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Laboratory of Immunology and Inflammation, School of Life Sciences and Biopharmaceutics, Guangdong Pharmaceutical University, Guangzhou, China.
Renal fibrosis is the most common pathway for the development of end-stage renal disease (ESRD) in various kidney diseases. Currently, the treatment options for renal fibrosis are limited. Ferroptosis is iron-mediated lipid peroxidation, triggered mainly by iron deposition and ROS generation.
View Article and Find Full Text PDFHigh heterogeneity in the size distribution of the micellar fraction from in vitro digestions: sample preparation and reporting recommendations.
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Department of Food Technology, Fulda University of Applied Sciences, Fulda, Germany.
Background: Understanding the size and surface charge (ζ-potential) of particles in the mixed micellar fraction produced by in vitro digestion is crucial to understand their cellular absorption and transport. The inconsistent presentation of micellar size data, often limited to average particle diameter, makes comparison of studies difficult. The present study aimed to assess different size data representations (mean particle diameter, relative intensity- or volume-weighted size distribution) to better understand physiological mixed micelle characteristics and to provide recommendations for size reporting and sample handling.
View Article and Find Full Text PDFThe role of avocado plant and its derivatives in the management of diabetes mellitus: a natural approach to glycemic control.
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Purpose: Diabetes mellitus is a global health challenge that leads to severe complications, negatively impacting overall health, life expectancy, and quality of life. Herbal medicines, valued for their accessibility and therapeutic benefits with minimal side effects, have been promoted as potential treatments. Managing conditions like diabetes, characterized by free radical production and cytokine-driven inflammation, is vital due to the active components in plants that exert direct pharmacological effects.
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View Article and Find Full Text PDFBackground: Bispecific T cell-engagers (BTEs) are engineered antibodies that redirect T cells to target antigen-expressing tumors. BTEs targeting various tumor-specific antigens, like interleukin 13 receptor alpha 2 (IL13RA2) and EGFRvIII, have been developed for glioblastoma (GBM). However, limited knowledge of BTE actions derived from studies conducted in immunocompromised animal models impedes progress in the field.
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