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Biomimicry of microbial polysaccharide hydrogels for tissue engineering and regenerative medicine - A review.
Carbohydr Polym
August 2020
Department of Pharmacy, Faculty of Science, National University of Singapore, Block S4A, Level 3, 18 Science Drive 4, 117543, Singapore; NUS Graduate School for Integrative Sciences and Engineering, 21 Lower Kent Ridge Road, 119077, Singapore. Electronic address:
Hydrogels as artificial biomaterial scaffolds offer a much favoured 3D microenvironment for tissue engineering and regenerative medicine (TERM). Towards biomimicry of the native ECM, polysaccharides from Nature have been proposed as ideal surrogates given their biocompatibility. In particular, derivatives from microbial sources have emerged as economical and sustainable biomaterials due to their fast and high yielding production procedures.
View Article and Find Full Text PDFChemogenetic activation of orexin/hypocretin neurons ameliorates aging-induced changes in behavior and energy expenditure.
Am J Physiol Regul Integr Comp Physiol
May 2019
Integrative Biology and Physiology, University of Minnesota, Minneapolis, Minnesota.
Aging affects numerous physiological processes, as well as behavior. A large number of these processes are regulated, at least partially, by hypothalamic orexin neurons, and orexin tone may decrease with normal aging. In this study, we hypothesized that designer receptors exclusively activated by designer drugs (DREADD) stimulation of orexin neuronal activity will ameliorate the effect of aging on behavioral and metabolic alterations in young and middle-aged mice.
View Article and Find Full Text PDFDivergent effects of resistance and endurance exercise on plasma bile acids, FGF19, and FGF21 in humans.
JCI Insight
August 2018
Novo Nordisk Foundation Center for Basic Metabolic Research, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark.
Background: Exercise has profound pleiotropic health benefits, yet the underlying mechanisms remain incompletely understood. Endocrine FGF21, bile acids (BAs), and BA-induced FGF19 have emerged as metabolic signaling molecules. Here, we investigated if dissimilar modes of exercise, resistance exercise (RE) and endurance exercise (EE), regulate plasma BAs, FGF19, and FGF21 in humans.
View Article and Find Full Text PDFLaypersons' perceptions of the esthetics of visible anterior occlusion.
J Can Dent Assoc
December 2005
Orthodontic Graduate Program, University of Alberta, Edmonton, Alberta.
Objective: To analyze 6 different types of visible anterior occlusion, exclusive of extraoral facial features, in terms of their esthetic appeal, as perceived by 91 randomly selected adult laypersons with different levels of education in Lima, Peru.
Methods: Photographic images of 3 examples of each occlusion type (open bite [OB], deep bite [DB], crossbite [CB], end-to-end bite [EE], crowded bite [CwB] and ideal bite [IB]) were prepared. Evaluators used a visual analogue scale (VAS) to rate their perceptions of the esthetic appeal of each view.
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