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Spine-Abductor Syndrome: Novel Associations Between Lumbar Spine Disease and Hip Gluteal Muscle Pathology.
J Bone Joint Surg Am
November 2024
Department of Orthopaedic Surgery, Cleveland Clinic Foundation, Cleveland, Ohio.
Background: Risk factors for gluteal tears include age-related deterioration, female sex, and increased body mass index. As the literature that supports the sagittal relationship between the lumbar spine and the hip is increasing, there may be a parallel relationship between the perturbations in spinopelvic alignment caused by lumbar spine disease and gluteal muscle tears. Because no prior studies other than single-institution series have reported on this phenomenon, we investigated spine-abductor syndrome at the population level.
View Article and Find Full Text PDFA STING-CASM-GABARAP pathway activates LRRK2 at lysosomes.
J Cell Biol
February 2025
Department of Cell Biology, Yale University School of Medicine, New Haven, CT, USA.
Mutations that increase LRRK2 kinase activity have been linked to Parkinson's disease and Crohn's disease. LRRK2 is also activated by lysosome damage. However, the endogenous cellular mechanisms that control LRRK2 kinase activity are not well understood.
View Article and Find Full Text PDFPeripheral blood immune cells from individuals with Parkinson's disease or inflammatory bowel disease share deficits in iron storage and transport that are modulated by non-steroidal anti-inflammatory drugs.
Neurobiol Dis
January 2025
Center for Translational Research in Neurodegenerative Disease, College of Medicine, University of Florida, Gainesville, FL, USA; Department of Neuroscience, College of Medicine, University of Florida, Gainesville, FL, USA; McKnight Brain Institute, University of Florida, Gainesville, FL, USA; Aligning Science Across Parkinson's (ASAP) Collaborative Research Network, Chevy Chase, MD, USA; Norman Fixel Institute for Neurological Diseases, University of Florida, Gainesville, FL, USA. Electronic address:
Parkinson's Disease (PD) is a multisystem disorder in which dysregulated neuroimmune crosstalk and inflammatory relay via the gut-blood-brain axis have been implicated in PD pathogenesis. Although alterations in circulating inflammatory cytokines and reactive oxygen species (ROS) have been associated with PD, no biomarkers have been identified that predict clinical progression or disease outcome. Gastrointestinal (GI) dysfunction, which involves perturbation of the underlying immune system, is an early and often-overlooked symptom that affects up to 80 % of individuals living with PD.
View Article and Find Full Text PDFLearning with noisy labels via clean aware sharpness aware minimization.
Sci Rep
January 2025
School of Mechanical, Electrical, and Information Engineering, Putian University, Putian, 351100, China.
Noise label learning has attracted considerable attention owing to its ability to leverage large amounts of inexpensive and imprecise data. Sharpness aware minimization (SAM) has shown effective improvements in the generalization performance in the presence of noisy labels by introducing adversarial weight perturbations in the model parameter space. However, our experimental observations have shown that the SAM generalization bottleneck primarily stems from the difficulty of finding the correct adversarial perturbation amidst the noisy data.
View Article and Find Full Text PDFInteracting Dark Energy after DESI Baryon Acoustic Oscillation Measurements.
Phys Rev Lett
December 2024
School of Mathematics and Statistics, University of Sheffield, Hounsfield Road, Sheffield S3 7RH, United Kingdom.
Article Synopsis
- The study examines how baryon acoustic oscillations data from the Dark Energy Spectroscopic Instrument affects interacting dark energy (IDE) models, which suggest an energy transfer between dark matter and dark energy.
- By integrating data from Planck-2018 and the Dark Energy Spectroscopic Instrument, researchers find a noticeable preference for interactions, leading to a present-day expansion rate that alleviates existing tensions with other measurements.
- Although the IDE model offers a compelling explanation for various observational data and presents compatible expansion rates, it does struggle with predictions related to the overall matter density and large-scale structures in the universe.
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