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Enhanced co-expression of TIGIT and PD-1 on γδ T cells correlates with clinical features and laboratory parameters in patients with primary Sjögren's syndrome.
Clin Rheumatol
January 2025
Jiangsu Institute of Clinical Immunology, the First Affiliated Hospital of Soochow University, Suzhou, 215021, China.
Objectives: The research aimed to assess the proportions of Gamma delta (γδ) T cells and the expression levels of CD226, ICOS, CD40L, OX40, TIGIT, LAG-3, Tim-3, and PD-1 on γδ T cells in the peripheral blood of patients diagnosed with primary Sjögren's syndrome (pSS), and to evaluate the clinical significance of these findings.
Methods: Utilizing flow cytometry, we investigated the proportion of γδ T cells and the expression of CD226, ICOS, CD40L, OX40, TIGIT, LAG-3, PD-1, and Tim-3 on γδ T cells in 37 patients diagnosed with pSS and 28 healthy controls (HC). Moreover, we explored the potential associations between the proportion of γδ T cells, TIGIT + γδ T cells, PD-1 + γδ T cells, and TIGIT + PD-1 + γδ T cells with clinical symptoms and laboratory parameters.
Reduced UPF1 levels in senescence impair nonsense-mediated mRNA decay.
Commun Biol
January 2025
Department of Biological Sciences, Chungnam National University, Daejeon, 34134, Republic of Korea.
Cells regulate gene expression through various RNA regulatory mechanisms, and this regulation often becomes less efficient with age, contributing to accelerated aging and various age-related diseases. Nonsense-mediated mRNA decay (NMD), a well-characterized RNA surveillance mechanism, degrades aberrant mRNAs with premature termination codons (PTCs) to prevent the synthesis of truncated proteins. While the role of NMD in cancer and developmental and genetic diseases is well documented, its implications in human aging remain largely unexplored.
View Article and Find Full Text PDFShielding design and heat transfer analysis of the transportation container of a hot batch in the Mo production facility.
Appl Radiat Isot
January 2025
Nuclear Science and Technology Research Institute (NSTRI), P.O. Box: 14155-1339, Tehran, Iran.
In molybdenum-99 (Mo) production facilities via the fission method, appropriate transportation containers must be used to transfer irradiated targets from the irradiation facility to the processing facility, following the requirements for transferring radioactive materials. In the Mo production industrial plan of Iran, the transportation container must be capable of carrying a holster containing nine irradiated low-enriched uranium targets, known as a hot batch. In this article, the proper shielding of two-layer containers based on the gamma spectrum emitted from the radioisotope inventory of a local hot batch, including fission products, activation products, and other radioisotopes produced from their decay chains, was investigated by using Monte Carlo code MCNP6.
View Article and Find Full Text PDFMulti-layer shielding optimization of a high activity Am-Be mixed field irradiation facility.
Appl Radiat Isot
March 2025
Experimental Nuclear Physics Department, Nuclear Research Centre, Egyptian Atomic Energy Authority, Egypt; Cyclotron Facility, Egyptian Atomic Energy Authority, Egypt.
Neutron and gamma-ray shielding design for a 30Ci (1.11TBq) Am-Be irradiation facility is studied using MCNP5 Monte Carlo simulation code. The study focuses on the optimization of the shielding layers of the previously planned neutron irradiation facility.
View Article and Find Full Text PDFImproved analysis of supervised learning in the RKHS with random features: Beyond least squares.
Neural Netw
January 2025
City University of Hong Kong Shenzhen Research Institute, Shenzhen, China; Department of Mathematics, City University of Hong Kong, Hong Kong, China. Electronic address:
We consider kernel-based supervised learning using random Fourier features, focusing on its statistical error bounds and generalization properties with general loss functions. Beyond the least squares loss, existing results only demonstrate worst-case analysis with rate n and the number of features at least comparable to n, and refined-case analysis where it can achieve almost n rate when the kernel's eigenvalue decay is exponential and the number of features is again at least comparable to n. For the least squares loss, the results are much richer and the optimal rates can be achieved under the source and capacity assumptions, with the number of features smaller than n.
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