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Population pharmacokinetics and pulmonary modeling of eravacycline and the determination of microbiological breakpoint and cutoff of PK/PD.
Antimicrob Agents Chemother
January 2025
Department of Clinical Pharmacy and Pharmacy Administration, School of Pharmacy, Fudan University, Shanghai, China.
Eravacycline is a broad-spectrum fluorocycline currently approved for complicated intra-abdominal infections (cIAIs). In lung-infection models, it is effective against methicillin-resistant (MRSA) and tetracycline-resistant MRSA. As such, we aimed to develop a population pharmacokinetic/pharmacodynamic (PK/PD) model to evaluate eravacycline's pulmonary distribution and kinetics.
View Article and Find Full Text PDFWe investigate the ultrafast electron correlation effects during non-sequential double ionization (NSDI) of argon subjected to a combined femtosecond field composed of counter-rotating two-color circularly polarized (TCCP) pulse laser using a 3D classical ensemble model (CEM). Our simulation results reveal that manipulation of the carrier-envelope phase (CEP) of the external driving field modulates the dynamical behavior of the two electrons, resulting in a notable sensitivity of their momentum distribution to the relative phase of two components of the counter-rotating TCCP field. Through inversion analysis, we uncover the capability to direct electrons toward a single direction, thereby facilitating focused ion-electron collisions on the attosecond timescale.
View Article and Find Full Text PDFThis study investigates the intricate properties of linearly polarized circular Airyprime-Gaussian vortex beams (CApGVBs) in tightly focused optical systems. We explore the relationship between self-focusing and tight focusing of CApGVBs by adjusting the main ring radius. By refining vortex pair parameters, we show that the intensity distribution depends significantly on whether the arrangement is axial or off-axis.
View Article and Find Full Text PDFAn Approach to Fall Detection Using Statistical Distributions of Thermal Signatures Obtained by a Stand-Alone Low-Resolution IR Array Sensor Device.
Sensors (Basel)
January 2025
Faculty of Science and Engineering, Saga University, Saga 840-8502, Japan.
Infrared array sensor-based fall detection and activity recognition systems have gained momentum as promising solutions for enhancing healthcare monitoring and safety in various environments. Unlike camera-based systems, which can be privacy-intrusive, IR array sensors offer a non-invasive, reliable approach for fall detection and activity recognition while preserving privacy. This work proposes a novel method to distinguish between normal motion and fall incidents by analyzing thermal patterns captured by infrared array sensors.
View Article and Find Full Text PDFAnalytical Solutions for Electroosmotic Flow and Heat Transfer Characteristics of Nanofluids in Circular Cylindrical Microchannels with Slip-Dependent Zeta Potential Considering Thermal Radiative Effects.
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January 2025
School of Mechanical Engineering and Rail Transit, Changzhou University, Changzhou 213164, China.
This study analyzes the impact of slip-dependent zeta potential on the heat transfer characteristics of nanofluids in cylindrical microchannels with consideration of thermal radiation effects. An analytical model is developed, accounting for the coupling between surface potential and interfacial slip. The linearized Poisson-Boltzmann equation, along with the momentum and energy conservation equations, is solved analytically to obtain the electrical potential field, velocity field, temperature distribution, and Nusselt number for both slip-dependent (SD) and slip-independent (SI) zeta potentials.
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