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Relationship Among Macronutrients, Dietary Components, and Objective Sleep Variables Measured by Smartphone Apps: Real-World Cross-Sectional Study.
J Med Internet Res
January 2025
International Institute for Integrative Sleep Medicine (WPI-IIIS), University of Tsukuba, Tsukuba, Ibaraki, Japan.
Background: Few studies have explored the relationship between macronutrient intake and sleep outcomes using daily data from mobile apps.
Objective: This cross-sectional study aimed to examine the associations between macronutrients, dietary components, and sleep parameters, considering their interdependencies.
Methods: We analyzed data from 4825 users of the Pokémon Sleep and Asken smartphone apps, each used for at least 7 days to record objective sleep parameters and dietary components, respectively.
Design of a light and Ca switchable organic-peptide hybrid.
Proc Natl Acad Sci U S A
February 2025
SKKU Advanced Institute of Nanotechnology (SAINT), Sungkyunkwan University, Suwon 16419, Republic of Korea.
The design of organic-peptide hybrids has the potential to combine our vast knowledge of protein design with small molecule engineering to create hybrid structures with complex functions. Here, we describe the computational design of a photoswitchable Ca-binding organic-peptide hybrid. The designed molecule, designated Ca-binding switch (CaBS), combines an EF-hand motif from classical Ca-binding proteins such as calmodulin with a photoswitchable group that can be reversibly isomerized between a spiropyran (SP) and merocyanine (MC) state in response to different wavelengths of light.
View Article and Find Full Text PDFImpaired spatial coding of the hippocampus in a dentate gyrus hypoplasia mouse model.
Proc Natl Acad Sci U S A
February 2025
Zanvyl Krieger Mind/Brain Institute, Johns Hopkins University, Baltimore, MD 21218.
The hippocampal dentate gyrus (DG) is thought to orthogonalize inputs from the entorhinal cortex (pattern separation) and relay this information to the CA3 region. In turn, attractor dynamics in CA3 perform a pattern completion or error correction operation before sending its output to CA1. In a mouse model of congenital hypoplasia of the DG, a deficiency in the (Wls) gene, specifically in cells expressing , which targets neuronal progenitors, led to an almost total absence of dentate granule cells and modestly impaired performance in spatial tasks.
View Article and Find Full Text PDFOptimal strategies for correcting merotelic chromosome attachments in anaphase.
Proc Natl Acad Sci U S A
February 2025
Courant Institute for Mathematical Sciences and Department of Biology, New York University, New York, NY 10012.
Accurate chromosome segregation in mitosis depends on proper connections of sister chromatids, through microtubules, to the opposite poles of the early mitotic spindle. Transiently, many inaccurate connections are formed and rapidly corrected throughout the mitotic stages, but a small number of merotelic connections, in which a chromatid is connected to both spindle poles, remain lagging at the spindle's equator in anaphase. Most of the lagging chromatids are eventually moved to one or the other pole, likely by a combination of microtubules' turnover and the brute force of pulling by the microtubules' majority from the one pole against the microtubules' minority from the other pole.
View Article and Find Full Text PDFEnergetic constraints drive the decline of a sentinel polar bear population.
Science
January 2025
Laboratory of Quantitative Global Change Ecology, Department of Biological Sciences, University of Toronto Scarborough, Toronto, ON, Canada.
Human-driven Arctic warming and resulting sea ice loss have been associated with declines in several polar bear populations. However, quantifying how individual responses to environmental change integrate and scale to influence population dynamics in polar bears has yet to be achieved. We developed an individual-based bioenergetic model and hindcast population dynamics across 42 years of observed sea ice conditions in Western Hudson Bay, a region undergoing rapid environmental change.
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