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Effect of 4-methylbenzoquinone concentration on its covalent conjugates with β-lactoglobulin: Structural and functional properties.
Food Chem
March 2025
Engineering Research Center of Health Food Design & Nutrition Regulation, Dongguan Key Laboratory of Typical Food Precision Design, China National Light Industry Key Laboratory of Healthy Food Development and Nutrition Regulation, School of Life and Health Technology, Dongguan University of Technology, Dongguan 523808, China.
This study examined the effect of quinone concentration on covalent interaction between β-lactoglobulin (β-Lg) and 4-methylbenzoquinone (4MBQ). β-Lg-4MBQ-0.2, β-Lg-4MBQ-0.
View Article and Find Full Text PDFSarcopenia may increase cisplatin toxicity in bladder cancer patients with borderline renal function.
BJU Int
December 2024
Department of Urology, Glickman Urological and Kidney Institute, Cleveland Clinic, Cleveland, OH, USA.
Objectives: To assess whether the effect of sarcopenia on neoadjuvant chemotherapy (NAC) toxicity is modified by borderline renal function (estimated glomerular filtration rate [eGFR] 40-65 mL/min) and whether sarcopenia and borderline renal function are independently associated with NAC toxicity risk.
Patients And Methods: All patients with muscle-invasive bladder cancer (MIBC) who underwent radical cystectomy (RC) between 2010 and 2022, with available cross-sectional imaging prior to NAC initiation, were included. Skeletal mass was measured from axial computed tomography images obtained at the level of the L3 vertebral body, using Aquarius Intuition software.
Multi-method coamorphous systems of lumefantrine with alpha ketoglutaric acid: Comprehensive characterization, biological evaluation and stability analysis.
Int J Pharm
January 2025
Department of Pharmaceutical Analysis, National Institute of Pharmaceutical Education and Research (NIPER), Hyderabad, Telangana 500037, India. Electronic address:
Article Synopsis
- Researchers developed coamorphous systems (CAM) using lumefantrine (LMF) and alpha-ketoglutaric acid (KGA) to improve LMF's solubility and bioavailability through three distinct methods: liquid-assisted grinding, solvent evaporation, and quench-cooling.
- Testing via PXRD, DSC, and other techniques confirmed the successful amorphization and intermolecular interactions in these CAMs, along with simulations showing diverse molecular environments.
- The new CAMs significantly enhanced solubility (up to 14.73x), dissolution rates (up to 2.63x), and pharmacokinetics in living organisms (up to 10.86x), while also demonstrating anti-cancer
The ZJU index is associated with the risk of sarcopenia in American adults aged 20-59: a cross-sectional study.
Lipids Health Dis
November 2024
Gastric Cancer Center, West China Hospital, Sichuan University, Chengdu, Sichuan, China.
Background: The ZJU index is an innovative computational method which integrates BMI, FBG, TG, and ALT to AST ratio. It strongly correlates with measures of lipid metabolism and glucose intolerance. No researches have yet explored the relationship between the ZJU index and sarcopenia.
View Article and Find Full Text PDFBiochar-based metal tolerating plant growth promoting bacterial inoculants enhanced the ability of ryegrass for phytostabilization.
Environ Res
January 2025
School of Environmental Science and Engineering, Changzhou University, Changzhou, 213164, China.
Metal-tolerant microbes with plant growth-promoting traits represent a promising biological amendment for enhancing the phytostabilization of contaminated soils. However, the relationship between phytostabilization efficiency and microbial consortium composition and diversity remains unclear. This study selected three cadmium (Cd) resistant plant growth promoting bacteria (PGPB) from Bacillus, Pseudomonas, and Rhodopseudomonas were selected as candidates for biochar-based microbial inoculants.
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