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Basic Science and Pathogenesis.
Alzheimers Dement
December 2024
Interdisciplinary program of cognitive science, Seoul National University College of Humanities, Seoul, Korea, Republic of (South).
Background: Large-scale genome-wide association studies (GWAS) of Alzheimer's disease (AD) from European ancestry identified many genetic variants associated with clinical diagnosis of AD dementia. However, it remains unclear whether these AD-related variants are associated with AD biomarkers, particularly hippocampal atrophy, a well-known neurodegeneration biomarker of AD in a Korean population. In this study, we investigated the association between known AD risk single nucleotide polymorphisms (SNPs) and hippocampal atrophy along the AD continuum in older Korean adults.
View Article and Find Full Text PDFClinical Manifestations.
Alzheimers Dement
December 2024
Neurologia, Azienda Ospedaliero Universitaria di Modena, Modena, Italy.
Background: Recent evidence suggests that unawareness in Alzheimer's disease (AD) continuum can be explained by a failure of the connections between brain regions involved in accessing and monitoring self and other information. It has been demonstrated that AD patients with anosognosia have reduced network connectivity in the default mode network (DMN); in addition, stronger connectivity of bilateral anterior cingulate cortex (ACC) was showed to be associated with anosognosia in prodromal AD suggesting a possible role of this region in mechanisms of "adaptation" to anosognosia early in the disease. Therefore, we hypothesized that anosognosia in AD could be associated with an imbalance between the activity of the DMN and the salience network (SN) detectable using resting state functional magnetic resonance imaging (fMRI).
View Article and Find Full Text PDFClinical Manifestations.
Alzheimers Dement
December 2024
University of Pittsburgh, Pittsburgh, PA, USA.
Background: Recent studies showed that neuroinflammation plays a key role in triggering specific neuropsychiatric symptoms (NPS), such as irritability and agitation, in individuals with Alzheimer's disease (AD). While prior studies showed an association between tau pathology and all NPS domains, the extent to which tau influences each specific NPS domain remains unclear. Here, we aim to investigate the association of tau and NPS domains in the AD continuum.
View Article and Find Full Text PDFClinical Manifestations.
Alzheimers Dement
December 2024
Deparment of Developmental and Educational Psychology, University of Santiago de Compostela, Santiago de Compostela, Spain.
Background: Although there is evidence that measures of verbal fluency, naming and word memory can be good predictors of progression to dementia, language change and the main variables predicting it are not yet fully characterized. Recent research draws attention to the need to consider cognitive reserve, functional, and neurobiological indicators together to explain changes (Facal et al., 2021).
View Article and Find Full Text PDFThe brain's action-mode network.
Nat Rev Neurosci
January 2025
Mallinckrodt Institute of Radiology, Washington University School of Medicine, St. Louis, MO, USA.
The brain is always intrinsically active, using energy at high rates while cycling through global functional modes. Awake brain modes are tied to corresponding behavioural states. During goal-directed behaviour, the brain enters an action-mode of function.
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