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Safety and Short-term Efficacy of a Single Dose of 2 mg Moxidectin in -Infected Individuals: A Double-Blind, Randomized Ivermectin-Controlled Trial With Ascending Microfilarial Densities.
Open Forum Infect Dis
July 2024
TransVIHMI, Université de Montpellier, Inserm Unité 1175, Institut de Recherche pour le Développement, Montpellier, France.
Background: In 2018, the US Food and Drug Administration approved the macrocylic lactone moxidectin (MOX) at 8 mg dosage for onchocerciasis treatment in individuals aged ≥12 years. Severe adverse reactions have occurred after ivermectin (IVM), also a macrocyclic lactone, in individuals with high microfilarial density (MFD). This study compared the safety and efficacy of a 2 mg MOX dose and the standard 150 µg/kg IVM dose in individuals with low MFD.
View Article and Find Full Text PDFFirst Measurement Using Elliptically Polarized Photons of the Double-Polarization Observable E for γp→pπ^{0} and γp→nπ^{+}.
Phys Rev Lett
March 2024
Department of Physics, University of York, Heslington, York, Y010 5DD, United Kingdom.
We report the measurement of the helicity asymmetry E for the pπ^{0} and nπ^{+} final states using, for the first time, an elliptically polarized photon beam in combination with a longitudinally polarized target at the Crystal Ball experiment at MAMI. The results agree very well with data that were taken with a circularly polarized photon beam, showing that it is possible to simultaneously measure polarization observables that require linearly (e.g.
View Article and Find Full Text PDFComparative Performance Evaluation of Double-Stranded RNA High-Throughput Sequencing for the Detection of Viral Infection in Temperate Fruit Crops.
Phytopathology
July 2024
INRAE, Univ. Bordeaux, UMR Biologie du fruit et Pathologie, CS20032, 33882 Villenave d'Ornon Cedex, France.
There is limited information on the compared performances of biological, serological. and molecular assays with high-throughput sequencing (HTS) for viral indexing in temperate fruit crops. Here, using a range of samples of predetermined virological status, we compared two performance criteria (inclusivity and analytical sensitivity) of enzyme-linked immunosorbent assay (ELISA), molecular hybridization, reverse transcription (RT)-PCR, and double-stranded RNA (dsRNA) HTS for the detection of a total of 14 viruses (10 genera) and four viroids (three genera).
View Article and Find Full Text PDFMagnetic Response of Nematic Superconductors: Skyrmion Stripes and Their Signatures in Muon Spin Relaxation Experiments.
Phys Rev Lett
June 2023
Department of Physics, KTH-Royal Institute of Technology, Stockholm, SE-10691 Sweden.
We investigate the magnetic response of nematic superconductors, presenting a new approach to find vortex and skyrmion structures beyond symmetry-constraining Ansätze. Using this approach we show that nematic superconductors form distinctive skyrmion stripes. Our approach lends itself to accurate determination of the field distribution for muon spin rotation probes.
View Article and Find Full Text PDFStudy of nuclear modification factors of deuteron and anti-deuteron in Pb-Pb collisions at [Formula: see text].
Sci Rep
February 2022
China Institute of Atomic Energy, P.O. Box 275(10), Beijing, 102413 China.
The nuclear modification factors ([Formula: see text]) of d and [Formula: see text] have been studied using the parton and hadron cascade model plus the dynamically constrained phase space coalescence model in peripheral (40-60%) and central (0-5%) Pb-Pb collisions at [Formula: see text] with [Formula: see text]. It is found that the [Formula: see text] of [Formula: see text] is similar to that of hadrons ([Formula: see text]) and the [Formula: see text] of antiparticles is the same as that of particles. The suppression effect of d is more significant than that of baryons and mesons in the high-[Formula: see text] region.
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