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Experiences of Family Members and Patients with Spinal Muscular Atrophy Under the Multi-Level Medical Security System in Shanxi Province, China: A Mixed Study.
Healthcare (Basel)
January 2025
Department of Pharmacy Administration and Clinical Pharmacy, School of Pharmacy, Xi'an Jiaotong University, 76 Yanta West Road, Xi'an 710061, China.
Spinal muscular atrophy is a rare genetic disease. Nusinersen and Risdiplam, recognized as disease-modifying therapies, were included in the National Reimbursement Drug List in 2022 and 2023, respectively, in China. Policies have been implemented to enhance a multi-level medical security system, particularly for rare diseases.
View Article and Find Full Text PDFMulti-assay assessment of cytotoxicity reveals multiple mechanisms of action in 3D microtissues.
Sci Rep
January 2025
School of Engineering, Brown University, Providence, RI, USA.
Cell viability assays are an integral component of toxicology and high-throughput drug screening studies; however, many assays rely on a single biomarker of cell death which provides an incomplete assessment of cell viability. Here, we introduce an innovative approach that combines data from multiple assays using a linear mixed effects regression model and principal component analysis. We explored the cytotoxic response of various assay-treatment combinations using four assays with distinct mechanisms of action and seven different treatments across three types of microtissue cultures.
View Article and Find Full Text PDFObstetric danger signs in context: A mixed methods study exploring knowledge and sociocultural factors among pregnant women.
J Educ Health Promot
December 2024
Department of Community Medicine, Shri M. P. Shah Government Medical College, Jamnagar, Gujarat, India.
Background: Maternal morbidity and mortality persist due to delays in seeking care for obstetric complications. Deficits in comprehending danger signs contribute to preventing early identification. There is limited research on awareness levels among rural Indian women.
View Article and Find Full Text PDFMixed lipopeptide-based mucosal vaccine candidate induces cross-variant immunity and protects against SARS-CoV-2 infection in hamsters.
Immunohorizons
January 2025
Department of Surgery, Faculty of Medicine and Dentistry, College of Health Sciences, University of Alberta, Edmonton, AB, Canada.
The global dissemination of SARS-CoV-2 led to a worldwide pandemic in March 2020. Even after the official downgrading of the COVID-19 pandemic, infection with SARS-CoV-2 variants continues. The rapid development and deployment of SARS-CoV-2 vaccines helped to mitigate the pandemic to a great extent.
View Article and Find Full Text PDFMultiple Imputation for Longitudinal Data: A Tutorial.
Stat Med
February 2025
Clinical Epidemiology & Biostatistics (CEBU), Murdoch Children's Research Institute, Parkville, Australia.
Longitudinal studies are frequently used in medical research and involve collecting repeated measures on individuals over time. Observations from the same individual are invariably correlated and thus an analytic approach that accounts for this clustering by individual is required. While almost all research suffers from missing data, this can be particularly problematic in longitudinal studies as participation often becomes harder to maintain over time.
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