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Since its introduction, vaccination has heavily improved health outcomes. However, implementing vaccination efforts can be challenging, particularly in low and middle-income countries with warmer climates. Microneedle technology has been developed for its simple and relatively painless applications of vaccines.
View Article and Find Full Text PDFResponse and variation mechanisms of RDX crystals under strong magnetic loading.
RSC Adv
January 2025
The Second Department, Xi' an Modern Chemistry Research Institute Xi'an 710065 China
To fully understand the variation in performance of cyclotrimethylenetrinitramine (RDX) crystals under strong magnetic field exposure, the strong magnetic loading of RDX was conducted in both stable and alternating magnetic fields. The morphological changes of RDX crystals exposed to magnetic fields were studied under a scanning electron microscope. Then, the lattice changes of RDX exposed to magnetic fields were analyzed through X-ray diffraction and Raman spectroscopy.
View Article and Find Full Text PDFVisible Light Spectroscopy of Liquid Solutes from Femto- to Attoliter Volumes Inside a Single Nanofluidic Channel.
ACS Nano
January 2025
Department of Physics, Chalmers University of Technology, SE-412 96 Gothenburg, Sweden.
UV-vis spectroscopy is a workhorse in analytical chemistry that finds application in life science, organic synthesis, and energy technologies like photocatalysis. In its traditional implementation with cuvettes, it requires sample volumes in the milliliter range. Here, we show how nanofluidic scattering spectroscopy (NSS), which measures visible light scattered from a single nanochannel in a spectrally resolved way, can reduce this sample volume to the attoliter range for solute concentrations in the mM regime, which corresponds to as few as 10 probed molecules.
View Article and Find Full Text PDFOral Delivery of 5-Demethylnobiletin by Media-Milled Black Rice Particle-Stabilized Pickering Emulsion Alleviates Colitis in Mice: Synergistic Effects of Carrier and Loaded Bioactive.
J Agric Food Chem
January 2025
Department of Food Science and Engineering, Jinan University, Guangzhou 510632, China.
Traditional colitis treatment strategies have issues such as side effects and poor lesion targeting. In this study, a milled black rice particle-stabilized Pickering emulsion (BR-5-DMN) has been developed as a delivery vehicle for 5-demethylnobiletin (5-DMN) to treat colitis. The alleviating effects of three 5-DMN delivery systems: BR-5-DMN, Tween 80 emulsion for upper gastrointestinal delivery, and soybean oil with most 5-DMN entering the colon were compared.
View Article and Find Full Text PDFChitosan nano-formulation enhances stability and bactericidal activity of the lytic phage HK6.
BMC Biotechnol
January 2025
Department of Microbiology and Immunology, Faculty of Pharmacy, Beni-Suef University, Beni-Suef, 62511, Egypt.
Background: Successful treatment of pathogenic bacteria like Enterobacter Cloacae with bacteriophage (phage) counteract some hindrance such as phage stability and immunological clearance. Our research is focused on the encapsulation of phage HK6 within chitosan nanoparticles.
Result: Encapsulation significantly improves stability, efficacy, and delivery of phages.
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