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Olanzapine/Samidorphan Effects on Weight Gain: An Individual Patient Data Meta-Analysis of Phase 2 and 3 Randomized Double-Blind Studies.
J Clin Psychiatry
January 2025
Division of Pharmacotherapy and Translational Science, College of Pharmacy, University of Texas at Austin, San Antonio, Texas.
To evaluate weight change with a combination of olanzapine and samidorphan (OLZ/SAM) versus olanzapine by pooling data across clinical studies. This study was an individual patient data (IPD) meta-analysis of clinical trial data. EMBASE, MEDLINE, and PsycInfo were searched for randomized clinical trials (≥12 weeks) in adults with schizophrenia or bipolar I disorder in which weight change from baseline was the primary or secondary end point.
View Article and Find Full Text PDFNurse-Led/Involved Home-Based Interventions for Older Adults With Chronic Obstructive Pulmonary Disease (COPD): A Mixed-Methods Systematic Review.
J Clin Nurs
January 2025
School of Nursing and Midwifery College of Health, Medicine, and Wellbeing Hunter and Medical Research Institute Healthcare Transformation Research Program, The Centre for Transformative Nursing, Midwifery, and Health Research, Hunter New England Local Health District, University of Newcastle, Newcastle, New South Wales, Australia.
Aims: To determine the effectiveness of nurse-led/involved home-based interventions for older people with COPD and to explore the experiences of older people and nurses with the interventions.
Design: A mixed-methods systematic review following the JBI methodology for mixed-methods systematic reviews.
Data Sources: The search included relevant and peer-reviewed studies published from January 2010 to December 2023 in CINAHL, MEDLINE, Cochrane Central Register of Controlled Trials, PsycINFO, EMBASE, JBI, EMCARE and ProQuest.
Prevalence of Vitamin D deficiency among individuals with Fontan palliation: A systematic review and meta-analysis.
Ann Pediatr Cardiol
December 2024
Postgraduate School of Public Health, Universitas Muhammadiyah Aceh, Banda Aceh, Indonesia.
Background: Children with one functional ventricle might receive the Fontan procedure as palliative management to prolong their lives. However, the heart remains functionally univentricular, which may result in disrupted absorption of nutrients, including Vitamin D. Individuals with Fontan circulation have limited physical activity and sun exposure, which might further contribute to Vitamin D deficiency.
View Article and Find Full Text PDFEffects of converting cropland to grassland on greenhouse gas emissions from peat and organic-rich soils in temperate and boreal climates: a systematic review.
Environ Evid
January 2025
Department of Soil and Environment, Swedish University of Agricultural Sciences, Box 7014, 750 07, Uppsala, Sweden.
Background: To align with climate goals, greenhouse gas (GHG) emissions from agriculture must be reduced significantly. Cultivated peatlands are an important source of such emissions. One proposed measure is to convert arable fields on peatlands to grassland, as the Intergovernmental Panel on Climate Change (IPCC) default emission factors (EF) for organic soils are lower from grasslands.
View Article and Find Full Text PDFSystematic Review and Meta-Analysis: The Association Between Newer Generation Antidepressants and Insomnia in Children and Adolescents With Major Depressive Disorder.
J Am Acad Child Adolesc Psychiatry
January 2025
University Medical Center Groningen, Groningen, The Netherlands.
Objective: To examine the association between newer generation antidepressants and insomnia as an adverse event (AE) in the treatment of children and adolescents with major depressive disorder (MDD).
Method: A systematic search was performed in major databases (inception to August 31, 2023) to retrieve double-blind, placebo-controlled, randomized controlled trials (RCTs) evaluating the safety of 19 antidepressants in the acute treatment (initial 6 to 12 weeks) of children and adolescents aged ≤ 18 years with MDD (primary analyses). RCTs in anxiety disorders and obsessive-compulsive disorder (OCD) were retrieved from a recent meta-analysis and included in complementary analyses.
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