vacancies in Ruddlesden-Popper (RP) perovskites (PV) [AO][ABO] play a pivotal role in engineering functional properties and thus understanding the relationship between oxygen-vacancy distribution and physical properties can open up new strategies for fine manipulation of structure-driven functionalities. However, the structural origin of preferential distribution for oxygen vacancies in RP structures is not well understood, notably in the single-layer ( = 1) RP-structure. Herein, the = 1 RP phase SrNdZnO was rationally designed and structurally characterized by combining three-dimensional (3D) electron diffraction and neutron powder diffraction.
View Article and Find Full Text PDFAn accelerator-based neutron source design with a thermal neutron port and an epithermal neutron port for boron neutron capture therapy.
Appl Radiat Isot
December 2024
Institute of Nuclear Techniques of Budapest University of Technology and Economics, Műegyetem Rkp 9, 1111, Budapest, Hungary.
This study presents a compact accelerator-driven neutron source design with a thermal neutron port and an epithermal neutron port for Boron Neutron Capture Therapy (BNCT), based on 10 mA 2.5 MeV protons bombarding on a 100 μm thick disc-shaped Li target with a diameter of 10 cm. The moderator consists of 2 parts, the epithermal neutron moderator and the thermal neutron moderator.
View Article and Find Full Text PDFFractionated alpha and mixed beam radiation promote stronger pro-inflammatory effects compared to acute exposure and trigger phagocytosis.
Front Cell Neurosci
December 2024
Department of Molecular Biosciences, Centre for Radiation Protection Research, The Wenner-Gren Institute, Stockholm University, Stockholm, Sweden.
Introduction And Methods: Aiming to evaluate safety aspects of a recently proposed approach to target Alzheimer's disease, we mimicked a complex boron neutron capture therapy field using a mixed beam consisting of high- and low-linear energy transfer (LET) radiation, Am alpha particles (α) and/or X-ray radiation respectively, in human microglial (HMC3) cells.
Results: Acute exposure to 2 Gy X-rays induced the strongest response in the formation of γH2AX foci 30 min post irradiation, while α- and mixed beam-induced damage (α:X-ray = 3:1) sustained longer. Fractionation of the same total dose (0.
Development of anticoincidence detector specializing in small-angle Compton scattering gamma rays for boron neutron capture therapy.
Appl Radiat Isot
December 2024
Division of Quantum and Radiation Engineering, Graduate School of Engineering, Osaka Metropolitan University, 1-2 Gakuen-cho, Naka-ku, Sakai, Osaka, 599-8570, Japan.
A novel anticoincidence detector is proposed for the measurement of 478 keV gamma radiation for evaluation of boron neutron capture therapy. The Compton continuum around the target photopeak position is effectively suppressed by measuring only the Compton gamma rays scattered at small angles from the primary detector. A numerical evaluation using Monte Carlo simulations estimated an 80% reduction in counts, and the developed prototype detector showed 4% suppression of the Compton continuum of cobalt-60 gamma rays.
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