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Towards precise LET measurements based on energy deposition of therapeutic ions in Timepix3 detectors.
Phys Med Biol
June 2024
Heidelberg Institute for Radiation Oncology (HIRO), National Center for Research in Radiation Oncology (NCRO), Im Neuenheimer Feld 280, 69120 Heidelberg, Germany.
There is an increasing interest in calculating and measuring linear energy transfer (LET) spectra in particle therapy in order to assess their impact in biological terms. As such, the accuracy of the particle fluence energy spectra becomes paramount. This study focuses on quantifying energy depositions of distinct proton, helium, carbon, and oxygen ion beams using a silicon pixel detector developed at CERN to determine LET spectra in silicon.
View Article and Find Full Text PDFStudy of the intracellular nanoparticle-based radiosensitization mechanisms in F98 glioma cells treated with charged particle therapy through synchrotron-based infrared microspectroscopy.
Analyst
March 2020
MIRAS beamline BL01, ALBA-CELLS Synchrotron, Carrer de la Llum 2-26, 08290 Cerdanyola del Vallès, Spain.
The use of nanoparticles (NP) as dose enhancers in radiotherapy (RT) is a growing research field. Recently, the use of NP has been extended to charged particle therapy in order to improve the performance in radioresistant tumors. However, the biological mechanisms underlying the synergistic effects involved in NP-RT approaches are not clearly understood.
View Article and Find Full Text PDFNext generation multi-scale biophysical characterization of high precision cancer particle radiotherapy using clinical proton, helium-, carbon- and oxygen ion beams.
Oncotarget
August 2016
German Cancer Consortium (DKTK), Translational Radiation Oncology, National Center for Tumor Diseases (NCT), German Cancer Research Center (DKFZ), Heidelberg, Germany.
The growing number of particle therapy facilities worldwide landmarks a novel era of precision oncology. Implementation of robust biophysical readouts is urgently needed to assess the efficacy of different radiation qualities. This is the first report on biophysical evaluation of Monte Carlo simulated predictive models of prescribed dose for four particle qualities i.
View Article and Find Full Text PDFQuantification of the relative biological effectiveness for ion beam radiotherapy: direct experimental comparison of proton and carbon ion beams and a novel approach for treatment planning.
Int J Radiat Oncol Biol Phys
November 2010
Department of Biophysics, GSI Helmholtz Centre for Heavy Ion Research, Darmstadt, Germany.
Purpose: To present the first direct experimental in vitro comparison of the biological effectiveness of range-equivalent protons and carbon ion beams for Chinese hamster ovary cells exposed in a three-dimensional phantom using a pencil beam scanning technique and to compare the experimental data with a novel biophysical model.
Methods And Materials: Cell survival was measured in the phantom after irradiation with two opposing fields, thus mimicking the typical patient treatment scenario. The novel biophysical model represents a substantial extension of the local effect model, previously used for treatment planning in carbon ion therapy for more than 400 patients, and potentially can be used to predict effectiveness of all ion species relevant for radiotherapy.
The four-particle process of proton-helium transfer ionization has been studied using cold target recoil ion momentum spectroscopy to measure the momenta of all three particles in the final state. Most of the electrons are emitted in the H0 scattering plane and in the backward direction. The final state momentum distributions show discrete structures very different from those expected for uncorrelated capture and ionization.
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