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An accelerator-based neutron source design with a thermal neutron port and an epithermal neutron port for boron neutron capture therapy.
Appl Radiat Isot
December 2024
Institute of Nuclear Techniques of Budapest University of Technology and Economics, Műegyetem Rkp 9, 1111, Budapest, Hungary.
This study presents a compact accelerator-driven neutron source design with a thermal neutron port and an epithermal neutron port for Boron Neutron Capture Therapy (BNCT), based on 10 mA 2.5 MeV protons bombarding on a 100 μm thick disc-shaped Li target with a diameter of 10 cm. The moderator consists of 2 parts, the epithermal neutron moderator and the thermal neutron moderator.
View Article and Find Full Text PDFCharacterization of acrylic phantom for use in quality assurance of BNCT beam output procedure.
J Radiat Res
November 2024
Particle Radiation Oncology Research Center, Institute for Integrated Radiation and Nuclear Science, Kyoto University, 2, Asashiro-Nishi, Kumatori-cho, Sennan-gun, Osaka 590-0494, Japan.
The accelerator-based boron neutron capture therapy (BNCT) system has been approved for specific cases covered by health insurance, and clinical trials for new cases in Japan are currently being conducted on other systems. Owing to the progress of accelerator-based BNCT, the operation of medical physics must be rendered more efficient. A water phantom is used for the quality assurance (QA) of the BNCT beam output procedure; however, a solid phantom is preferred for routine QA because of its ease of use.
View Article and Find Full Text PDFTherapeutic Effect of Boron Neutron Capture Therapy on Boronophenylalanine Administration via Cerebrospinal Fluid Circulation in Glioma Rat Models.
Cells
September 2024
Institute for Integrated Radiation and Nuclear Science, Kyoto University, 2 Asashiro-Nishi, Kumatori-cho, Sennan-gun 590-0494, Japan.
Article Synopsis
- Recent advancements in drug delivery systems aim to improve brain tumor treatment by bypassing the blood-brain barrier, particularly using cerebrospinal fluid (CSF) for boron neutron capture therapy (BNCT).
- A study conducted at Kyoto University evaluated the effectiveness of BPA delivery via CSF in glioma model rats, comparing it to traditional intravenous (IV) administration.
- Results showed that CSF administration led to comparable tumor treatment efficacy while reducing BPA accumulation in normal tissues and maintaining better overall health in the treated rats.
Molecular Probe with Potential for Combined Boron Neutron Capture and Photothermal Antitumor Therapy.
ACS Appl Bio Mater
September 2024
College of Engineering and Applied Sciences, Nanjing University, Nanjing 210023, China.
Both boron neutron capture therapy (BNCT) and photothermal therapy (PTT) have been applied to tumor treatment in clinical. However, their therapeutic efficacy is limited. For BNCT, the agents not only exhibit poor targeting ability but also permit only a single irradiation session within a course due to significant radiation risks.
View Article and Find Full Text PDFCompelling DNA intercalation through 'anion-anion' anti-coulombic interactions: boron cluster self-vehicles as promising anticancer agents.
J Mater Chem B
October 2024
Institut de Ciència de Materials de Barcelona (C.S.I.C.) Campus U.A.B, 08193 Bellaterra, Barcelona, Spain.
Anticancer drugs inhibit DNA replication by intercalating between DNA base pairs, forming covalent bonds with nucleotide bases, or binding to the DNA groove. To develop safer drugs, novel molecular structures with alternative binding mechanisms are essential. Stable boron hydrides offer a promising alternative for cancer therapy, opening up additional options like boron neutron capture therapy based on B and thermal neutron beams or proton boron fusion therapy using B and proton beams.
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