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http://dx.doi.org/10.1103/physrevc.53.r2576 | DOI Listing |
Allergy Asthma Proc
January 2025
Department of Pharmacovigilance, Pharmacovigilance and Quality Assurance Group, Torii Pharmaceutical Co., Ltd., Tokyo, Japan.
Standardized quality (SQ) house-dust mite (HDM) sublingual immunotherapy tablets (10,000 Japanese allergy units [JAU], equivalent to 6 SQ-HDM in Europe and the United States) are licensed for the treatment of HDM-induced allergic rhinitis (AR) without age restriction, based on 52-week administration clinical trials. There are no large-scale data on the administration of 10,000 JAU for > 1 year in actual clinical practice. To examine the safety and effectiveness of 10,000 JAU during use for up to 3 years at real-world clinical sites in Japan.
View Article and Find Full Text PDFCell Biosci
December 2024
Assisted Reproduction Unit, Department of Obstetrics and Gynecology, Sir Run Run Shaw Hospital, School of Medicine, Zhejiang University, Hangzhou, 310016, China.
Background: Oocyte maturation defect (OMD) and early embryonic arrest result in female infertility. Previous studies have linked biallelic mutations in the PATL2 gene to OMD, yet the underlying mechanism remains largely unknown.
Results: This study uncovers three novel mutations (c.
Light Sci Appl
January 2025
Institute of Microstructure Technology (IMT), Karlsruhe Institute of Technology (KIT), Hermann-von-Helmholtzplatz 1, Eggenstein-Leopoldshafen, 76344, Germany.
The core advantage of metalenses over traditional bulky lenses lies in their thin volume and lightweight. Nevertheless, as the application scenarios of metalenses extend to the macro-scale optical imaging field, a contradiction arises between the increasing demand for large-aperture metalenses and the synchronous rise in design and processing costs. In response to the application requirements of metalens with diameter reaching the order of 10λ or even 10λ, this paper proposes a novel design method for fixed-height concentric-ring metalenses, wherein, under the constraints of the processing technology, a subwavelength 2D building unit library is constructed based on different topological structures, and the overall cross-section of the metalens is assembled.
View Article and Find Full Text PDFSci Bull (Beijing)
December 2024
Frontiers Science Center for Deep Ocean Multispheres and Earth System (FDOMES) and Physical Oceanography Laboratory/Key Laboratory of Ocean Observation and Information of Hainan Province, Sanya Oceanographic Institution, Ocean University of China, Qingdao/Sanya 266000/572000, China; Sanya Oceanographic Laboratory, Sanya 572000, China; Laboratory for Ocean Dynamics and Climate, Qingdao Marine Science and Technology Center, Qingdao 266000, China. Electronic address:
The South China Sea (SCS) is abundant with complex multiscale dynamic processes but their spatiotemporal variations, generation and evolution mechanisms, and mutual interactions remain inadequately understood due to the lack of long-term in situ observations. To explore oceanic multiscale dynamics in the SCS, the SCS Mooring Array (SCSMA) was began to be constructed since 2009. The SCSMA consists of ∼40 moorings and is the largest in situ ocean observing system in marginal seas worldwide.
View Article and Find Full Text PDFIn Vivo
December 2024
Department of Pathology, Korea University Anam Hospital, Korea University College of Medicine, Seoul, Republic of Korea;
Background/aim: Appendiceal neuroendocrine tumors (ANETs) are the most prevalent type of appendiceal neoplasm and the fifth most common neuroendocrine tumor in the gastrointestinal tract. In this study, we described the clinicopathological features of patients with ANET.
Patients And Methods: We reviewed the clinicopathological findings and histopathological reports of six patients diagnosed with ANET between January 2014 and December 2023 at Korea University Medical Center, Anam Hospital.
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