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Development and evaluation of chitosan-coated virgin coconut oil-asiatic acid-loaded nanoemulgel for enhanced wound management.
Int J Biol Macromol
January 2025
Department of Pharmaceutics and Industrial Pharmacy, Pharm D Program, Egypt-Japan University of Science and Technology (E-JUST), Alexandria, Egypt.
Wound management remains a significant challenge due to complications such as delayed healing and microbial infections, particularly in the conditions like diabetes mellitus, vascular disorders, and immunosuppression. This study aimed to develop a chitosan-coated virgin coconut oil-asiatic acid-loaded nanoemulsion gel (CS-ASA-NEG) to enhance wound healing outcomes. A central composite design (CCD) was employed using Design Expert 11 software to optimize the nanoemulsion formulation, with ternary phase diagrams (TPD) evaluating stable regions for Tween 20: Span 80 (T20:S80) ratios.
View Article and Find Full Text PDFTherapeutic Bioactivities and Chemical Composition Analysis of Rhizome Oleoresin of Hedychium coronarium Collected from Uttarakhand, India.
Comb Chem High Throughput Screen
January 2025
School of Pharmacy, D.Y. Patil University (Deemed to be University), Sector 7, Nerul, Navi Mumbai 400706, India.
Introduction: Hedychium coronarium J. König, from the Zingiberaceae family, is a rhizomatous herb used in Ayurvedic medicine for its febrifuge, anti-rheumatic, and anthelmintic properties.
Method: This study characterizes the chemical diversity and biological activities of H.
Ultrafast Detection of ppb-Level NH Gas at Room Temperature Using CuO Nanoparticles Decorated AlN-Based Surface Acoustic Wave Sensor.
ACS Sens
January 2025
Department of Physics, Chungnam National University, 99 Daehak-road, Yuseong-gu, Daejeon 34134, Republic of Korea.
Rational design of heterostructure (HS)-based surface acoustic wave (SAW) smart gas sensors for efficient and accurate subppm level ammonia (NH) detection at room temperature (RT) is of great significance in environmental protection and human safety. This study introduced a novel HS composed of an AlN-based SAW resonator and CuO nanoparticles (NPs) as a chemical interface for NH detection at RT (∼26 °C). The structural, morphological, and chemical compositions were detailly investigated, which demonstrates that the CuO/AlN HS was successfully formed via interfacial modulation.
View Article and Find Full Text PDFMolecular dynamics simulation dataset for SiO-BO-(1--)NaO glasses.
Data Brief
February 2025
Université Paris-Saclay, CEA, CNRS, SPEC, 91191 Gif-sur-Yvette, France.
Silicate glasses are commonly used for many important industrial applications. As such, the literature provides a wealth of different structural, physical, thermodynamic and mechanical properties for many different chemical compositions of oxide glasses. However, a frequent limitation to existing datasets is that only one or two material properties can be evaluated for a given sample.
View Article and Find Full Text PDFDesign, Preparation, and Ex Vivo Skin Permeation of Doxepin Microemulsion System for Topical Delivery.
J Cosmet Dermatol
January 2025
Department of Pharmaceutics, Faculty of Pharmacy, Ahvaz Jundishapur University of Medical Sciences, Ahvaz, Iran.
Background: Doxepin (DX) is used orally to relieve itching but can cause side effects like blurred vision, dry mouth, and drowsiness due to its antimuscarinic effect. To reduce these adverse effects and improve skin permeation, DX is being developed in topical formulations. This study aims to improve DX skin absorption by developing a microemulsion (ME) formulation (ME-DX).
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